Potential of surgery in treatment of multiple metastatic pulmonary lesions



Cite item

Full Text

Abstract

Metastatic pulmonary lesions are present in 30-50% of patients that die because of malignant neoplasms. Approaches to treatment of this condition accepted at present as standard can hardly be considered effective. Based on the review of literature and personal clinical experience of surgical treatment of more than 300 patients with multiple metastatic pulmonary lesions, he author discusses variants of pathogenesis of metastatic process, justifies the appropriateness of surgical stage in complex treatment of metastatic pulmonary neoplasms, describes the principles of assessment of patients with multiple pulmonary metastases, resectability criteria, features of surgery, locoregional therapeutic techniques that exist now and are being developed, postsurgical adjuvant therapy, immediate and long-term results of complex treatment.

Full Text

Restricted Access

About the authors

V A Tarasov

Medical Academy of Postgraduate Edication, St. Petersburg

References

  1. Елисеев В.Г., Афанасьев Ю.И., Котовский Е.Ф., Яцковский А.Н. Атлас микроскопического и ультрамикроскопического строения клеток, тканей и органов. М.: Медицина, 2004.
  2. Ерохин В.В., Романова Л.К. Клеточная биология легких в норме и при патологии. М.: Медицина, 2000.
  3. Al-Mehdi А.В., Tozawa К., Fisher А.В. et al. Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis //Nature: Medicine. 2000. Vol. 6. P. 100-102.
  4. Alpaugh M.L., Tomlinson J.S., Kasraeian S. et al. A novel human xenograft of inflammatory breast cancer // Cancer Res. 1999. Vol. 59. P. 5079-5084.
  5. Ausprunk D.H. Synthesis of glycoproteins by endothelial cells in embryonic blood vessels // Dev. Biol. 82. Vol. 90. P. 79-90.
  6. Cifone M.A., Fidler I.J. Increasing metastatic potential is associated with increasing genetic instability of clones isolated from murine neoplasms // Proc. Natl. Acad. Sci. USA. 1981. Vol. 78. P. 6949-6952.
  7. Fidler I.J. Metastasis: quantitative analysis of distribution and fate of tumor embolilabeled with 125 I-5-iodo2'-deoxyuridine // J. Natl. Cancer Inst. 1970. Vol. 45. P. 773-782.
  8. Fidler I J. Critical factors in the biology of human cancer metastasis. Twenty-eighth G.H.A. Glowes memorial award lecture // Cancer Res. 1999. Vol. 50. № 61. P. 30-38.
  9. Fidler I.J., Kripke M.L. Metastasis results from preexisting variant cells within a malignant tumor // Science. 1977. Vol. 197. P. 893-895.
  10. Folkman J., D'Amore PA. Blood vessel formation: what is its molecular basis? // Cell. 1996. Vol. 87. P. 1153-1155.
  11. Hanahan D. Signaling vascular morphogenesis and maintenance // Science. 1997. Vol. 277. P. 48-50.
  12. Harris A.L. Hypoxia - a key regulatory factor in tumor growth // Nat. Rev. Cancer. 2002. Vol. 2. P. 38-47.
  13. Hart I.R., Fidler I.R. Role of organ selectivity in the determination of metastatic pattern of В16 melanoma // Cancer Res. 1980. Vol. 40. P. 2281-2287.
  14. Jin K., LaFevre-Bernt M., Sun Y. et al. FGF-2 promotes neurogenesis and neuroprotection and prolongs survival in a transgenic mouse model of Huntingtone's disease // Proc. Natl. Acad. Sci. USA. 2005. Vol. 102. P. 18189-18194.
  15. Kakiuchi S., Daigo Y, Tsunoda T. et al. Genomewide analysis of organ-preferential metastasis of human small cell lung cancer in mice // Mol. Cancer Res. 2003. Vol. LP. 485-499.
  16. Kang Y, Siegel P.M., Shu W. et al. A multigenic program mediating breast cancer metastases to bone // Cancer Cell. 2003. Vol. 3. P. 537-549.
  17. Madri J.A., Pratt B.M., Tucker A.M. Phenotypic modulation of endothelial cells by transforming growth factor-beta depends upon the composition and organization of the extracellular matrix // J. Cell. Biol. 1988. Vol. 106. P. 1375-1384.
  18. Martini N., McCormack P. Evolution of the surgical management of pulmonary metastases // Chest. Surg. Clin. N. Am. 1998. Vol. 8. P. 119-126.
  19. Murphy P.M. Chemokines and the molecular basis of cancer metastasis // N. Engl. J. Med. 2001. Vol. 345. P. 833-835.
  20. Nakamura K., Martin K.C. Jackson J.K. et al. Brainderived neurotrophic factor activation of TrkB induces vascular endothelial growth factor expression via hypoxia-inducible factor-1 alpha in neuroblastoma cells // Cancer Res. 2006. Vol. 66. P. 4249^1255.
  21. Nowell PC. The clonal evolution of tumor cell populations // Science. 1976. Vol. 194. P. 23-28.
  22. OdaN., Abe M., Sato Y. ETS-1 converts endothelial cells to the angiogenic phenotype by inducing the expression of matrix metalloproteinases and integrin b3 //J. Cell. Physiol. 1999. Vol. 178. P. 121-132.
  23. Orlidge A., D'Amore E.A. Inhibition of capillary endothelial cell growth by pericites and smooth muscle cells // J. Cell. Biol. Vol. 105. P. 1455-1462.
  24. Paget S. The distribution of secondary growths in cancer of the breast // Lancet. 1889. Vol. 1. P. 571-573.
  25. Pastorino U, Andreola S., Tagliabue E. et al. Immunocy-tochemical markers in stage 1 lung cancer: relevance to prognosis//J. Clin. Oncol. 1997. Vol. 15. P. 2858-2865.
  26. Pastorino U., Buyse M., Friedel G. et al. Long term result of lung metastasectomy prognostic analyses based on 5206 cases // J. Thorac. Cardiovasc. Surg. 1997. Vol. 113. P. 37-49.
  27. Peters B.A., Diaz LA., Polyak K. et al. Contribution of bone marrow-derived endothelial cells to human tumor vasculature //Nat. Med. 2005. Vol. 11. P. 261-262.
  28. Ramaswamy S., Ross K.N., Lander E.S. et al. A molecular signature of metastasis in primary solid tumors //Nat. Genet. 2003. Vol. 33. P. 49-54.
  29. Rosenblatt M.B., Lisa J.R., Collier F. Primary and metastatic bronchiolo-alveolar carcinoma // Dis. Chest. 1967. Vol. 52. P. 147-152.
  30. Sardari Nia P., van Marck E., van Schil P. The prospect of biologic staging of non-small cell lung cancer // Clin. Lung Cancer. 2005. Vol. 6. P. 217-224.
  31. Sorlie Т., Perou СМ., Tibshirani R. et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications // Proc. Natl. Acad. Sci. USA. 2001. Vol. 98. P. 10869-10874.
  32. Sugarbaker E.V Cancer metastasis: a product of tumor-host interactions // Curr. Probl. Cancer. 1979. Vol. 3.P. 1-59.
  33. Tarin D., Price J.E., Ketfiewell M.G. et al. Clinicopathological observations on metastasis in man studied in patients treated with peritoneovenous shunts // Br. Med. J. [Clin. Res. Ed.] 1984. Vol. 288. P. 749-751a.
  34. Tarin D., Price J.E., Kettlewell M.G. et al. Mechanisms of human tumor metastasis studied in patients with peritoneovenous shunts // Cancer Res. 1984. Vol. 44. P. 3584-3592b.
  35. Van Meerbeeck J.P, Gosselin R., Duyck Ph. Lung Metastases: Epidemiology, Clinical Presentation and Imaging // Lung Metastases and Isolated Lung Perfusion / Editor: P. Van Schil. 2007. P. 3-25.
  36. Wang G.L., Jiang B.H., Rue E.A. et al. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS het-erodimer regulated by cellular 02 tension // Proc. Natl. Acad. Sci. USA. 1995. Vol. 92. P. 5510-5514.
  37. Wiesener M.S., Munchenhagen P.M., Berger I. et al. Constitutive activation of hypoxia-inducible genes related to overexpression of hypoxia-inducible factor-1 alpha in clear-cell renal carcinomas // Cancer Res. 2001. Vol. 61. P. 5215-5222.
  38. Willis R.A. The spread of ttimors in the human body. 3rd ed. London: Butterworths, 1973. P. 170.
  39. Woodard P.K., Dehdashti R, Putman C.E. Radiologic diagnosis of extrathoracic metastases to the lung // Oncology (Huntingt). 1998. Vol. 12. P. 431-438.
  40. Weiser M.R., Downey R.J., Leung D.H. et al. Repeat resection of pulmonary metastases in patients with soft-tissue sarcoma // J. Am. Coll. Surg. 2000. Vol. 191. P. 184-190.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2009 Tarasov V.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 74760 от 29.12.2018 г.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies