Apolipoprotein A-I in the human monocyte/macrophage cell lines: the expression and the putative functions



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This review outlines the modern concepts concerning functions of high density lipoproteins and their major protein component apolipoprotein А-I (ApoA-l) in the development of atherosclerotic lesions. The discussion of anti-inflammatory ApoA-l activity as well as the regulation of apoA-l gene expression by proinflammatory cytokine TNFa is underlined. There are original data about the expression of apoA-l gene in human monocyte-macrophage lineages. Stimulation of human monocytes and macrophages by TNFa leads to an activation of apoA-l expression in those cells in contrast to the effect of TNFa on human hepatocytes and enterocytes, where there is a downregulation of apoA-l expression. The putative functions of ApoA-l synthesized by macrophages are discussed, in particular the stabilization effect of ApoA-l on ABCA1 transporter which possesses the antiatherogenic properties.

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