The role of naturally occurring regulatory CD4 +CD25 + T-cell subpopulation in the normal state and in various diseases


Naturally occurring regulatory CD4 +CD25 + T cells (Treg cells) play a crucial role in the maintenance of normal immunohomeostasis.T reg cells suppress the activity of effector T cells thus taking part in the prevention of the development of autoimmune processes, whereas the inhibition of Treg cells activity can lead to the manifestation of severe or even fatal autoimmune and lymphoproliferative diseases. It has been shown that CD4 +CD25 +Treg cells play an important role in the suppression of graft-versus-host reaction, in the prevention of the development of allergic disorders and in the suppression of immune response to opportunistic pathogens. In patients with malignant neoplasms T reg cells inhibit the productive immune response against tumor.

O V Akinfleva


L N Bubnova

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