Роль субпопуляции естественных регуляторных CD4 +CD25 + Т-клеток в норме и при патологии



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Естественные регуляторные CD4 +CD25 +Т-лимфоциты (Т ед-клетки) играют ключевую роль в поддержании нормального иммунного гомеостаза. Treg-клетки ингибируют активность эффекторныхТ-лимфоцитов, участвуя в предотвращении развития аутоиммунных процессов, тогда как подавление их активности может приводить к возникновению тяжелых или фатальных аутоиммунных и лимфопролиферативных заболеваний. Показана роль CD4 +CD25 +T reg-KaeTOK в супрессии реакции трансплантат против хозяина, предотвращении развития аллергических реакций, а также подавлении иммунного ответа при поражении организма патогенами. В организме пациентов со злокачественными новообразованиями Т гед-клетки подавляют противоопухолевый иммунный ответ.

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Ольга Викторовна Акинфиева

ФГУ «Российский научно-исследовательский институт гематологии и трансфузиологии»

Email: olgaakinf@yandex.ru

Л Н Бубнова

ФГУ «Российский научно-исследовательский институт гематологии и трансфузиологии»

Список литературы

  1. Быковская С.Н., Насонов Е.Л. Роль дефектов иммуносупрессии в развитии аутоиммунных заболеваний // Науч. практ. ревматол. 2005. № 4. С. 81-84.
  2. Воробьев А.А., Быковская С.Н., Пашков Е.П. и др. Роль клеток-регуляторов CD25+CD4+ в развитии хронических инфекционных заболеваний // Вести. РАМН. 2006. № 9-10. С. 24-29.
  3. Свиридова В.С., Кологривова Е.Н., Пронина Н.А. и др. Т-лимфоциты - ключевые иммунорегуляторные клетки // Бюл. сиб. мед. 2007. № 1. С. 83-88.
  4. Asano М., Toda М., Sakaguchi N. et al. Autoimmune disease as a consequence of developmental abnormality of a cell subpopulation // J. Exp. Med. 1996. Vol. 184. P. 387-396.
  5. Baecher-Allan C., Viglieta V, Hafler D.A. Human CD4+CD25+ regulatory T cells // Semin. Immunol. 2004. Vol. 16. P. 89-98.
  6. Belkaid Y., Piccirillo C.A., Mendez S., Shevach E.M., Sacks D.L. CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity // Nature. 2002. Vol. 420. P. 502-507.
  7. Bemrett C.L., Brunlcow M.E., Ramsdell E A rare polyadenylation signal mutation of the FOXP3 gene (AAU- AAA-AAUGAA) leads to the IPEX syndrome // Im- munogenetics. 2001. Vol. 53. P. 435^139.
  8. Berger C.L., Tigelaar R., Cohen J. Cutaneous T-cell lymphoma: malignant proliferation of T-regulatory cells//Blood. 2005. Vol. 105. P. 1640-1647.
  9. Beyer C.L., Kochanek M., Darabi K. Reduced frequences and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine // Blood. 2005. Vol. 106. P. 2018-2025.
  10. BoettlerT., Spangenberg H.C., Neumann-HaefelinC. T cells with a CD4+CD25+ regulatory phenotype suppress in vitro proliferation of virus-specific CD8+ T cells during chronic hepatitis C virus infection // J. Virol. 2005. Vol. 79. P. 7860-7867.
  11. Bopp T. Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression // J. Exp. Med. 2007. Vol. 204. P. 1303-1310.
  12. Borsellino G. Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression // Blood. 2007. Vol. 110. P. 1225- 1232.
  13. Cao X. Granzyme В and perforin are important for regulatory T cell-mediated suppression of tumor clearance // Immunity. 2007. Vol. 27. P. 635-646.
  14. Caramalho I., Lopex-Carvalho T., Ostler D. Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide // J. Exp. Med. 2003. Vol. 197. P. 403^111.
  15. Chai J.G., Xue S.A., Coe D., Addey C., Bartok I., ScottD. Regulatory T cells by in vitro Foxp3 gene transfer, can induce transplantation tolerance // Transplantation. 2005. Vol. 79. R 1310-1316.
  16. Chatila T.A. Role of regulatory T cells in human diseases // J. Allergy. Clin. Immunol. 2005. Vol. 116. P. 949-959.
  17. Cohen J.L., Trenado A., Vasey D. et al. CD4(+)CD25(+) immunoregulatory T cells: new therapeutics for graft-versus-host disease // J. Exp. Med. 2002. Vol. 196. P. 401-406.
  18. Cupedo T., Nagasawa M., Weijer K. Development and activation of regulatory T cells in the human fetus // Eur. J. Immunol. 2005. Vol. 35. P. 389-390.
  19. Curiel T.J., Coukos G., Zou L. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced'survival // Nat. Med. 2004. Vol. 10. P. 942-949.
  20. Deaglio S. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression // J. Exp. Med. 2007. Vol. 204. P. 1257-1265.
  21. Dieckmann D., Plottner H., Dotterweich S. et al. Activated CD4+CD25+ T cells suppress antigen-specific CD4+ and CD8+ T cells but induce a suppressive phenotype only in CD4+ T cells // Immunology. 2005. Vol. 115. P. 305-314.
  22. Earle K.E., Tang Q., Zhou X. In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation // Clin. Immunol. 2005. Vol. 115. P. 3-9.
  23. Edinger M., Hoffmann P., Ermann J. CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation // Nat. Med. 2003. Vol. 9. P. 1144-1150.
  24. Eggena M.P., Barugahare B., Jones N. Depletion of regulatory T cells in HIV infection is associated with immune activation // J. Immunol. 2005. Vol. 174. P. 4407-4414.
  25. Elpek K.G., Lacelle Ch., Singh N.P. et al. CD4+CD25+ T regulatory cells dominate multiple immune evasion mechanisms in early but not late phases of tumor development in a В cell lymphoma model // J. Immunol. 2007. Vol. 178. P. 6840-6848.
  26. Fallarino F. Modulation of tryptophan catabolism by regulatory T cells // Nat. Immunol. 2003. Vol. 4. P. 1206-1212.
  27. Fehervari Zoltan and Shimon Salcaguchi. CD4+Tregs and immune control // J. Clin. Invest. 2004. Vol. 114. № 9. P. 1209-1217.
  28. Fehervari Zoltan and Shimon Sakaguchi. Control of Foxp3+ CD25+CD4+ regulatory cell activation and function by dendritic cells // Intern. Immunol. 2004. Vol. 16(12). P. 1769-1780.
  29. Fontenot J.D., Rasmussen J.P., Williams L.M. et al. Regulatory T cell lineage specification by the forldiead transcription factor Foxp3 // Science. 2003. Vol. 299. P. 1057-1061.
  30. Fontenot J.D., Rasmussen J.P., Williams L.M. et al. Regulatory T cell lineage specification by the forkhead transcription factor Foxp3 // Immunity. 2005. Vol. 22. P. 329-341.
  31. Furuichi Y., Tolcuyama H., Ueha S. Depletion of CD25+CD4+ T cells (Tregs) enhances the HBV-spe- cific CD8+ T cell responce primed by DNA immunization // Wld. J. Gastroenterol. 2005. Vol. 11. P. 3772- 3777.
  32. Gambineri E., Torgerson T.R., Ochs H.D. Immune dys-regulation, polyendocrinopathy, enteropathy, and X- linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis // Curr. Opin. Rheumatol. 2003. Vol. 15. P. 430-435.
  33. Gavin M.A., Rasmussen J.P., Fontenot J.D. et al. Foxp3-dependent programme of regulatory T-cell differentiation//Nature. 2007. Vol. 445. P. 771-775.
  34. Gavin M., Rudensky A. Control of immune homeostasis by naturally arising regulatory CD4+ T cells // Curr. Opin. Immunol. 2003. Vol. 15. P. 690-696.
  35. Gondek D.C., Lu L-F., Quezada S.A. et al. Cutting edge: contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism // J. Immunol. 2005. Vol. 174. P. 1783-1786.
  36. Heier I., Hofgaard P.O., Brandtzag P. et al. Depletion of CD25+CD4+ regulatory T cells inhibits local tumour growth in a mouse model of В cell lymphoma // Clin. Exp. Immunol. 2008. Vol. 152. P. 381-387.
  37. Hori S., Nomura T., Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3 // Science. 2003. Vol. 299. P. 1057-1061.
  38. Huang C.T. et al. Role of LAG-3 in regulatory T cells // Immunity 2004. Vol. 21. P. 503-513.
  39. Joetham A. Naturally occurring lung CD4(+)CD25(+) T cell regulation of ail-way allergic responses depends on IL-10 induction of TGF-beta // J. Immunol. 2007. Vol. 178. P. 1433-1442.
  40. Kelchtermans H., De Klerck B., Mitera T. Defective CD4+CD25+ regulatory T cell functioning in collagen-induced arthritis an important factor in pathogenesis, counter-regulated by endogenous IFN-gamma // Arthr. Res. Ther. 2005. Vol. 7. № 2. P. 402^115.
  41. Khattri R., Cox T., Yasayko S.A. et al. An essential role for Scurfin in CD25+CD4+ T regulatory cells // Nat. Immunol. 2003. Vol. 4. P. 337-342.
  42. Kohno T., Yamada Y., Akamatsu N. Possible origin of adult T-cell leukemia/lymphoma cells from human T lymphotropic virus type-1-infected regulatory T cells // Cancer. Sci. 2005. Vol. 96. P. 527-533.
  43. Kojima H., Kaimo Y., Hase H. et al. CD4+CD25+ regulatory T cells attenuate the phosphatidylinositol 3-lci- nase/Alet pathway in antigen-primed immature CD 8+ CTLs during functional maturation // J. Immunol. 2005. Vol. 174. P. 5959-5967.
  44. Levings M.K., Roncarolo M.G. T-regulatory cells: a novel subset of CD4 T cells with immunoregulatory properties// J. Allergy. Clin. Immunol. 2000. Vol. 106. P. 109-112.
  45. Liang B. et al. Regulatory T cells inhibit dendritic cells by LAG-3 engagement of MHC class II // J. Immunol. 2008. Vol. 180. P.5916-5926.
  46. Lim. H.W., Hillsamer P., Banhem A.H. et al. Cutting edge: direct suppression of В cells by CD4+CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus // J. Exp. Med. 2005. Vol. 201. P. 127-137.
  47. Loser K. IL-10 controls ultraviolet-induced carcinogenesis in mice // J. Immunol. 2007. Vol. 179. P. 365-371.
  48. Lundgren A., Stromberg E., Sjorling A. Mucosal FOXP3-expressing CD4+CD25high regulatory T cells in Helicobacter pylori-infected patients // Infect, and Immunol. 2005. Vol. 73. P. 523-531.
  49. McGuirk R, Mills K.H. Pathogen-specific regulatory T cells provoke a shift in the Thl/Th2 paradigm in immunity to infectious diseases // Trends Immunol. 2002. Vol. 23. P. 450^155.
  50. Mellor A.L., Munn D.H. IDO expression by dendritic cells: tolerance and tryptophan catabolism // Nat. Rev. Immunol. 2004. Vol. 4. P 762-774.
  51. Monk C.R., Spachidou M., Rovis F. MRL/Mp CD4+ CD25- T cells show reduced sensitivity to suppression by CD4+ CD25+ regulatory T cells in vitro: a novel T cell regulation in systemic lupus erythematosis // Ar- thr. and Rheum. 2005. Vol. 52. P. 1180-1184.
  52. Netea M.G., Van der Meer J.W., Kullberg В.J. Toll-like receptors as an escape mechanism from the host defense //Trends. Microbiol. 2004. Vol. 12. P. 484-488.
  53. Nishikawa H., Kato T., Tawara I. et al. Definition of target antigens for naturally occurring CD4+CD25+ regulatory T cells // J. Exp. Med. 2005. Vol. 201 № 5. P 681-686.
  54. Nomura T., Sakaguchi S. Naturally arising CD25+CD4+ regulatory T cells in tumor immunity // Cum. Top. Microbiol. Immunol. 2005. Vol. 293. P. 287-302.
  55. Ou L.S., Goleva E., Hall С. T regulatory cells in atopic dermatitis and subversion of their activity by superantigens // J. Allergy. Clin. Immunol. 2004. Vol. 113. P 756-763.
  56. Ouldca M. Interplay between pathogenic Thl7 and regulatory T cells // Ann. Rheum. 2007. Vol. 66. P 87-90.
  57. Papiemik M., de Moraes M.L., Pontoux C. Regulatory CD4 T cells: expression of IL-2R, resistance to clonal deletion and IL-2 dependency // Int. Immunol. 1998. Vol. 10. P. 371-378.
  58. Paust S., Cantor H. Regulatory T cells and autoimmune disease // Immunol. Rev. 2005. Vol. 204. P. 195-207.
  59. Peng G., Guo Z., Kinawa Y. Toll-like receptor 8-medi- ated reversal of CD4+ regulatory T cell function // Science. 2005. Vol. 309. P. 1380-1384.
  60. Sakaguchi S. Control of immune responses by naturally arising CD4+ regulatory T cells that express toll-like receptors // J. Exp. Med. 2003. Vol. 197. P. 397-401.
  61. Sakaguchi S. Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses // Annu. Rev. Immunol. 2004. Vol. 22. P. 531-562.
  62. Sakaguchi S., Sakaguchi N, Shimuzu J. Immunologic tolerance maintained by CD25+CD4+ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance // Immunol. Rev. 2001. Vol. 182. P. 18-32.
  63. Sasaki Y., Sakai M., Miyazaki S. Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases // Mol. Hum. Reprod. 2004. Vol. 10. P. 347-353.
  64. Shevach E.M. CD4+CD25+ suppressor T cells: more questions than answers // Nat. Rev. Immunol. 2002. Vol. 2. P 389-400.
  65. Shevach E.M. From vanilla to 28 flavors: multiple varieties of T regulatory cells // Immunity. 2006. ѴЫ. 25. P. 195-201.
  66. Shi H.Z., Li S., Xie Z.F. Regulatory CD4+CD25+ T lymphocytes in peripheral blood from patients with atopic asthma // Clin. Immunol. 2004. ѴЫ. 113. P. 172- 178.
  67. Singh B., Read S., Asseman C. Control of intestinal inflammation by regulatory T cells // Immunol. Rev. 2001. Vol. 18. P. 190-200.
  68. Suciu-Foca N., Manavalan J.S., Scotto L. Molecular characterization of allospecific T suppressor and tolerogenic dendritic cells review // Int. Immunophar- macol. 2005. Vol. 5. P.7-11.
  69. Takahashi T., Kuniyasu Y., Toda M. Immunologic selftolerance maintained by CD25+CD4+ naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive stat // Int. Immunol. 1998. Vol. 10. P. 1969-1980.
  70. Takahashi T., Tagami T., Yamazaki S. Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4 // J. Exp. Med. 2000. Vol. 192. P. 303-310.
  71. Thornton A.M., Shevach E.M. CD4+CD25+ immuno- regulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production // J. Exp. Med. 1998. Vol. 188. P. 287-296.
  72. Тока F.N., Suvas S., Rouse B.T. CD4+CD25+ T cells regulate vaccine-generated primary and memory CD8+ T-cell responses against herpes simplex virus type 1 // J. Virol. 2004. Vol. 78. P. 13082-13089.
  73. Tsunemi S., Iwasaki T., Imado T. Relationship of CD4+CD25+ regulatory T cells to immune status in HIV-infected patients //AIDS. 2005. Vol. 19. P. 879- 886.
  74. Tzankov A., Meier C., Hirschmann P. et al. Correlation of high numbers of intratumoral FOXP3+ regulatory T cells with improved survival in germinal center-like diffuse large В-cell lymphoma, follicular lymphoma and classical Hodgkin's lymphoma // Haematologica. 2008. 193. Vol. 93. № 2. P. 193-200.
  75. Vignali A.A.D., Collison L.W., Workman C.J. How regulatory T cells work // Nat. Rev. Immunol. 2008. Vol. 8. № 7. p. 523-532.
  76. Waldmann H., Graca L., Cobbold S. Regulatory T cells and organ transplantation // Semin. Immunol. 2004. Vol. 16. P. 119-126.
  77. Watanabe N., Wang Y.H., Lee H.K. Hassal's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus //Nature.'2005. Vol. 436. P. 1181-1185.
  78. Weiss L., Donkova-Petrini V, Caccavelli L. Human immunodeficiency virus-driven expansion of CD4+CD25+ regulatory T cells, which suppress HIV-specific CD4 T-cell responses in HIV-infected patients // Blood. 2004. Vol. 104. P. 3249-3256.
  79. Woo E.I., Yeh H., Chu C.S. Cutting edge: Regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation // J. Immunol. 2002. Vol. 168. P. 4272-4276.
  80. Workman C.J., Vignali D.A.A. Negative regulation of T cell homeostasis by LAG-3 // J. Immunol. 2004. Vol. 174. P. 688-695.
  81. Yang Z.-Z., Novak A.J., Ziesmer S.C. et al. Attenuation of CD8+ T-cell function by CD4+CD25+ regulatory T cells in В-cell non-Hodgkin's lymphoma // Cancer. Res. 2006. Vol. 66. № 20. P 10145-10152
  82. Yang Z.-Z., Novak A. J., Ziesmer S.C. et al. CD70+ non- Hodgkin lymphoma В cells induce Foxp3 expression and regulatory function in intratumoral CD4+CD25“ T cells // Blood. 2007. Vol. 100. P. 2537-2544.
  83. Zarek P.E. A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells // Blood. 2008. Vol. 111. P.251-259.
  84. Zelenay S., Lopez-Carvalho T., Caramalho I. Foxp3+ CD25~ cD4 T cells constitute a reservoir of committed regulatory cells that regain CD25 expression upon homeostatic expansion // Proc. Natl. Acad. Sci. USA. 2005. Vol. 102. P. 4091-4096.
  85. Zencluzeen A.C. CD4+CD25+ T regulatory cells in murine pregnancy// J. Reprod. Immunol. 2005. Vol. 102. P. 4091^1096.
  86. Zhao D.M., Thornton A.M., DiPaolo R.J. et al. Activated CD4+CD25+ T cells selectively kill В lymphocytes //Blood. 2006. Vol. 107. P. 3925-3932.
  87. Zheng S.G., Wang J.H., Gray J.D. Natural and induced CD4+CD25+ cells educate CD4+CD25" to develop suppressive activity: the role of IL-2, TGF-beta and IL-10 //J. Immunol. 2004. Vol. 172. P. 5213-5221.

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