Hormonal markers assessment (leptin, ACTH, cortisol, testosteron) after surgical correction of abdominal obesity

Abstract


The treatment results of 181 patients with abdominal obesity were assessed. 109 patients underwent surgical treatment of abdominal obesity - anterior abdominal lipectomy, 72 were treated conservatively. Surgical group of patients with obesity stage 1-2 showed decrease in leptin, cortisol and testosterone concentration in 1 year after surgery, but surgical patients with obesity stage 3 and conservatively treated patients showed no changes in concentrations of studied hormones. There were no changes of ACTH concentration in both groups. Hormonal status normalization assume body mass stabilization and maintenance.

Full Text

Restricted Access

About the authors

M A Volokh

S. M. Kirov Military Medical Academy, St. Petersburg

Email: marivolokh@mail.ru

Yu Sh Khalimov

S. M. Kirov Military Medical Academy, St. Petersburg


References

  1. Благосклонная Я.В., Красильникова Е.И., Бабенко А.Ю. Ожирение и его потенциальная роль в развитии метаболического синдрома. Лечение // Врач, вед. 1999. № 1 (7). С. 34-36.
  2. Hansen Е., Hajrit, Abumrod N.N. Is all fat the same? The role of fat in the pathogenesis of the metabolic syndrome and type 2 diabetes mellitus // Surgery. 2006. Jun. Vol. 139(6). P.711-716.
  3. I-Ieymsfield S.B., Greenberg A.S., Fujioka K. et al. Recombinant leptin for weight loss in Obese and Lean Adults. A randomized, Controlled, Dose escalation trial //YAMA. 1999. Vol. 282. P. 1568-1575.
  4. Juhasz A., Katone E., Csongradi E., Paragh G. A practicing physician’s view on obesity // Orv. Hetil. 2006. Vol. 147. P. 579-590.
  5. Masuzaki H., Ogawa Y., Isse N., Satoh N.T. et al. Human obese gene expression. Adipocyte-specific expression and regional differences in the adipose tissue // Diabetes. 1995. Vol. 44. P. 855-858.
  6. Muller G. et al. Leptin impairs metabolic actions of insulin in isolated rat adipocytes // J. Biol. Chem. 1997. Vol. 272. № 16. P. 10585-10593.
  7. Lee J.M., Kim S.R., Yoo S.J. et al. The relationship between adipokines, metabolic parameters and insulin resistance in patients with metabolic syndrome and type 2 diabetes // J. Int. Med. Res. 2009. Vol. 37 (6). P. 1803-1812.
  8. Sihna M.K., Ohannesian J.P., Heiman M.L. et al. Nocturnal rise of leptin in lean, obese, and non-insulin-de- pendent diabetes mellitus subjects // J. Clin. Invest. 1997. Vol. 97. P. 1344-1347.
  9. Tartaglia L.A., Demski M., Weng X. et al. Identification and expression cloning of a leptin receptor Ob-R //Cell. 1995. Vol. 83. P. 1263-1271.
  10. Zhao W.G., Zhu H.J. Mechanism, treatment and Evaluation of obesity-induced insulin resistance and type 2 diabetes // Zhongguo. 2010. Vol. 32. P. 7-12.

Statistics

Views

Abstract - 76

Cited-By


Article Metrics

Metrics Loading ...

PlumX

Dimensions

Refbacks

  • There are currently no refbacks.

Copyright (c) 2011 Volokh M.A., Khalimov Y.S.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies