Biological and clinical-morphological aspects of the study of malignant tumor metastasis

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Metastasizing is one of the major stages in malignant tumor pathogenesis when considering it from clinical and, especially, prognostic point of view. On this reason it is being subjected to detailed investigation. The research information here became hurricane-like over the last 5-6 years. It includes an enormous amount of data obtained in clinical and experimental oncology, tumor pathology, cytogenetics and biochemistry of neoplasm. This article, which is represented as an overview of a literature, summarizes and discusses the updated results achieved in the mentioned parts of oncology, as well as the results of personal research.

About the authors

N. M. Anichkov

Mechnikov State Medical Academy

Author for correspondence.
Email: shabanov@mail.rcom.ru

Член-корреспондент РАМН

Russian Federation, St. Petersburg, 195067

References

  1. Аничков Н.М. К учению о метастазировании злокачественных опухолей // Сб. науч. тр. «Патоморфология в Санкт-Петербурге» / Ред. Н. М. Аничков. Российское отд. Междунар. акад. патологии. СПб., 1993. С. 16-25.
  2. Аничков Н.М., Борисов А. В., Габуния У. А. Лимфатические пути и метастазирование рака. Тбилиси: Мецниереба, 1989. 128 с.
  3. Aparicio Т., Kermorgant S., Dessirier V. et al. Matrix metalloproteinase inhibition prevents colon cancer peritoneal carcinomatosis development and prolongs survival in rats // Carcinogenesis. 1999. Vol. 20. P. 1445-1451.
  4. Baker A.H., George S.J., Zaltsman A.B. et al. Inhibition of invasion and induction of apoptotic cell death of cancer cell lines by overexpression of TIMP-3 // Br. J. Cancer. 1999. Vol. 79. P. 1347-1355.
  5. Barinaga M. Designing therapies that target tumor blood vessels [news; comment] // Science. 1997. Vol. 275. P. 482-484.
  6. Bauer K.S., Figg W.D., Hamilton J.M. et al. A pharmacokinetically guided phase II study of carboxyamidotriazole in androgen-independent prostate cancer // Clin. Cancer Res. 1999. Vol. 5. P. 2324-2329.
  7. Berx G., Cleton Jansen A. M., Strumane K. et al. E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain // Oncogene. 1996. Vol. 13. P. 1919-1925.
  8. Bigg H.F, Shi Y.E., Liu Y.E. et al. Specific, high affinity binding of tissue inhibitor of metallopro- teinases-4 (TIMP-4) to the COOH-terminal hemopexin-like domain of human gelatinase A. TIMP-4 binds progelatinase A and the COOH- terminal domain in a similar manner to TIMP-2 // J. Biol. Chem. 1997. Vol. 272. P. 15496-15500.
  9. Brown J. D., Moon R. T. Wnt signaling: why is everything so negative? // Curr. Opin. Cell Biol. 1998. Vol. 10. P. 182-187.
  10. Butler G.S., Apte S.S., Willenbrock F., Murphy G. Human tissue inhibitor of metalloproteinases 3 interacts with both the N- and C-termi-nal domains of gelatinases A and B. Regulation by polyanions // J. Biol. Chem. 1999. Vol. 274. P. 19846-10851.
  11. Chambers A. F., Matrisian L. M. Changing views of the role of matrix metalloproteinases in metastases // J. Natl. Cancer Inst. 1997. Vol. 89. P. 1260-1270.
  12. Chen H., Paradies N.E., Fedor C.M., Bracken- bury R. E-cadherin mediates adhesion and suppresses cell motility via distinct mechanisms // J.Cell Sci. 1997. Vol. 110. P. 345-356.
  13. Dezube B.J., Von Roenn J. H., Holden IV. J. et al. Fumagillin analog in the treatment of Kaposi's sarcoma: a phase I AIDS Clinical Trial Group study // J. Clin. Oncol. 1998. Vol. 16. P. 1444-1449.
  14. Eckhardt S. G., Pluda J. M. Development of angiogenesis inhibitors for cancer therapy // Invest. New Drugs. 1997. Vol. 15. P. 1-3.
  15. Engers R., Gerharz C.D., Donner A. et al. In vitro invasiveness of human epithelioid-sarcoma cell lines: association with cell motility and inverse correlation with the expression of tissue inhibitor of metalloproteinases // Int. J. Cancer. 1999. Vol. 80. P. 406-412.
  16. Engers R., Gabbert H. E. Mechanisms of tumor metastasis: cell biological aspects and clinical implications // J. Cancer Res. Clin. Oncol. 2000. Vol. 126. P. 682-692.
  17. Evans T. R., Kaye S. B. Retinoids: present role and future potential // Br. J. Cancer. 1999. Vol. 80. P. 1-8.
  18. Folkman J. Angiogenesis and angiogenesis inhibition: an overview // EXS. 1997. Vol. 79. P. 1-8.
  19. Giancotti F. G., Ruoslahti E. Integrin signaling // Science. 1999. Vol. 285. P. 1028-1032.
  20. Gomez D. E., Alonso D. E, Yoshiji H, Thor-geirs- son U. P. Tissue inhibitors of metalloproteinases: structure, regulation and biological functions // Eur. J. Cell Biol. 1997. Vol. 74. P. 111-122.
  21. Harris A. L. Anti-angiogenesis therapy and strategies for intergrating it with adjuvant therapy // Recent Results Cancer Res. 1998. Vol. 152. P. 341-352.
  22. Hart I.R. Perspective: tumor spread - the problems of latency // J. Pathol. 1999. Vol. 187. P. 91-94.
  23. Hejna M., Raderer M., Zielinski С. C. Inhibition of metastases by anticoagulants // J. Natl. Cancer Inst. 1999. Vol. 91. P. 22-36.
  24. Hӧfler H. Diffuse-type gastric cancer: from H&E-diagnosis and molecular pathology to specific therapy // Verh. Dtsch. Ges. Path. 1999. Bd. 83. S. 148-254.
  25. Hordijk P.L., ten Klooster J.P., van der Kammen R. A. et al. Inhibition of invasion of epithelial cells by Tiaml-Rac signaling // Science. 1997. Vol. 278. P. 1464-1466.
  26. Jiang W. G. Cell adhesion molecules in the formation of liver metastasis // J. Hepatobiliary Pancreat. Surg. 1998 (a). Vol. 5. P. 375-382.
  27. Jiang W. G. Regulation of cell adhesion: a central mechanism in the anticancer action of essential fatty acids (review) // Int. J. Mol. Med. 1998 (b). Vol. 1. P. 621-625.
  28. Jiang W.G., Bryce R.P, Horrobin D.F, Mansei R. E. Regulation of tight junction permeability and occludin expression by polyunsaturated fatty acids // Biochem. Biophys. Res. Commun. 1998. Vol. 244. P. 414-420.
  29. Keely P.J., Westwick J. K, Whitehead I.P. et al. Cdc42 and Rac 1 induce integrin-mediated cell motility and invasiveness through PI(3)K // Nature. 1997. Vol. 3 90. P. 63 2-63 6.
  30. Kim L. T., Yamada К M. The regulation of expression of integrin receptors // Proc. Soc. Exp. Biol. 1997. Vol. 214. P. 123-131.
  31. Kuroda S., Fukata M., Nakagawa M., Fujii K. et al. Role of IQGAP1, a target of the small GTPases Cdc42 and Rac 1, in regulation of E-cad- herin-mediated cell-cell adhesion // Science. 1998. Vol. 281. P. 832-835.
  32. Kuroda S., Fukata M., Nakagawa M., Kaibuchi K. Cdc42, Rac 1 and their effector IQGAP1 as molecular switches for cadherin-mediated cellcell adhesion // Biochem. Biophys. Res. Commun. 1999. Vol. 262. P. 1-6.
  33. Leger O.J., Yednock T.A., Tanner L. et al. Humanization of a mouse antibody against human alpha-4 integrin: a potential therapeutic for the treatment of multiple sclerosis // Hum. Antibodies. 1997. Vol. 8. P. 3-16.
  34. Lin К. C., Castro A. C. Very late antigen 4 (VLA4) antagonists as anti-inflammatory agents // Curr. Opin. Chem. Biol. 1998. Vol. 2. P. 453-457.
  35. Lode H.N, Moehler T., Xiang R. et al. Synergy between an antiangiogenic integrin alpha-v antagonist and an antibody-cytikine fusion protein eradicates spontaneous tumor metastases // Proc. Natl. Acad. Sci. USA. 1999. Vol. 96. P. 1591-1596.
  36. Macaulay V.M., O'Byrne K. J., Saunders M. P. et al. Phase I study of intrapleural batimastat (BB-94), a matrix metalloproteinase inhibitor, in the treatment of malignant pleural effusions // Clin. Cancer Res. 1999. Vol. 5. P. 513-520.
  37. Mainiero F., Murgia C., Wary К. K. et al. The coupling of alpha6beta4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation // EMBO J. 1997. Vol. 16. P. 2365-2375.
  38. Marches R., Scheuermann R. H., Uhr J. W. Cancer dormancy: role of cycline-dependent kinase inhibitors in induction of cell cycle arrest mediated via membrane IgM // Cancer Res. 1998. Vol. 58. P. 691-697.
  39. Mareel M., Boterberg T., Noe V. et al. E-cadherin/catenin/cytoskeleton complex: a regulator of cancer invasion // J. Cell Physiol. 1997. Vol. 173. P. 271-274.
  40. Meiners S., Brinkmann V., Naundorf H., Birchmeier W. Role of morphogenetic factors in metastasis of mammary carcinoma cells // Oncogene. 1998. Vol. 16. P. 9-20.
  41. Meyer T., Hart I. R. Mechanisms of tumour metastasis // Eur. J. Cancer. 1998. Vol. 34. P. 214-221.
  42. Mohanam S., Chintala S.K., Go Y. et al. In vitro inhibition of human glioblastoma cell line invasiveness by antisense uPA receptor // Oncogene. 1997. Vol. 14. P. 1351-1359.
  43. Nakanishi Y., Ochiai A., Akimoto S. et al. Expression of E-cadherin, alpha-catenin, beta-catenin and plakoglobin in esophageal carcinomas and its prognostic significance: immunohistochemical analysis of 96 lesions // Oncology. 1997. Vol. 54. P. 158-165.
  44. Nobes C. D., Hall A. Rho GTPases control polarity, protrusion, and adhesion during cell movement // J. Cell Biol. 1999. Vol. 144. P. 1235-1244.
  45. Palacios J., Gamallo C. Mutations in the beta- catenin gene (CTNNB1) in endometrioid ovarian carcinomas // Cancer Res. 1998. Vol. 58. P. 1344-1347.
  46. Palecek S.P, Loftus J. C., Ginsberg M. H. et al. Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness // Nature. 1997. Vol. 385. P. 537-540.
  47. Perl A. K., Wilgenbus P., Dahl U., Semb E., Christofori G. A causal role for E-cadherin in the transition from adenoma to carcinoma // Nature. 1998. Vol. 392. P. 190-193.
  48. Rabbani S. A., Xing R. H. Role of urokinase (uPA) and its receptor (uPAR) in invasion and metastasis of hormone-dependent malignancies // Int. J. Oncol. 1998. Vol. 12. P. 911-920.
  49. Reuning U., Magdolen V., Wilhelm O. et al. Multifunctional potential of the plasminogen activation system in tumor invasion and metastasis (review) // Int. J. Oncol. 1998. Vol. 13. P. 893-906.
  50. Ruoslahti E. Integrins as signaling molecules and targets for tumor therapy // Kidney Int. 1997. Vol. 51. P. 1413-1417.
  51. Sabichi A. L., Lerner S., Grossman H. B., Lippman S. M. Retinoids in the chemoprevention of bladder cancer // Curr. Opin. Oncol. 1998. Vol. 10. P. 479-484.
  52. SanderE. E., van Delft S., ten Kloos ter J. P. et al. Matrix-dependent Tiaml/Rac signaling in epithelial cells promoters either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase // J. Cell Biol. 1998. Vol. 143. P. 1385-1398.
  53. Shaw L. M., Rabinovitz I., Wang H. H. et al. Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion // Cell. 1997. Vol. 91. P. 949-960.
  54. Sheetz M. P., Felsenfeld D., Galbraith C. G., Choquet D. Cell migration as a five-step cycle // Biochem. Soc. Symp. 1999. Vol. 65. P. 223-243.
  55. Torzewski M., Sarbia M., Verreet P. et al. Prognostic significance of urokinase-type plasminogen activator expression in squamous cell carcinomas of the esophagus // Clin Cancer Res. 1997. Vol. 3. P. 2263-2268.
  56. Vassilev T. L., Kazatchkine M. D., Van Huyen J. P. et al. Inhibition of cell adhesion by antibodies to Arg-Gly-Asp (RGD) in normal immunoglobulin for therapeutic use (intravenous immunoglobulin, IVIg) // Blood. 1999. Vol. 93. P. 3624-3 631.
  57. Vitetta E. S., Tucker T. F., Racila E. et al. Tumor dormancy and cell signaling. V. Regrowth of the BCL1 tumor after dormancy is established // Blood. 1997. Vol. 89. P. 4425-4436.
  58. Wang M., Liu Y. E., Greene J. et al. Inhibition of tumor growth and metastasis of human breast cancer cells transfected with tissue inhibitor of metalloproteinase 4 // Oncogene. 1997. Vol. 14. P. 2767-2774.
  59. Wylie S., MacDonald I. C., Varghese H. J. et al. The matrix metalloproteinase inhibitor batimastat inhibits angiogenesis in liver metastases of B16F1 melanoma cells // Clin. Exp. Metastasis. 1999. Vol. 17. P. 111-117.
  60. Yap A. S., Brieher W. M., Gumbiner В. M. Molecular and functional analysis of cadherinbased adherens junctions // Annu. Rev. Cell Dev. Biol. 1997. Vol. 13. P. 119-146.
  61. Yoshioka T., Masuko T., Kotanagi H. et al. Homotypic adhesion through carcinoembryonic antigen plays a role in hepatic metastasis development // Jpn. J. Cancer Res. 1998. Vol. 89. P. 177-185.
  62. Yoshioka K, Nakamori S., Itoh K. Overexpression of small GTP-binding protein RhoA promotes invasion of tumor cells // Cancer Res. 1999. Vol. 59. P 2004-2010.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2003 Eco-Vector


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 74760 от 29.12.2018 г.