Comparative characteristics of antimicrobial activity of water dispersions of silver and gold nanoparticles stabilized with native and synthetic polymers

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BACKGROUND: The construction and application of antimicrobial drugs on the basis of nanoparticles of metals, silver and gold in particular, are staying casual up to now.

AIM: was to study the spectrum of antimicrobial activity of nanoparticles of silver and gold developed by means of chemical recovery and stabilized with native and synthetic compounds.

MATERIALS AND METHODS: The paper presents the results of a study of the antimicrobial activity of aqueous dispersions of silver and gold nanoparticles against standard and clinical strains of Staphylococcus aureus, which were sensitive to methicillin. Natural (carboxymethylcellulose, sodium oleate) and synthetic (polyvinyl alcohol, sodium dodecyl sulfate, polyazolidylammonium modified with iodine hydrate ions) polymeric compounds were used as stabilizers.

RESULTS: The high antistaphylococcal activity of the studied drugs was established, which depended on the stabilizer used. The highest efficiency of biocidal action was revealed for aqueous dispersions of metal nanoparticles stabilized with polyvinyl alcohol and polyazolidylammonium modified with iodine hydrate ions, which did not depend on the strain differences of microorganisms.

CONCLUSIONS: The results obtained open up prospects for the use of aqueous dispersions of silver and gold nanoparticles as active components in the development of new antiseptic preparations and photosensitizers for antimicrobial photodynamic therapy.

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Tatiana A. Shulgina

V.I. Razumovsky Saratov State Medical University

Author for correspondence.
ORCID iD: 0000-0003-2393-6402
SPIN-code: 4148-3558


Russian Federation, 137, Bolshaya Sadovaya st., Saratov, 410000

Kseniya V. Zubova

Saratov State University

ORCID iD: 0000-0002-9406-080X
SPIN-code: 2858-5323

Рostgraduate student

Russian Federation, 137, Bolshaya Sadovaya st., Saratov, 410000

Elena V. Glinskaya

Saratov State University

ORCID iD: 0000-0002-1675-5438
SPIN-code: 2724-1359

Cand. Sci. (Biol.), Аssociate professor

Russian Federation, 137, Bolshaya Sadovaya st., Saratov, 410000

Olga V. Nechaeva

Yuri Gagarin State Technical University

ORCID iD: 0000-0003-3331-1051
SPIN-code: 9984-9594

Dr. Sci. (Biol.), Professor

Russian Federation, 137, Bolshaya Sadovaya st., Saratov, 410000

Natalya V. Bespalova

Yuri Gagarin State Technical University

ORCID iD: 0000-0003-3733-3119
SPIN-code: 1676-8226

Cand. Sci. (Phys. and Math.), Assistant professor

Russian Federation, 137, Bolshaya Sadovaya st., Saratov, 410000


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Copyright (c) 2021 Shulgina T.A., Zubova K.V., Glinskaya E.V., Nechaeva O.V., Bespalova N.V.

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