Белок щелевых контактов коннексин-43 и его распределение в разных тканях

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Аннотация

Коннексины — белки, образующие у позвоночных межклеточные щелевые контакты, способствующие передаче малых молекул между клетками. Коннексин-43 — основной представитель семейства коннексинов в человеческом организме. Его функции в клетке разнообразны, он обнаружен в самом большом количестве тканей и клеток по сравнению с другими представителями семейства коннексинов. Наиболее интенсивно изучается его роль в межклеточных взаимодействиях, а также особенности выполняемых функций в жизненно важных органах — в сердце и мозге. В связи с высокой распространенностью в разных тканях в данный момент существует большой массив разрозненных экспериментальных данных, которые сложно собрать в единую картину. Данная работа ставит своей целью обобщить литературные данные об особенностях распределения и функциях коннексина-43 в различных тканях и о дальнейших перспективах изучения этого белка.

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Михаил Сергеевич Филиппов

Институт экспериментальной медицины

Email: msfilippov@mail.ru
SPIN-код: 7789-7219

лаборант-исследователь лаборатории функциональной морфологии центральной и периферической нервной системы отдела общей и частной морфологии

Россия, Санкт-Петербург

Дмитрий Эдуардович Коржевский

Институт экспериментальной медицины

Автор, ответственный за переписку.
Email: DEK2@yandex.ru
ORCID iD: 0000-0002-2456-8165
SPIN-код: 3252-3029

д-р мед. наук, профессор РАН, заведующий лабораторией функциональной морфологии центральной и периферической нервной системы отдела общей и частной морфологии

Россия, Санкт-Петербург

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