Ischemia, reperfusion and preconditioning: traditional and new approaches for treatment of myocardial infarction

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Abstract

The review is devoted to the questions of improvement of the efficacy of myocardial infarction treatment by means of pharmacological drugs possessing pre- or postconditioning effect. The proofs of clinical efficacy of reperfusional therapy of the myocardial infarction are observed using examples of adenosine, activators of KATP channels (diazoxide and nicorandil), opiates (fentanyl, morphine) and some other drugs. The data are analyzed from the point of modern view of molecular mechanisms of hypoxia, the findings of objective laboratory and instrumental control in therapy of myocardial infarction in differend known clinical trials. It is concluded that pharmacological preconditioning is perspective approach in therapy of the acute myocardial infarction both in animal models and in humans.

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About the authors

Abdrei V. Lyubimov

S.M. Kirov Military Medical Academy

Author for correspondence.
Email: a_l17@mail.ru
PhD Russian Federation

Petr D. Shabanov

S.M. Kirov Military Medical Academy

Email: pdshabanov@mail.ru

PhD, Professor

Russian Federation

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