HEALTH STATUS AND SOME GENOTYPIC FEATURES OF BA MOTHERS' BORN KIDS



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Abstract

117 BA pregnant women and their kids were followed up and treated within 5 to 10 years. Kids' health status was estimated up to end of follow up. Аllergic pathology level within BA mothers' born kids was significantly higher, than in whole population (52,9% & 25%). Main risk factors of allergic pathology appearance within first 7 years of life are: allergic diseases in both parents (p=0,08), infantile phenotype of BA in kids' mother, (p<0,05), weak genotype of IL-4 (-590 C/T), IL-4R (Q576R), TNF-α (-308G>A) genes. Molecular-genetic study of atopic causal genes could be recommended for allergic risk screening in kids in order to perform further diagnostics and prophylaxis.

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Copyright (c) 2013 Vakharlovskaya M.V., Petrova M.A., Lavrova O.V., Ivaschenko T.E., Fedoseev G.B., Jelenina L.A.

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