PEPTIDES OF THYMUS IN THE REGULATION OF STRESS

The aim of this clinical and experimental research is the examination of the role of peptides of thymus in the regulation of stress. At the first stage of research, levels of serum thymic activity (STA) in 112 mother-child pairs have been analyzed in the moment of birth stress. Level of STA of healthy non pregnant women of childbearing age has been taken as the reference rate (n=10). Only healthy parturient women with non-compromised history of physiologically progressing pregnancy had adequate reaction of the organism to the birth stress in the form of the increase of the level of the examined indicator. The next stage of the research was the study of the influence of thymus polypeptide drug tactivin on the behavior, training and ability to resist stress in the experimental animals. The research has been carried out on 510 rats of Wistar line. The drug has been increasing orientative-exploratory behavior of animals and has been exerting mnemotropic effect comparable to the effect of classic nootropic drug piracetam. On the basis of models of memory impairments, it was shown that tactivin improves reproduction of avoidance response in conditions of emotional stress. This effect was comparable to the influence of nootropic drug piracetam and was different from the effect of anxiolytic diazepam. The data received as the result of this research lead to the declaration of stress-limiting activity of polypeptides of thymus.

peptides of thymus, tactivin, emotional stress, behavior, reflex, stressprotective action