Analysis of the interaction of genetic thrombophilic determinants with smoking in young men after myocardial infarction

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Abstract

It have been analyzed the distribution genetic risk factors determining thrombophilic conditions-FV Leiden, 20210G/A of the prothrombin gene, polymorphism in the promoter of the в-fibrinogen gene, polymorphism PIA1/A2 GP IIIa, mutation C677T in the MTHFR gene, 4G/5G polymorphism of the PAI-1 gene and insertion-deletion in the promoter of the clotting factor VII gene among smoking and non-smoking men with myocardial infarction (MI) before the age of 45 years old. The strong interaction between smoking and investigated mutations was revealed. This interaction raised the risk of development of MI more strongly then action environmental and genetic factors taken separately. The greatest cooperative effect was observed at the combination of smoking with F V Leiden or with PIA2 GP IIIa. The relative risk (RR) of development of MI increased up 10.5 time. It should be noted that smoking alone increased RR in 5.5 time, PIA2 GP IIIa - in 2 time, and F V Leiden didn't bring of any impact to the risk of development of MI in young men.

About the authors

O. V. Sirotkina

St. Petersburg Konstantinov Institute of Nuclear Physics RAS

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

A. M. Sheidina

St. Petersburg Konstantinov Institute of Nuclear Physics RAS

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

M. V. Volkova

St. Petersburg Konstantinov Institute of Nuclear Physics RAS

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

O. A. Berkovich

I. P. Pavlov State Medical University

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

E. A. Bazhenova

I. P. Pavlov State Medical University

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

D. V. Cherkashin

Military Medical Academy

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

S. A. Boitsov

Military Medical Academy

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

E. V. Shlachto

I. P. Pavlov State Medical University

Email: shabanov@mail.rcom.ru

член-корреспондент 

Russian Federation, St. Petersburg

I. E. Schwarz

St. Petersburg Konstantinov Institute of Nuclear Physics RAS; I. P. Pavlov State Medical University

Author for correspondence.
Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg

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