Ожирение и атеросклероз: роль адипокпнов



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Обзор посвящен анализу данных о роли адипокинов в атерегенезе. Увеличение массы жировой ткани сопровождается развитием инсулинорезистентности, дислипопротеинемии и гипертензии, мощным атерогенным фактором. Кроме того, в последние годы накоплены сведения о прямом воздействии ряда провоспалительных адипокинов, продукция которых резко увеличивается при ожирении, на клетки артериальной стенки (эндотелиальные и гладкомышечные клетки, макрофаги). Эти адипокины способствуют развитию дисфункции эндотелия и формированию атеросклеротических поражений.

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А Д Денисенко

ГУ «Научно-исследовательский институт экспериментальной медицины СЗО РАМН»

Email: 49-07. е: mail: add@iem.sp.ru
Отдел биохимии

Список литературы

  1. Нагорнев В.А. Патогенез атеросклероза. СПб.: Хромус, 2006. 240 с.
  2. Arita Y., Kihara S., Ouchi N. et al. Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expressionin human monocyte-derived macrophages // Circulation. 2001. Vol. 103. P. 1057-1063.
  3. Artwohl M., Roden M., Holzenbein T. et al. Modulation by leptin of proliferation and apoptosis in vascular endothelial cells // Int. J. Obes. Relat. Metab. Disord. 2002. Vol. 26. P. 577-580.
  4. Bhagar K. and Vallance P. Inflammatory cytokines impairs endothelium-dependent dilatation in human veins in vivo // Circulation. 1997. Vol. 96. P. 3042-3047.
  5. Bodary P.F., Shen Y., Ohman V. et al. Leptin regulates neointima formation after arterial injury through mechanisms independent of blood pressure and the leptin receptor/STAT3 signaling pathways involved in energy balance // Arterioscler. Thromb. Vase. Biol. 2007. Vol. 27. P. 70-76.
  6. Bouloumie A., Marumo T., Lafontan M. and Busse R. Leptin induces oxidative stress in human endothelial cells//FASEB J. 1999. Vol. 13. P. 1231-1238.
  7. Brownlee M. Biochemistry and molecular biology of diabetic complications // Nat. Med. 2001. Vol. 414. P. 813-820.
  8. Calabro P., Samudio I., Willerson J.T. and Yeh E.T. Resistin promotes smooth muscle cell proliferation through activation of extracellular signal-regulated kinase 1/2 and phosphatidylinositol 3-kinase pathways // Circulation. 2004. Vol. 110. P. 3335-3340.
  9. Choy J.C., Granville D.J., Hunt D.W. and McManus B.M. Endothelial cell apoptosis: biochemical char acteristics and potential implications for atherosclerosis//J. Mol. Cell. Cardiol. 2001. Vol. 33. P. 1673- 1690.
  10. Cooke J.P. and Oka R.K. Does leptin cause vascular disease?//Circulation. 2002. Vol. 106. P. 1904- 1905.
  11. Esposito K., Pontillo A., Di Palo C. et al. Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial //JAMA. 2003. Vol. 289. P. 1799-1804.
  12. Havel P.J. Update on adipocyte hormones. Regulation of energy balance and carbohydrate/lipid metabolism H Diabetes. 2004. Vol. 53. Suppl. 1. P. S143- S151.
  13. Heilbronn L.K., Noakes M. and Clifton P.M. Energy restriction and weight loss on very-low-fat diets reduce C-reactive protein concentrations in obese, healthy women // Arterioscler. Thromb. Vase. Biol. 2001. Vol. 21. P. 968-970.
  14. Hermann C., Assmus В., Urbich C. et al. Insulinmediated Stimulation of protein kinase Akt: a potent survival signaling cascade for endothelial cells // Arterioscler. Thromb. Vase. Biol. 2000. Vol. 20. P. 402-409.
  15. Hubert H.B., Feinleib M., McNamara P.M. and Castelli W.P. Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study // Circulation. 1983. Vol. 67. P. 968-977.
  16. Inoguchi T., Li P., Umeda F. et al. High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells // Diabetes. 2000. Vol. 49. P. 1939-1945.
  17. Kohler H.P. and Grant P.J. Plasminogen activator inhibitor type 1 and coronary artery disease // N. Engl. J. Med. 2000. Vol. 342. P. 1792-1801.
  18. Konstantinides S., Schafer K., Koschnick S., and Loskutoff D.J. Leptin dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity // J. Clin. Invest. 2001. Vol. 108. P. 1533-1540.
  19. Kubota N., Terauchi Y., Yamauchi T. et ai. Disruption of adiponectin causes insulin resistance and neointimal formation // J. Biol. Chem. 2002. Vol. 277. P. 25863-25866.
  20. Lau D.C.W., Dhillon B., Yan H. et al. Adipokines: molecular links between obesity and atherosclerosis//Am. J. Physiol. Heart Circ. Physiol. 2005. Vol. 288. P. H2031-H2041.
  21. Lau D., Yan H., Abdel-Hafez M., Kermouni A. Adipokines and the paracrine control of their production in obesity and diabetes // Int. J. Obes. Relat. Metab. Disord. 2002. Vol. 26. P. Sill.
  22. Loffreda S., Yang S.Q. and Lin H.Z. Leptin regulates proinflammatory immune responses// FASEB J. 1998. Vol. 12. P. 57-65.
  23. Mohamed-Ali V., Goodrick S., Ravvesh A. et al. Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha. in vivo //.1. Clin. Endocrinol. Metab. 1997. Vol. 82. P. 4196-4200.
  24. Nickenig G. and Harrison D.G. The ATI-type angiotensin receptor in oxidative stress and atherogenesis. Pan I: oxidative stress and atherogenesis // Circulation. 2002. Vol. 105. P. 393-396. "
  25. Okamoto Y., Kihara S., Ouchi N. et al. Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice // Circulation. 2002. Vol. 106. P. 2767-2670.
  26. O'Rourke L., Gronning L.M., Yeaman S.I. and Shepherd P.R. Glucosedependent regulation of cholesterol ester metabolism in macrophages by insulin and leptin // J. Biol. Chem. 2002. Vol. 277. P. 42557-42562.
  27. Ouchi N., Kihara S., Arila Y. et al. Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin // Circulation. 1999. Vol. 100. P. 2473-2476.
  28. Ouchi N., Kihara S., Arita Y. et al. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NFkappaB signaling through a cAMP-dependent pathway // Circulation. 2000. Vol. 102. P. 1296-1301.
  29. Ouchi N., Kihara S., Funahashi T. et al. Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue // Circulation. 2003. Vol. 107. P. 671-674.
  30. Park H.Y., Kwon H.M., Lim H.J. et al. Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metal-loproteinases in vivo and in vitro // Exp. Mol. Med. 2001. Vol. 33. P. 95-102.
  31. Pasceri V., Willerson J.T., and Yeh E.T. Direct pro-inflammatory effect of C-reactive protein on human endothelial cells // Circulation. 2000. Vol. 102. P. 2165-2168.
  32. Quehenberger P., Exner M., Sunder-Plassmann R. et al. Leptin induces endothelin-1 in endothelial cells in vitro // Circ. Res. 2002. Vol. 90. P. 711-718.
  33. Ridker P.M. Clinical application of C-reactive protein for cardiovascular disease detection and prevention // Circulation. 2003. Vol. 107. P. 363-369.
  34. Rimm E.B., Stampfer M.J., Giovannucci E. et al. Body size and fat distribution as predictors of coronary heart disease among middle-aged and older US men // Am. J. Epidemiol. 1995. rol. 141. P. 1117-1127.
  35. Sierra-Honigmann M.R., Nath A.K., Murakami C. et al. Biological action of leptin as an angiogenic factor// Science. 1998. Vol. 281. P. 1683-1386.
  36. Steppan C.M., Bailey S.T., Bhat S. et al. The hormone resistin links obesity to diabetes // Nature. 2001. Vol. 409. P. 307-312.
  37. Tham D.M., Martin-McNulty B., Wang Y.X. et al. Angiotensin II is associated with activation of NF-_B-associated genes and downregulation of PPARs // Physiol. Genomics. 2002. Vol. 11. P 21 30.
  38. Verma S. and Anderson T.J. Fundamentals of endothelial function for the clinical cardiologist // Circulation. 2002. Vol. 105. P 546-549.
  39. Verma S., Li S.FI., Badiwala M.V. et al. Endothelin antagonism and interleukin-6 inhibition attenuate the proatherogenic effects of C-reactive protein // Circulation. 2002. Vol. 105. P. 1890-1896.
  40. Verma S., Li S.H., Wang C.H. et al. Resistin promotes endothelial cell activation: further evidence of adipokine-endothclial interaction // Circulation. 2003. Vol. 108. P. 736-740.
  41. Verma S., Wang C.H., Li S.H. et al. A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis // Circulation. 2002. Vol. 106. P. 913-919.
  42. Verma S., Wang C.H., Weisel R.D. et al. Hyperglycemia potentiates the proatherogenic effects of C-reactive portein: reversal with rosiglitazone // J. Mol. Cell Cardiol. 2003. Vol. 35. P. 417-419.
  43. Visser M., Bouter L.M., McQuillan G.M. et al. Elevated C-reactive protein levels in overweight and obese adults // JAMA. 1999. Vol. 282. P. 2131-2135.
  44. Wajchenberg B.L. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome // Endocr. Rev. 2000. Vol. 21. P. 697-738.
  45. Wang P., Ba Z.F. and Chaudry I.H. Administration of tumor necrosis factor-alpha in vivo depresses endothelium-dependent relaxation !/ Am. J. Physi ol. Heart. Circ. Physiol. 1994. Vol. 266. P. H2535-H2541.
  46. Wang C.H., Li S.H., Weisel R.D. et al. C-reactive protein upregulates angiotensin type 1 receptors in vascular smooth muscle // Circulation. 2003. Vol. 107. P. 1783-1790.
  47. Yamagishi S.I., Edelstein D., Du X.L. et al. Leptin induces mitochondrial Superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A // J. Biol. Chem. Vol. 276. P. 25096-25100.
  48. Yamauchi T., Kamon J., Waki H. et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity // Nat. Med. 2001. Vol. 7. P. 941 -946.

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