Apolipoprotein A-I in the human monocyte/macrophage cell lines: the expression and the putative functions
- Authors: Orlov SV1, Mogilenko DA1, Perevozchikov AP1
-
Affiliations:
- Issue: Vol 10, No 4 (2010)
- Pages: 50-62
- Section: Articles
- Published: 15.12.2010
- URL: https://journals.eco-vector.com/MAJ/article/view/10084
- DOI: https://doi.org/10.17816/MAJ10450-62
- ID: 10084
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Abstract
This review outlines the modern concepts concerning functions of high density lipoproteins and their major protein component apolipoprotein А-I (ApoA-l) in the development of atherosclerotic lesions. The discussion of anti-inflammatory ApoA-l activity as well as the regulation of apoA-l gene expression by proinflammatory cytokine TNFa is underlined. There are original data about the expression of apoA-l gene in human monocyte-macrophage lineages. Stimulation of human monocytes and macrophages by TNFa leads to an activation of apoA-l expression in those cells in contrast to the effect of TNFa on human hepatocytes and enterocytes, where there is a downregulation of apoA-l expression. The putative functions of ApoA-l synthesized by macrophages are discussed, in particular the stabilization effect of ApoA-l on ABCA1 transporter which possesses the antiatherogenic properties.
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About the authors
S V Orlov
Email: serge@iem.sp.ru
D A Mogilenko
A P Perevozchikov
Email: app@iem.sp.ru
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