Cognitive state of epileptic patients

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Abstract

Epilepsy is а chronic disease, characterized among other symptoms also by the cognitive disorders. Known factors, influencing cognitive condition of the patient, are etiology, type of seizures and therapy. Valuation of cognitive state of patient is very important part of routine neurological investigation. We studied 22 patients diagnosed with epilepsy (14 women and 8 men), age from 18 to 59 years. Focal symptomatic epilepsy was diagnosed in 14 cases, cryptogenic epilepsy in 7 cases and 1 case was idiopathic generalized epilepsy. We used Mini-Mental State Examination and Frontal Assessment Battery tests to evaluate state of cognitive disorders in these patients. ln 40% of cases both tests results showed cognitive disorders on а level of mild cognitive dysfunction, or mild dementia. Mostly these disorders affected patients with а long history of disease (more than 18years long), which began in early childhood; absence of clinical effect of АЕР therapy also seemed to affect cognitive state. We conclude that even on early stage of АЕР therapy neurologist must consider the possibility to use medications with по negative effect on cognitive state. Also we recommend wider usage of tests on cognitive state (MMSE, FAB) in clinical diagnostic of epilepsy. Both methods are proved effective and reliable, and simple to use.

About the authors

E. V. Borisova

Research lnstitute of Experimental Medicine of the RAMS; The City epileptology centre, St. Petersburg

Author for correspondence.
Email: medaj@eco-vector.com
Russian Federation, St. Petersburg; St. Petersburg

N. G. Eliseeva

Research lnstitute of Experimental Medicine of the RAMS; The City epileptology centre, St. Petersburg

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg; St. Petersburg

V. B. Voitenkov

Research lnstitute of Experimental Medicine of the RAMS; The City epileptology centre, St. Petersburg

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg; St. Petersburg

S. A. Sviridova

Research lnstitute of Experimental Medicine of the RAMS; The City epileptology centre, St. Petersburg

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg; St. Petersburg

L. K. Tazitdinova

Research lnstitute of Experimental Medicine of the RAMS; The City epileptology centre, St. Petersburg

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg; St. Petersburg

D. V. Elisarova

Research lnstitute of Experimental Medicine of the RAMS; The City epileptology centre, St. Petersburg

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg; St. Petersburg

I. V. Larina

Research lnstitute of Experimental Medicine of the RAMS; The City epileptology centre, St. Petersburg

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg; St. Petersburg

М. J. Кissin

Research lnstitute of Experimental Medicine of the RAMS; The City epileptology centre, St. Petersburg

Email: medaj@eco-vector.com
Russian Federation, St. Petersburg; St. Petersburg

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Copyright (c) 2008 Borisova E.V., Eliseeva N.G., Voitenkov V.B., Sviridova S.A., Tazitdinova L.K., Elisarova D.V., Larina I.V., Кissin М.J.



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