REVIEW OF HIV RNA CONCENTRATION OF BLOOD AND CERVICOVAGINAL SPECIMEN AMONG HIV 1A INFECTED WOMEN IN SAINT-PETERSBURG/RUSSIA



Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Original review of HIV RNA in blood/cervicovaginal pair specimen among HIV infected childbearing women in Saint-Petersburg, Russia. Blood, leucocytes and sperm impurity wasn’t criteria for exclusion due to main goal of investigation is to assess correlation between HIV RNA in blood and cervicovaginal specimen as risk factor of HIV sexual transmission. The manuscript provides correlation between leucocytes in cervicovaginal specimen and HIV RNA.

Full Text

Restricted Access

About the authors

A V Samarina

St.-Petersburg Center for Control of AIDS and Infectious Diseases; I.P. Pavlov Medical University

Email: avsamarina@mail.ru

N Ye Dementeva

St.-Petersburg Center for Control of AIDS and Infectious Diseases; Research Institute of Experimental Medicine of the Northwest Branch of the Russian Academy of Medical Sciences

Z N Lisitsyna

St.-Petersburg Center for Control of AIDS and Infectious Diseases; I.P. Pavlov Medical University

A G Rakhmanova

St.-Petersburg Center for Control of AIDS and Infectious Diseases; I.P. Pavlov Medical University

N A Belyakov

St.-Petersburg Center for Control of AIDS and Infectious Diseases; I.P. Pavlov Medical University; Research Institute of Experimental Medicine of the Northwest Branch of the Russian Academy of Medical Sciences

References

  1. Самарина А.В., Дементьева Н.Е., Лисицина З.Н. и др. Содержание РНК ВИЧ в цервиковагинальном секрете у ВИЧ-инфицированных женщин // ВИЧ-инфекция и иммуносупрессии. — 2013. — Т. 5, № 3. — С. 24—34.
  2. Женщина, ребенок и ВИЧ: Руководство для врачей / под ред. Н.А. Белякова, Н.Ю. Рахманиной, А.Г. Рахмановой. — СПб.: Балтийский образовательный центр, 2012. — 600 с.
  3. Вирус иммунодефицита человека — медицина: руководство для врачей / под ред. Н.А. Белякова и А.Г. Рахмановой. — 2-е изд. — СПб.: Балтийский медицинский образовательный центр, 2011. — 656 с.
  4. Беляков Н.А., Виноградова Т. Половой путь передачи ВИЧ в развитии эпидемии // ВИЧ-инфекция и иммуносупрессии. — 2011. — Т. 3, № 4. — С. 7-20.
  5. Anderson B.L., Wang C.C., Delong A.K. et al. Genital tract leukocytes and shedding of genital HIV type 1 RNA // Clin. Infect. Dis.— 2008. — Vol. 47 (9). — P. 1216-1221.
  6. Quinn T.C., Wawer M.J., Sewankambo N. et al. Viral load and heterosexual transmission of human immunodeficiency virus type 1 // N. Engl. J. Med. — 2000. — Vol. 342 (13). — Р. 921-929.
  7. Tovanabutra S., Robison V., Wongtrakul J. et al. Male viral load and heterosexual transmission of HIV-1 subtype E in northern Thailand // J. Acquir. Immune. Defic. Syndr. — 2002. — Vol. 29. — P. 275-283.
  8. Ragni M.V., Faruki H., Kingsley L.A. Heterosexual HIV-1 transmission and viral load in hemophilic patients // J. Acquir. Immune. Defic. Syndr. Hum. Retrovirol. — 1998. — Vol. 17. — P. 42-45.
  9. Lee T.H., Sakahara N., Fiebig E. et al. Correlation of HIV-1 RNA levels in plasma and heterosexual transmission of HIV-1 from infected transfusion recipients // J. Acquir. Immune. Defic. Syndr. Hum. Retrovirol. — 1996. — Vol. 12. — P. 427-428.
  10. Pedraza M.A., del Romero J., Roldan F. et al. Heterosexual transmission of HIV-1 is associated with high plasma viral load levels and a positive viral isolation in an infected partner // J. Acquir. Immune. Defic. Syndr. Hum. Retrovirol. — 1999. — Vol. 21. — P. 120-125.
  11. Osmond D., Bacchetti P., Chaisson R.E. et al. Time of exposure and risk of HIV infection in homosexual partners of men with AIDS // Am. J. Public. Health. — 1988. — Vol. 78. — Р. 944-948.
  12. Hollingsworth T.D., Anderson R.M., Fraser C. HIV-1 transmission, by stage of infection // J. Infect. Dis. — 2008. — Vol. 198. — P. 687-693.
  13. Wawer M.J., Gray R.H., Sewankambo N.K. et al. Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, Uganda // J. Infect. Dis. — 2005. — Vol. 191. — P. 1403-1409.
  14. Gilbert P.B., McKeague I.W., Eisen G. et al. Comparison of HIV-1 and HIV-2 infectivity from a prospective cohort study in Senegal // Stat. Med. — 2003. — Vol. 22. — P. 573-593.
  15. Donnelly C., Leisenring W., Kanki P. et al. Comparison of transmission rates of HIV-1 and HIV-2 in a cohort of prostitutes in Senegal // Bull. Math. Biol. — 1993. — Vol. 55. — P. 731-743.
  16. Kimani J., Kaul R., Nagelkerke N.J. et al. Reduced rates of HIV acquisition during unprotected sex by Kenyan female sex workers predating population declines in HIV prevalence // AIDS. — 2008. — Vol. 22. — P. 131-137.
  17. Boily M.C., Baggaley R.F., Wang L. et al. Heterosexual risk of HIV-1 infection per sexual act: systematic review and meta-analysis of observational studies // Lancet Infect. Dis. — 2009. — Vol. 9 (2). — P. 118-129.
  18. Partners in Prevention HSV/HIV Transmission Study Team: PLoS One. — 2012. — Vol. 7 (11). — Р. e51192.
  19. Centers for Disease Control and Prevention. Sexually Transmitted Diseases Treatment Guidelines 2006 // MMWR. — 2006. — Vol. 55 (№ RR-11).
  20. Workowski K.A., Berman S. Centers for Disease Control and Prevention (CDC). Sexually Transmitted Diseases Treatment Guidelines — 2010 // MMWR Recomm. Rep. — 2010. — Vol. 59 (RR-12). — P. 1-10.
  21. ВИЧ-инфекция и СПИД / Под редакцией В.В. Покровского. — 2-е изд., перераб. и доп. — М.: ГЭОТАР-Медиа, 2010. — 192 с.
  22. Афонина Л.Ю., Воронин Е.Е., Фомин Ю.А. и др. Применение антиретровирусных препаратов в комплексе мер, направленных на профилактику передачи ВИЧ от матери к ребенку // Эпидемиология и инфекционные болезни. Актуальные вопросы. — 2013. — № 1. — С. 1-16.
  23. Unaited Nations, Depatment of Economic and Social Affairs, Population Division (2009), World Contraceptive Use 2009 (POP/DB/CP/Rev 2009).
  24. Сафонова П.В., Рассохин В.В., Виноградова Т.Н. и др. Употребление алкоголя и приверженность к ВААРТ среди ВИЧ-инфицированных женщин // ВИЧ-инфекция и иммуносупрессии. — 2013. — Т. 5, № 2. — С. 42-52.
  25. Самарина А.В., Акатова Н.Ю., Уайтмэн М.К. и др. Факторы, определяющие выбор метода контрацепции у ВИЧ-инфицированных женщин // ВИЧ-инфекция и иммуносупрессии. — 2012. — Т. 4, № 1. — С. 57-68.
  26. Vittinghoff E., Douglas J., Judson F. et al. Per-contact risk of human immunodeficiency virus transmission between male sexual partners // Amer. J. of Epidemiology. — 1999. — Vol. 150. — P. 306-311.
  27. Del Romero J., Marinocovich B., Castilla J. et al. Evaluating the risk of HIV transmission through unprotected orogenital sex // AIDS. — 2002. — Vol. 16, № 9. — Р. 1296-1297.
  28. Townsend C.L., Cortina-Borja M., Peckham C.S. et al. Low rates of mother-to-child transmission of HIV following effective pregnancy interventions in the United Kingdom and Ireland, 2000-2006 // AIDS. — 2008. — Vol. 22, № 8. — P. 973-981.
  29. Baggaley R.F., Boily М.C., White R.G. et al. Risk of HIV-1 transmission for parenteral exposure and blood transfusion // AIDS. — 2006. — Vol. 20, № 6. — P. 805-812.
  30. Heffron R., Donnell D., Rees H. et al. Use of hormonal contraceptives and risk of HIV-1 transmission: a prospective cohort study // Lancet Infect. Dis. — 2012. — Vol. 12, № 1. — P. 19-26.
  31. Laurent C., Seck K., Coumba N. et al. Prevalence of HIV and other sexually transmitted infections, and risk beahviours in unregistered sex workers in Dakar, Senegal // AIDS. — 2003. — Vol. 17. — P. 1811-1816.
  32. Meda N., Ndoye I., M'Boup S. et al. Low and stable HIV infection rates in Senegal: natural course of the epidemic or evidence for success of prevention? // AIDS. — 1999. — Vol. 13. — P. 1397-1405.
  33. Limpakarnjanarat K., Mastro T.D., Yindeeyoungyeon W. et al. STDs in female prostitues in northern Thailand. Proceedings of the IX International Conference on AIDS, Berlin, Gernany; June 6—11, 1993 [abstract P0—C10—2820].
  34. Cohen M.S., Pilcher C.D. Amplified HIV transmission and new approaches to HIV prevention // J. Infect. Dis. — 2005. — Vol. 191. — P. 1391-1393.
  35. Mastro T.D., de Vincenzi I. Probabilities of sexual HIV-1 transmission // AIDS. — 1996. — Vol. 10 (suppl A). — Р. S75—S82.
  36. Gray R.H., Wawer M.J., Brookmeyer R. et al. Probability of HIV-1 transmission per coital act in monogamous, heterosexual, HIV-1-discordant couples in Rakai, Uganda // Lancet. — 2001. — Vol. 357. — P. 1149—1153.
  37. Cameron D.W., Simonsen J.N., DCosta L.J. et al. Female to male transmission of human immunodeficiency virus type 1: risk factors for seroconversion in men // Lancet. — 1989. — Vol. 2. — P. 403—407.
  38. Nopkesorn T., Mastro T.D., Sangkharomya S. et al. HIV-1 infection in young men in Northern Thailand //AIDS. — 1993. — Vol. 7. — P. 1233-1239.
  39. Pilcher C.D., Price M.A., Hoffman I.F. et al. Amplified transmission of HIV-1: comparison of HIV-1 concentrations in semen and blood during acute and chronic infection // AIDS. — 2007. — Vol. 21. — P. 1723—1730.
  40. Baggaley R.F., Boily M.C., White R.G., Alary M. Systematic review of HIV-1 transmission probabilities: In absence of antiretroviral therapy. Geneva: UNAIDS Reference Group on Estimates, Modelling and Projection, 2004.
  41. Holmberg S.D., Horsburgh C.R., Ward J.W. et al. Biologic factors in the sexual transmission of human immunodeficiency virus // J. Infect. Dis. — 1989. — Vol. 160. — P. 116-125.
  42. Van Damme L., Ramjee G., Alary M. et al. Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomised controlled trial // Lancet. — 2002. — Vol. 360. — P. 971—977.
  43. Laga M., Alary M., Nzila N. et al. Condom promotion, sexually transmitted diseases treatment, and declining incidence of HIV-1 infection in female Zairian sex workers // Lancet. — 1994. — Vol. 344. — P. 246—248.
  44. Sewankambo N., Gray R.H., Wawer M.J. et al. HIV-1 infection associated with abnormal vaginal flora morphology and bacterial vaginosis // Lancet. — 1997. — Vol. 350. — P. 546-550.
  45. Cohen M.S., Pilcher C.D. Amplified HIV transmission and new approaches to HIV prevention // J. Infect. Dis. — 2005. — Vol. 191. — P. 1391-1393.
  46. Shiboski S., Padian N.S. Population- and individual-based approaches to the design and analysis of epidemiologic studies of sexually transmitted disease transmission // J. Infect. Dis. — 1996. — Vol. 174 (suppl. 2). — S188—S200.
  47. Boily M.C., Anderson R.M. Measure human immunodeficiency virus transmission and the role of other sexually transmitted diseases. Measures of association and study design // Sex. Transm. Dis. — 1996. — Vol. 23. — P. 312—332.
  48. Kreiss J., Ngugi E., Holmes K. Efficacy of nonoxynol-9 contraceptive sponge use in preventing heterosexual acquisition of HIV in Nairobi prostitutes // JAMA. — 1992. — Vol. 268. — P. 477-482.
  49. Bird K.D. The use of spermicide containing nonoxynol-9 in the prevention of HIV infection // AIDS. — 1991. — Vol. 5. — P. 791—796.
  50. Allen S., Tice J., Van de Perre P. et al. Effect of serotesting with counselling on condom use and seroconversion among HIV discordant couples in Africa // BMJ. — 1992. — Vol. 304. — P. 1605-1609.
  51. Roth D.L., Stewart K.E., Clay O.J. et al. Sexual practices of HIV discordant and concordant couples in Rwanda: effects of a testing and counselling programme for men // Int. J. STD. AIDS. — 2001. — Vol. 12. — P. 181—188.
  52. Hudgens M.G., Longini I.M., Vanichseni S. et al. Subtype-specific transmission probabilities for human immunodeficiency virus type 1 among injecting drug users in Bangkok, Thailand // Am. J. Epidemiol. — 2002. — Vol. 155. — P. 159—168.
  53. Wasserheit J.N. Epidemiological synergy. Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases // Sex. Transm. Dis. — 1992. — Vol. 19. — P. 61—77.
  54. Покровский В.В., Юрин О.Г., Кравченко А.В. Протоколы диспансерного наблюдения и лечения больных ВИЧ-инфекцией // Эпидемиология и инфекционные болезни. Актуальные вопросы. — 2012. — № 6. — С. 1—28.
  55. Baeten J., Kahle E., Lingappa J. et al. Genital HIV-1 RNA predicts risk of heterosexual HIV-1 transmission // Science Translational Medicine. — 2011. — Vol. 3, № 77. — P. 77-88.
  56. Cu-Uvin S., Caliendo A.M., Reinert S. et al. Effect of highly active antiretroviral therapy on cervicovaginal HIV-1 RNA // AIDS. — 2000.— Vol. 14, № 4. — P. 415-21.
  57. Homans J., Christensen S., Stiller T. et al. Permissive and protective factors associated with presence, level, and longitudinal pattern of cervicovaginal HIV shedding // J. Acquir. Immune. Defic. Syndr. — 2012. — Vol. 60 (1). — P. 99-110.
  58. Murnane P.M., Hughes J.P., Celum C. et al. Partners in Prevention HSV/HIV Transmission Study Team. Using plasma viral load to guide antiretroviral therapy initiation to prevent HIV-1 transmission // PLoS One. — 2012. — Vol. 7, № 11.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2013 Samarina A.V., Dementeva N.Y., Lisitsyna Z.N., Rakhmanova A.G., Belyakov N.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 74760 от 29.12.2018 г.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies