Immunoregulatory properties of the Interferons I type

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Abstract

The type I interferons (IFN) have been the first discovered group of cytokines. However, it keeps extending due to discovery of new members. In the present review new data about the recently revealed members of this family (IFN kappa, lamda and others) are summarized. The characteristics of IFN I type receptors and basic signalling pathways started by the binding molecules of IFN I type with receptors are being considered. The analysis focuses on the mechanisms activated by IFN I type in the immune response to viruses and bacteriae. Connection of IFN I type with others cytokines in various immune reactions, the regulation of the activity of immunocompetent cells by the FN I type, and the role of IFN-a/p in the immune surveillance on tumours have been considered.

About the authors

N. В. Serebryanaya

State Research Institute of Highly Pure Biopreparations

Author for correspondence.
Email: shabanov@mail.rcom.ru
Russian Federation, Saint Petersburg

S. A. Ketlinsky

State Research Institute of Highly Pure Biopreparations

Email: shabanov@mail.rcom.ru
Russian Federation, Saint Petersburg

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