Cognitive function in patients with myasthenia gravis



Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The study presents the results of a complex neuropsychological examination of patients with myasthenia gravis, which revealed intellectual disorders in 36.6% of cases, i.e., violations of memory processes, decreasing short-term memory level, and rapid deterioration of attention. A study of patients with myasthenia gravis with thymoma (before thymectomy) and patients with disease duration of more than 10 years found more pronounced memory and attention disorders (р < 0.05).

Full Text

Restricted Access

About the authors

S A Nalkin

North-Western State Medical University named after I.I. Mechnikov

S V Lobzin

North-Western State Medical University named after I.I. Mechnikov

M G Sokolova

North-Western State Medical University named after I.I. Mechnikov

References

  1. Санадзе А.Г. Миастения и миастенические синдромы. - 2-е изд. - М.: ГЭОТАР-Медиа, 2017. [Sanadze AG. Miasteniya i miastenicheskie sindromy. 2nd ed. Moscow: GEOTAR-Media; 2017. (In Russ.)]
  2. Миастения: диагностика и лечение / Под ред. С.В. Лобзина. - СПб.: СпецЛит, 2015. [Miasteniya i miastenicheskie sindromy. Ed by S.V. Lobzin. Saint Petersburg: SpetsLit; 2015. (In Russ.)]
  3. Косачев В.Д., Алексеева Т.М., Лобзин С.В., и др. Отдаленные результаты хирургического лечения миастении // Вестник Северо-Западного государственного медицинского университета им. И.И. Мечникова. - 2016. - Т. 8. - № 3. - С. 19-23. [Kosachev VD, Alekseeva TM, Lobzin SV, et al. Long-term results of surgical treatment of myasthenia. Herald of the Northwestern State Medical University named after I.I. Mechnikov. 2016;8(3):19-23. (In Russ.)]
  4. Косачев В.Д., Соколова М.Г. Миастения (клиническая картина, диагностика, лечение). - СПб.: Изд-во СЗГМУ им. И.И. Мечникова, 2013. [Kosachev VD, Sokolova MG. Miasteniya (klinicheskaya kartina, diagnostika, lechenie). Saint Petersburg: Izdatel’stvo SZGMU im. I.I. Mechnikova; 2013. (In Russ.)]
  5. Joshi D, Bhatia M, Gupta S, et al. Cognitive evaluation in myasthenia gravis: A P300 and neuropsychological study. Neurol Asia. 2006;(11):97-102.
  6. Yakel JL. Cholinergic receptors: functional role of nicotinic ACh receptors in brain circuits and disease. Pflugers Arch. 2013;465(4):441-450. doi: 10.1007/s00424-012-1200-1.
  7. Wonnacott S, Bermudez I, Millar NS, Tzartos SJ. Nicotinic acetylcholine receptors. Br J Pharmacol. 2018;175(11):1785-1788. doi: 10.1111/bph.14209.
  8. Kaltsatou A, Fotiou D, Tsiptsios D, Orologas A. Cognitive impairment as a central cholinergic deficit in patients with Myasthenia Gravis. BBA Clin. 2015;3:299-303. doi: 10.1016/j.bbacli.2015.04.003.
  9. Hamed S, Mohamed M, Youssef A, et al. Assessment of cognitive function in patients with myasthenia gravis. Neuroimmunol Neuroinflamm. 2014;1(3):141. doi: 10.4103/2347-8659.143671.
  10. Marra C, Marsili F, Quaranta D, Evoli A. Determinants of cognitive impairment in elderly myasthenia gravis patients. Muscle Nerve. 2009;40(6):952-959. doi: 10.1002/mus.21478.
  11. Eizaguirre MB, Aguirre F, Yastremiz C, et al. Neuropsychological performance in patients with myasthenia gravis. Medicina. 2017;77(2):117-120.
  12. Paul RH, Cohen RA, Gilchrist JM, et al. Cognitive dysfunction in individuals with myasthenia gravis. J Neurol Sci. 2000;179(1-2):59-64. doi: 10.1016/s0022-510x(00)00367-1.
  13. Mao Z, Yin J, Lu Z, Hu X. Association between myasthenia gravis and cognitive function: A systematic review and meta-analysis. Ann Indian Acad Neurol. 2015;18(2):131-137. doi: 10.4103/0972-2327.156560.
  14. Jordan B, Schweden TLK, Mehl T, et al. Cognitive fatigue in patients with myasthenia gravis. Muscle Nerve. 2017;56(3):449-457. doi: 10.1002/mus.25540.
  15. Соколова, М.Г., Лобзин С.В., Никишина О.А., и др. К вопросу о патогенезе когнитивных расстройств при мышечной дистрофии Дюшенна в клинико-лабораторном и молекулярно-генетическом исследовании // Журнал неврологии и психиатрии им. С.С. Корсакова. - 2017. - Т. 117. - № 12. - С. 78-84. [Sokolova MG, Lobzin SV, Nikishina OA, et al. Pathogenesis of cognitive disorders in patients with Duchenne muscular dystrophy. Zh Nevrol Psikhiatr Im S S Korsakova. 2017;117(12):78-84. (In Russ.)]
  16. Kurlowicz L, Wallace M. The Mini-Mental State Examination (MMSE). J Gerontol Nurs. 1999;25(5):8-9. doi: 10.3928/0098-9134-19990501-08.
  17. Cunha PJ, Nicastri S, de Andrade AG, Bolla KI. The frontal assessment battery (FAB) reveals neurocognitive dysfunction in substance-dependent individuals in distinct executive domains: Abstract reasoning, motor programming, and cognitive flexibility. Addict Behav. 2010;35(10):875-881. doi: 10.1016/j.addbeh.2010.05.005.
  18. Manos PJ. 10-Point Clock Test Screens for Cognitive Impairment in Clinic and Hospital Settings. Psychiatr Times. 1998;15(10):18-21.
  19. Вартанов А.В., Козловский С.А., Скворцова В.Б., и др. Память человека и анатомические особенности гиппокампа // Вестник Московского университета. Серия 14: Психология. - 2009. - № 4. - С. 3-16. [Vartanov AV, Kozlovskiy SA, Skvortsova VB, et al. Human memory and anatomic features of the hippocampus. Vestnik Moskovskogo universiteta. Seriya 14: Psikhologiya. 2009;(4):3-16. (In Russ.)]
  20. Ахметзянова А.И. Практикум по клинической психологии. Учебно-методическое пособие. - М.: Школьная пресса, 2013. [Akhmetzyanova AI. Praktikum po klinicheskoy psikhologii. Uchebno-metodicheskoe posobie. Moscow: Shkol’naya pressa; 2013. (In Russ.)]
  21. Малкина-Пых И.Г. Психосоматика: Справочник практического психолога. - М.: Эксмо, 2005. [Malkina-Pykh IG. Psikhosomatika: Spravochnik prakticheskogo psikhologa. Moscow: Eksmo; 2005. (In Russ.)]

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2018 Nalkin S.A., Lobzin S.V., Sokolova M.G.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 74760 от 29.12.2018 г.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies