Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access


The purpose of the paper was the simultaneous study of the main neurotransmitter of monoaminergic system of the brain, their metabolites, activity of catechol-O-methyltransferase (COMT) and the state of different sybtypes of dopamine (DA) receptors (D 1, D 2L, D 2S, D 4 и D 5) in the developing brain of offspring from mothers alcoholized in gestation and feeding periods. Alcoholization of rats during gestation period decreased activity of all monoaminergic systems studied, that performed with reduction of noradrenaline and DA level in alcoholized fetus as well as of mPNA of COMT, an enzyme of catecholamine metabolism, in the structures of the forebrain on 17 th day but not on 13 th day of prenatal development. In parallel experiments, the increase of the contents of both long and short splice variants of D 2 DA receptor was registered. In postnatal period (4-10-17 days), the further decrease of the DA system activity was observed, in particular, reduction of DOPAC level and DOPAC/DA ratio in rat pups, mothers of which intake alcohol in the gestation period with withdrawal it after birth of offspring. The serotonin system activity was also reduced in alcoholized pups in the postnatal period and was registered in the early stages (on 4th day of life). Therefore, the serotonin system activity is changing on early stages of development in the most degree (4 th day), whereas the inhibition of the DA system activity is registered on the late stages (10 th day of life).

Full Text

Restricted Access

About the authors

E R Bychkov

Anichkov Department of NeuroPharmacology, Institute of Experimental Medicine NWB RAMS

St.-Petersburg, Russia

A A Lebedev

Anichkov Department of NeuroPharmacology, Institute of Experimental Medicine NWB RAMS

St.-Petersburg, Russia

M I Airapetov

Anichkov Department of NeuroPharmacology, Institute of Experimental Medicine NWB RAMS

St.-Petersburg, Russia

R O Roik

Anichkov Department of NeuroPharmacology, Institute of Experimental Medicine NWB RAMS

St.-Petersburg, Russia

P D Shabanov

Anichkov Department of NeuroPharmacology, Institute of Experimental Medicine NWB RAMS

St.-Petersburg, Russia


  1. Шабанов П. Д., Сапронов Н. С. Психонейроэндокринология.- СПб.: Информ-Навигатор, 2010.- 984 с.
  2. Druse M. J., Tajuddin N., Kuo A., Connerty M. Effects of in utero ethanol exposure on the developing dopaminergic systemin rats // J. Neurosci. Res.- 1990.- Vol. 27, № 2.- P. 233-240.
  3. Rathbun W., Druse M. J. Dopamine, serotonin, and acid metabolites in brain regions from the developing offspring of ethanol-treated rats // J. Neurochem.- 1985.- Vol. 44, № 1.- P. 57-62.
  4. Cooper J. D., Rudeen P. K. Alterations in regional catecholamine content and turnover in the male rat brain in response to in utero ethanol exposure // Alcohol Clin. Exp. Res.- 1988.- Vol. 12, № 2.- P. 282-285.
  5. Druse M. J., Kuo A., Tajuddin N. Effects of in utero ethanol exposure on the developing serotonergic system // Alcohol Clin. Exp. Res.-1991.- Vol. 15, № 4.- P. 678-684.
  6. Gillespie R. A., Eriksen J., Hao H. L., Druse M. J. Effects of maternal ethanol consumption and buspirone treatment on dopamine and norepinephrine reuptake sites and D1 receptors in offspring // Alcohol Clin. Exp. Res.- 1997.- Vol. 21, № 3.- P. 452-459.
  7. Barbier E., Houchi H., Warnault V. et al. Effects of prenatal and postnatal maternal ethanol on offspring response to alcohol and psychostimulants in Long Evans rats // Neuroscience.- 2009.- Vol. 161, № 2.- P. 427-440.
  8. Carneiro L. M., Diogenes J. P., Vasconcelos S. M. et al. Behavioral and neurochemical effects on rat offspring after prenatal exposure to ethanol // Neurotoxicol. Teratol.- 2005.- Vol. 27, № 4.- P. 585-592.
  9. Furuya H., Aikawa H., Yoshida T., Okazaki I. Effects of ethyl alcohol administration to THA rat dams during their gestation period on learning behavior and on levels of monoamines and metabolites in the brain of pups after birth // Alcohol Clin. Exp. Res.- 1996.- Vol. 20, № 9, Suppl.- P. 305A-310A.
  10. Clarren S. K., Astley S. J., Bowden D. M. et al. Neuroanatomic and neurochemical abnormalities in nonhuman primate infants exposed to weekly doses of ethanol during gestation // Alcohol Clin. Exp. Res.- 1990.- Vol. 14, № 5.- P. 674-683.
  11. с // Бюл. эксперим. биол. и мед.- 2008.- Т. 146, № 9.- С. 292-296.
  12. Krasnova I. N., Bychkov E. R., Lioudyno V. I. et al. Intracerebroventricular administration of substance P increases dopamine content in the brain of 6-hydroxydopamine-lesioned rats // Neuroscience.- 2000.- Vol. 95, № 1.- P. 113-117.
  13. Шабанов П. Д., Лебедев А. А., Мещеров Ш. К. Дофамин и подкрепляющие системы мозга.- СПб.: Лань, 2002. 208 с.
  14. Шабанов П. Д., Лебедев А. А., Мещеров Ш. К. Последствия внутриамниотического введения 6-гидроксидофамина беременным крысам, оцененные по поведенческим показателям у взрослого потомства // Психофармакол. и биол. наркол.- 2002.- Т. 2, № 1-2.-С. 265-271.
  15. Лебедев А. А., Дробленков А. В., Шабанов П. Д. Структурные изменения в мезокортиколимбической дофаминергической системе мозга при длительной алкоголизации крыс // Бюл. эксперим. биол. и мед.- 2008.- Т. 146, № 12.- С. 698-700.
  16. Шабанов П. Д. Психофармакология.- СПб.: Н-Л, 2008.- 384 с.
  17. Шабанов П. Д., Лебедев А. А. Угнетение самостимуляции латерального гипоталамуса опиатами и опиоидами, вводимыми в центральное ядро миндалины у крыс // Рос. физиол. журн. им. И. М. Сеченова.- 2010.-Т. 97, № 2.- С.180-188.
  18. Guerri C., Baziner A., Riley E. P. Foetal alcohol spectrum disorders and alterations in brain and behavior // Alcohol Alcoholism.- 2009.-Vol. 44, № 2.- P. 108-114.
  19. Riley E. P., McGee C. L. Fetal alcohol spectrum disorders: An overview with emphasis on changes in brain and behavior // Exp. Biol. Med.- 2005.- Vol. 230.- P. 357-365.
  20. Chotro M. G., Arias C. Exposure to low and moderate doses of alcohol on late gestation modifies infantile response to and preference for alcohol in rats // Ann. 1st. Super. Sanita.- 2006.- Vol. 42, № 1.- P. 22-30.
  21. Lee S., Choi I., Kang S., Rivier C. Role of various neurotransmitters in mediating the long-term endocrine consequences of prenatal alcohol exposure // Ann. NY Acad. Sci.- 2008.- Vol. 1144.- P. 176-188.
  22. Шабанов П. Д., Лебедев А. А., Стрельцов В. Ф. Гормональные механизмы подкрепления.- СПб.: Н-Л, 2008.- 208 с.
  23. Koob G. F. Dynamics of neuronal circuits in addiction: reward, antireward, and emotional memory // Pharmacopsychiatry.- 2009.- Vol. 42, Suppl. 1.- P. S32-S41.
  24. Koob G. F. Neurobiological substrates for the dark side of compulsivity in addiction // Neuropharmacology.- 2009.- Vol. 56, Suppl. 1.- P. 18-31.



Abstract: 93

PDF (Russian): 1


Article Metrics

Metrics Loading ...



  • There are currently no refbacks.

Copyright (c) 2012 Bychkov E.R., Lebedev A.A., Airapetov M.I., Roik R.O., Shabanov P.D.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies