Asymmetric dimethylarginine content in plasma of ischemic heart disease patients


Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase. Plasma levels of ADMA are elevated in ischemic heart disease patients and plasma ADMA level was correlated with severity of the disease. Plasma ADMA concentration was higher in man than in woman and elevated with age of patients.

Full Text

Restricted Access

About the authors

V A Lyadoshchuk

Institute of Experimental Medicine NWB RAMS, St. Petersburg

A D Denisenko

Institute of Experimental Medicine NWB RAMS, St. Petersburg


  1. Лядощук В.А., Денисенко АД. Определение концентрации асимметричного диметиларгинина в плазме крови у человека методом высокоэффективной жидкостной хроматографии с электрохимическим детектором // Клин. лаб. диагн. 2010. № 5. С. 5-8.
  2. АНаіп С., Poon L., Chan С. et al. Enzymatic determination of total serum cholesterol // Clin. Chem. 1974. Vol. 20. P. 470-475.
  3. Boger R.H., Bodc-Boger S.M., Sydow K. et al. Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in monkeys with hyperhomocyst(e)inemia or hypercholesterolemia //Arterioscler. Thromb. Vase. Biol. 2000. Vol. 20. P. 1557-1564.
  4. Boger R.H., Ron E.S. L-Arginine improves vascular function by overcoming deleterious effects of ADMA, a novel cardiovascular risk factor // Altem. Med. Rev. 2005. Vol. 10. P. 14-23.
  5. Bucolo G., David H. Quantitative determination of serum triglycerides by the use of enzymes // Clin. Chem. 1973. Vol. 19. P. 476-482.
  6. Cooke J.P. Does ADMA cause endothelial dysfunction? //Arterioscler. Thromb. Vase. Biol. 2000. Vol. 20. P. 2032-2037.
  7. Friedwald W., Levy R., Fredrickson D. Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of preparation ultracentrifuge // Clin. Chem. 1972. Vol. 18. P. 499-509.
  8. Hermenegildo C., Medina P., Peiro M. et al. Plasma concentration of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, is elevated in hyperthyroid patients // J. Clin. Endocrinol. Metab. 2002. Vol. 87 (12). P. 5636-5340.
  9. Jang J.J., Ho H-K.V, Kwan H.H. et al. Angiogenesis is impaired by hypercholesterolemia role of asymmetric dimethylarginine // Circulation. 2000. Vol. 102. P. 1414-1419.
  10. Paiva H., Laakso J., Ruokonen I. et al. Plasma asymmetric dimethylarginine (ADMA), nitrate and the indices of low-density lipoprotein oxidation // Clin. Chim. Acta. 2006. Vol. 371. P. 97-101.
  11. Scalera F., Borlak J., Beckmann B. et al. Endogenous nitric oxide synthesis inhibitor asymmetric dimethyl 1-arginine accelerates endothelial cell senescence // Arterioscler. Thromb. Vase. Biol. 2004. Vol. 24. P. 1816-1822.
  12. Schulze F., Lenzen H., Planefeld C. et al. Asymmetric dimethylarginine is an independent risk factor for coronary heart disease: results from the multicenter coronary artery risk determination investigating the influence of ADMA concentration (CARDIAC) study //Am. Heart J. 2006. Vol. 152. P. 491-^198.
  13. Suda O., Tsutsui M., Morishita T. et al. Asymmetric dimethylarginine produces vascular lesions in endothelial nitric oxide synthase-deficient mice involvement of renin-angio-tensin system and oxidative stress // Arterioscler. Thromb. Vase. Biol. 2004. Vol. 24. P. 1682-1688.
  14. Tcherkas Y.V., Kartsova L.A., Krasnova I.N. Analysis of amino acids in human serum by isocratic reversed- phase high-performance liquid chromatography with electrochemical detection //J. Chromatogr. A. 2001. Vol. 913. P.303-308.
  15. Teerlink T, Nijveldt R.J., Sigrid de Jong., P.A.M. van Leeuwent. Determination of arginine, asymmetric dimethylarginine, and symmetric dimethylarginine in human plasma and other biological samples by high- performance liquid chromatography // Analytical. Biochemistry. 2002. Vol. 303. P. 131-137.
  16. Vallance P., Leiper J. Cardiovascular biology of the asymmetric dimethylarginine: dimethylarginine dimethylaminohydrolase pathway //Arterioscler. Thromb. Vase. Biol. 2004. Vol. 24. P. 1023-1030.
  17. Wang Z., Tang W.H.W., Cho L., Brennan D.M., and Hazen S.L. Targeted metabolomic evaluation of arginine methylation and cardiovascular risks: Potential mechanisms beyond nitric oxide synthase inhibition // Arterioscler. Thromb. Vase. Biol. 2009. Vol. 29. P. 1383-1391.



Abstract - 110


Article Metrics

Metrics Loading ...




  • There are currently no refbacks.

Copyright (c) 2011 Lyadoshchuk V.A., Denisenko A.D.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies