The molecular-genetic research of gap junction intercellular communications in colorectal cancer

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Abstract

This article presents the comparative analysis of perspectives in the field of molecular-genetic research of gap junction intercellular communications (GJIC) in colorectal cancer and other malignant tumors. The current investigations are characterized by profound theoretical studies and experimental research of GJIC antitumor properties. Special interest is rewarding to in vitro and in vivo experiments showed that different cancer cells transfected with GJIC-connexin genes reduced their tumorigenicity significantly. Some somatic connexin gene mutations were recently been revealed at the late stage of sporadic human colorectal cancer. This fact let us suggest that more detail molecular-genetic investigations of connexin genes in malignant tumors further could be a perspective line of cancer research. The results of the investigations could be demanded for the development of early diagnosis and gene therapy of malignant diseases.

About the authors

N. A. Iatckii

I. I. Pavlov State Medical University

Author for correspondence.
Email: shabanov@mail.rcom.ru

член-корреспондент РАМН

Russian Federation, St. Petersburg, 197022

S. V. Vasil'ev

I. I. Pavlov State Medical University

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg, 197022

D. E. Popov

I. I. Pavlov State Medical University

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg, 197022

M. V. Dubina

I. I. Pavlov State Medical University

Email: shabanov@mail.rcom.ru
Russian Federation, St. Petersburg, 197022

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