Comparative characteristics of antimicrobial activity of water dispersions of silver and gold nanoparticles stabilized with native and synthetic polymers

Cover Page


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

BACKGROUND: The construction and application of antimicrobial drugs on the basis of nanoparticles of metals, silver and gold in particular, are staying casual up to now.

AIM: was to study the spectrum of antimicrobial activity of nanoparticles of silver and gold developed by means of chemical recovery and stabilized with native and synthetic compounds.

MATERIALS AND METHODS: The paper presents the results of a study of the antimicrobial activity of aqueous dispersions of silver and gold nanoparticles against standard and clinical strains of Staphylococcus aureus, which were sensitive to methicillin. Natural (carboxymethylcellulose, sodium oleate) and synthetic (polyvinyl alcohol, sodium dodecyl sulfate, polyazolidylammonium modified with iodine hydrate ions) polymeric compounds were used as stabilizers.

RESULTS: The high antistaphylococcal activity of the studied drugs was established, which depended on the stabilizer used. The highest efficiency of biocidal action was revealed for aqueous dispersions of metal nanoparticles stabilized with polyvinyl alcohol and polyazolidylammonium modified with iodine hydrate ions, which did not depend on the strain differences of microorganisms.

CONCLUSIONS: The results obtained open up prospects for the use of aqueous dispersions of silver and gold nanoparticles as active components in the development of new antiseptic preparations and photosensitizers for antimicrobial photodynamic therapy.

Full Text

Restricted Access

About the authors

Tatiana A. Shulgina

V.I. Razumovsky Saratov State Medical University

Author for correspondence.
Email: tshylgina2012@yandex.ru
ORCID iD: 0000-0003-2393-6402
SPIN-code: 4148-3558

biologist

Russian Federation, 137, Bolshaya Sadovaya st., Saratov, 410000

Kseniya V. Zubova

Saratov State University

Email: zubovaksushechka@mail.ru
ORCID iD: 0000-0002-9406-080X
SPIN-code: 2858-5323

Рostgraduate student

Russian Federation, 137, Bolshaya Sadovaya st., Saratov, 410000

Elena V. Glinskaya

Saratov State University

Email: elenavg-2007@yandex.ru
ORCID iD: 0000-0002-1675-5438
SPIN-code: 2724-1359

Cand. Sci. (Biol.), Аssociate professor

Russian Federation, 137, Bolshaya Sadovaya st., Saratov, 410000

Olga V. Nechaeva

Yuri Gagarin State Technical University

Email: olgav.nechaeva@mail.ru
ORCID iD: 0000-0003-3331-1051
SPIN-code: 9984-9594

Dr. Sci. (Biol.), Professor

Russian Federation, 137, Bolshaya Sadovaya st., Saratov, 410000

Natalya V. Bespalova

Yuri Gagarin State Technical University

Email: n.v.bespalova.sstu@gmail.ru
ORCID iD: 0000-0003-3733-3119
SPIN-code: 1676-8226

Cand. Sci. (Phys. and Math.), Assistant professor

Russian Federation, 137, Bolshaya Sadovaya st., Saratov, 410000

References

  1. Namazova-Baranova LS, Baranov AA. Antibiotic Resistance in Modern World. Pediatric Pharmacology. 2017;14(5):341–354. (In Russ.) doi: 10.15690/pf.v14i5.1782
  2. Zeng L, Zhan Z, Hu L, et al. Genetic Characterization of a blaVIM-24-Carrying IncP-7β Plasmid p1160-VIM and a blaVIM-4-Harboring Integrative and Conjugative Element Tn6413 From Clinical Pseudomonas aeruginosa. Front Microbiol. 2019;10:213. doi: 10.3389/fmicb.2019.00213
  3. Vsemirnaya Organizatsiya Zdravookhraneniya [Internet]. Global’naya strategiya VOZ po sderzhivaniyu ustoichivosti k antimikrobnym preparatam ot 2001 [update 2018 April 15]. Available from: https://www.who.int/drugresistance/WHO_Global_Strategy_ Russian.pdf
  4. Strachunskii LS, Kozlov SN. Sovremennaya antimikrobnaya khimioterapiya: rukovodstvo dlya vrachei. Moscow: Borges, 2002. 432 p. (In Russ.)
  5. Shcherbakov AB, Korchak GI, Surmasheva EV. Preparaty serebra: vchera, segodnya i zavtra. Farmatsevticheskii zhurnal. 2006;(5): 45–57. (In Russ.)
  6. Kim JS. Antimicrobial effects of silver nanoparticles. Nanomedecine: Nanotechnology, Biology and Medicine. 2007;3(1):95–101. doi: 10.1016/j.nano.2006.12.001
  7. Kuz’mina LN. Poluchenie nanochastits serebra metodom khimicheskogo vosstanovleniya. Zhurnal Rossiiskogo khimicheskogo obshchestva imeni DI Mendeleeva. 2007;(8):7–12. (In Russ.)
  8. Bukina YuA, Sergeeva EA. Antibakterial’nye svoistva i mekhanizm bakteritsidnogo deistviya nanochastits i ionov serebra. Vestnik Kazanskogo tekhnologicheskogo universiteta. 2012;15(14):170–172. (In Russ.)
  9. Park SJ, Jang YS. Preparation and characterization of activated carbon fibers supported with silver metal for antibacterial behavior. J Colloid Interface Sci. 2003;261(2):238–243. doi: 10.1016/S0021-9797(03)00083-3
  10. Litmanovich OE. Vzaimodeistvie makromolekul s nanochastitsami metallov i psevdomatrichnyi sintez zolei polimer – metallicheskikh nanokompozitov [dissertation abstract]. Moscow, 2006. 32 p.
  11. Nazarchuk OA, Faustova MO, Kolodii SA. Microbiological characteristics of infectious complications, actual aspects of their prevention and treatment in surgical patients. Novosti Khirurgii. 2019;27(3):318–327. (In Russ.) doi: 10.18484/2305-0047.2019.3.318
  12. Tiller JC, Liao C-J, Lewis K, Klibanov AM. Designing surfaces that kill bacteria on contact. Proceedings of the national academy of science. 2001;98(11):5981–5985. doi: 10.1073/pnas.111143098
  13. Kittler S, Greulich C, Diendorf J, et al. Toxicity of Silver Nanoparticles Increases during Storage Because of Slow Dissolution under Release of Silver Ions. Chem Mater. 2010;22(16):4548–4554. doi: 10.1021/cm100023p
  14. Shulgina T, Nechaeva O, Torgashova A., Darin N. Using the method of biotesting to assess the toxicity of waste medical and biological practices containing nanomaterials. IOP Conf. Series: Earth and Environmental Science. 2019;337:012012. doi: 10.1088/1755-1315/337/1/012012
  15. Verkhovskii R, Kozlova A, Atkin V, et al. Physical properties and cytotoxicity of silver nanoparticles under different polymeric stabilizers. Heliyon. 2019;5(3): e01305. doi: 10.1016/j.heliyon.2019.e01305
  16. Pomogailo AD, Rozenberg AS, Uflyand IE. Nanochastitsy metallov v polimerakh. Moscow: Khimiya, 2000. 672 p. (In Russ.)
  17. Federal’nyi tsentr gossanehpidnadzora Minzdrava Rossii. Opredelenie chuvstvitel’nosti mikroorganizmov k antibakterial’nym preparatam: metodicheskie ukazaniya. Moscow: Federal’nyi tsentr gossanehpidnadzora Minzdrava Rossii, 2004. 91 p. (In Russ.)
  18. D’yachenko SV, Kondrashkova IS, Zhernovoi AI. NMR studies of the sedimentation of ferromagnetic nanoparticles in a magnetic fluid. Technical Physics. 2017;87(10):1596–1598. (In Russ.) doi: 10.1134/S1063784217100097
  19. Shulgina TA, Verkhovsky RA, Nechaeva OV, Mylnikov AM. Evaluation of the cytotoxic effect of gold nanoparticles stabilized by polymer compounds on the mouse fibroblast cell culture L929. Problems in medical mycology. 2020;22(3):151. (In Russ.)

Copyright (c) 2021 Shulgina T.A., Zubova K.V., Glinskaya E.V., Nechaeva O.V., Bespalova N.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 65565 от 04.05.2016 г.