The role of lipid peroxidation in mechanisms of posttraumatic cerebrasthenias in the experiment

In rats, both the lipid peroxidation processes and the activity of antioxidant systems in the brain of high (HR) and low resistance (LR) to hypoxia animals with asthenic features due to brain injury have been studied. The brain injury was modeled by falling load weighting 64 g on the head of animal fixed in special apparatus. The decreased motor and explorative behavior, and elevated anxiety were registered in both HR and LR to hypoxia rats within 14 days after brain injury. The lipid peroxidation processes (the level of lipid hydroperoxides, dienic and trienic conjugates, malonic dialdehyde) increased by 40-70% in HR and especially in LR rats. Concurrently, the activity of antioxidant systems (activity of superoxiddismutase, catalase and level of redox glutation) was declined, in more degree in LR than in HR rats. It is concluded that individual resistance to hypoxic factor determines the formation of posttraumatic cerebrasthenia in significant degree.