Obesity and atherosclerosis: role of adipokines


This review summarizes the experimental and clinical data on the role of adipokines in atherogenesis. Excess body fat accompanies by insulin resistance, dislipoproteinemias and hypertension, promoting atherosclerosis lesions formation. Elevation plasma level of proinflammatory adipokines in obesity provide the conditions for their direct effect on arterial wall cells, such as endothelial cells, smooth muscle cells and macrophages. In general, influence these adipokines leads to endothelial dysfunction and promotion of atherosclerosis lesions formation.

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A D Denisenko

Email: 49-07. е: mail: add@iem.sp.ru


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