Metabolic syndrome of insulin resistance and its consequences in endometrial cancer

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Abstract

The signs of insulin resistance syndrome and its association with some features of the disease and DNA damage in somatic and tumor tissue were evaluated in 99 endometrial cancer patients. The frequency of insulin resistance syndrome counted on the basis of fasting plasma glucose and insulin concentrations is equal to 0,35 (95% confidence limits of 0,24 - 0,46) in endometrial cancer patients who do not have a history of diabetes mellitus Patients with well or moderately differentiated endometrial adenocarcinomas have statistically significantly higher basal and stimulated plasma insulin and C-peptide concentrations than did patients with poorly differentiated endometrial adenocarcinomas or rarely encountered tumors of endometrium. At the same time the level of fasting insulinemia positively correlates with disease stage, local and regional tumor spreading in the group of patients with wel or moderately differentiated endometrial adenocarcinomas. On the other side, hyperinsulinemia and other hormonal-metabolic disturbances typical for insulin resistance syndrome do not increase the probability of DNA damage of somatic cells (according to the data of micronucleus test). No association between hormonal-metabolic disturbances and the degree of DNA unwinding in tumor and visually unchanged endometrium has been found too; that is insulin resistance/ hyperinsulinemia (as distinct to hyperestrogenemia) does not result in increasing genotoxical damages in tumor and normal tissue of endometrium. The data obtained confirm once more the necessity of treatment strategies directly aimed at correcting hormonal-metabolic disturbances in endometrial cancer patients.

About the authors

L. M. Berstein

N.N.Petrov Research Institute of Oncology

Author for correspondence.
Email: medaj@eco-vector.com
Russian Federation, St. Petersburg, 197758

Ju. O. Kvatchevskaja

N.N.Petrov Research Institute of Oncology

Email: medaj@eco-vector.com

Medical Academy of Postgraduate Studies

Russian Federation, St. Petersburg, 193015

V. B. Gamajunova

N.N.Petrov Research Institute of Oncology

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg, 193015

T. E. Poroshina

N.N.Petrov Research Institute of Oncology

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg, 197758

A. F. Ourmantcheeva

N.N.Petrov Research Institute of Oncology

Email: medaj@eco-vector.com

Medical Academy of Postgraduate Studies

Russian Federation, St. Petersburg, 193015

I. G. Kovalenko

N.N.Petrov Research Institute of Oncology

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg, 193015

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