About the risk of BA formation in early kids, born by BA females

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Abstract

Study of different factors, influencing the appearance of the conditions, predisposing to BA, and BA onset in kids, born by BA pregnants. 194 kids, born by females with allergic BA, were studied. Mothers were performed complex clinico-functional examination. In mothers GSTT1 and GSTM1 genes were studied with PCR method. Clinical follow-up, dynamic ultrasound examination Doppler measurements of fetoplacental complex and haemostasis investigation were carried out by obstetrician. Primary prophylaxis of allergic pathology in kids was performed at every stage. Kids were followed-up by pediatrician-allergologist. Special clinical genetic study was performed as well as analysis of specific IgE. The proving data about significance of different internal and environmental factors in atopic diseases formation in kids, born by BA females were acquired. Diet violations while pregnancy and breast feeding, short term of pure breast feeding and cow's milk protein intolerance are concerned to be to be the most important factors. Also the role of pregnancy complication was shown. Affiliation of the kid to GSTM1 0/0 and GSTT1 0/0 genotypes seems to be a significant factor. Positive influence of adequate BA control during pregnancy to allergic pathology development in kids was demonstrated.

About the authors

О. V. Lavrova

I. P. Pavlov State Medical University; Ott Institute of Obstetrics and Gynecology of the Russian Academy of Medical Sciences

Author for correspondence.
Email: shabanov@mail.rcom.ru

Research Institute of pulmonology

Russian Federation, St. Petersburg; St. Petersburg

М. A. Petrova

I. P. Pavlov State Medical University; Ott Institute of Obstetrics and Gynecology of the Russian Academy of Medical Sciences

Email: shabanov@mail.rcom.ru

Research Institute of pulmonology

Russian Federation, St. Petersburg; St. Petersburg

G. B. Fedoseev

I. P. Pavlov State Medical University; Ott Institute of Obstetrics and Gynecology of the Russian Academy of Medical Sciences

Email: shabanov@mail.rcom.ru

Research Institute of pulmonology

Russian Federation, St. Petersburg; St. Petersburg

Т. Е. Ivaschenko

I. P. Pavlov State Medical University; Ott Institute of Obstetrics and Gynecology of the Russian Academy of Medical Sciences

Email: shabanov@mail.rcom.ru

Research Institute of pulmonology

Russian Federation, St. Petersburg; St. Petersburg

Е. A. Shapovalova

I. P. Pavlov State Medical University; Ott Institute of Obstetrics and Gynecology of the Russian Academy of Medical Sciences

Email: shabanov@mail.rcom.ru

Research Institute of pulmonology

Russian Federation, St. Petersburg; St. Petersburg

N. A. Kelembet

I. P. Pavlov State Medical University; Ott Institute of Obstetrics and Gynecology of the Russian Academy of Medical Sciences

Email: shabanov@mail.rcom.ru

Research Institute of pulmonology

Russian Federation, St. Petersburg; St. Petersburg

A. G. Chermensky

I. P. Pavlov State Medical University; Ott Institute of Obstetrics and Gynecology of the Russian Academy of Medical Sciences

Email: shabanov@mail.rcom.ru

Research Institute of pulmonology

Russian Federation, St. Petersburg; St. Petersburg

М. N. Zaxarova

I. P. Pavlov State Medical University; Ott Institute of Obstetrics and Gynecology of the Russian Academy of Medical Sciences

Email: shabanov@mail.rcom.ru

Research Institute of pulmonology

Russian Federation, St. Petersburg; St. Petersburg

М. V. Vaxarlovskaja

I. P. Pavlov State Medical University; Ott Institute of Obstetrics and Gynecology of the Russian Academy of Medical Sciences

Email: shabanov@mail.rcom.ru

Research Institute of pulmonology

Russian Federation, St. Petersburg; St. Petersburg

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