CONSTRUCTION AND TESTING OF LIFE VACCINE BASED ON THE PROBIOTIC STRAIN ENTEROCOCCUS FAECIUM L3 AS MEANS FOR PREVENTION OF VAGINAL INFECTION CAUSED BY STREPTOCOCCUS AGALACTIAE

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Abstract


The paper presents the data on construction and evaluation of immunogenic and protective features of the new life vaccine against Streptococcus agalactiae (Group B streptococcus). For the construction of the vaccine a fragment of the Streptococcus agalactiae bac gene have been inserted into the chromosome of the probiotic strain. As a result the probiotic strain eхpressing immunogenic recombinant polypeptide on the cell surface was constructed. Application of the life vaccine in the vaginal cavity of mice induced local and systemic immune response and provided protection against lethal S. agalactiae infection.

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Copyright (c) 2013 Gupalova T.V., Leontieva G.F., Ermolenko E.I., Grabovskaya K.B., Kramskaya T.A., Tsapieva A.N., Koroleva I.V., Suvoro A.N.

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