THE GENETIC MARKERS OF MALIGNANT GLIOMAS



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Abstract

Advances in genomic technologies provide for a better understanding of the molecular mechanisms of the development of gliomas. The current classification of gliomas is based on their histological features and does not account of the molecular differences between the subtypes of gliomas. High-throughput methods of molecular analysis make it possible to distinguish such subtypes and to suggest novel prognostic criteria. Key genetic alterations having clinical significance reviewed in the present paper include mutations in the genes CIC, FUBP1, IDH1 /IDH2, and ATRX and in TERT gene promoter and 1p/19q co-deletion. These markers may be used in a more accurate classification of gliomas suitable for clinical assessments and therapeutic choices.

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About the authors

A V Kartashev

Russian Research Centre for Radiology and Surgical Technologies; North-Western State Medical University named after I. I. Mechnikov

Email: аrxiator@mail.ru
St. Petersburg, Russia

E I Yakubovich

Russian Research Centre for Radiology and Surgical Technologies

St. Petersburg, Russia

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