About the influence of metal oxide nanoparticles on living organisms physiology

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Abstract


Recently the number of materials and goods produced by nanotechnology has been growing rapidly, leading to an increased penetration of nanoparticles into biosystems. To assess the risks associated with the production and circulation of nanoproducts should be developed methods for the rapid diagnostics of nanopathology. In this work, it has been experimentally shown that the introduction of metal oxides nanoparticles (TiO2, ZnO, Al2O3, CeO2) to laboratory mice leads to changes some profiles of specific hematological and biochemical blood parameters. Therefore for the purpose of early detection of symptoms of intoxication as benchmarks of the influence of metal oxide nanoparticles on living organisms can recommend express monitoring of peripheral blood (red blood parameters) and biochemical parameters of blood serum (activity of aminotransferases and indicators of nitrogen metabolism). The chosen indicators of blood can serve as diagnostic biomarkers in the development of rapid tests of primary monitoring of the impact of metal oxide nanoparticles on biological systems.

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About the authors

Orkhan А. Zeinalov

LLC “PharmGene Technology”

Author for correspondence.
Email: office@skiff-pharm.ru

Russian Federation PhD

Svetlana P. Kombarova

LLC “PharmGene Technology”

Email: kombarsv@rambler.ru

Russian Federation PhD

Dmitry V. Bagrov

M.V. Lomonosov Moscow State University, Faculty of Biology

Email: dbagrov@gmail.ru

Russian Federation PhD

Mariya A. Petrosyan

D.O. Ott Research Institute of Obstetrics and Gynecology

Email: mariya@labpharm.spb.ru

Russian Federation PhD

Gulrukhsor H. Tolibova

D.O. Ott Research Institute of Obstetrics and Gynecology

Email: gulyatolibova@yandex.ru

Russian Federation MD, PhD

Alexey V. Feofanov

M.V. Lomonosov Moscow State University, Faculty of Biology

Email: avfeofanov@yandex.ru

Russian Federation

PhD, Professor

Konstantin V. Shaitan

M.V. Lomonosov Moscow State University, Faculty of Biology

Email: shaytan49@yandex.ru

Russian Federation

PhD, Professor

References

  1. Абрамян А., Беклемышев В., Вартанов Р., и др. Нанокатализаторы в топливе для транспорта. Нано без границ... // Наноиндустрия. — 2007. — Т. 4. — С. 26–28.
  2. [Abramyan A, Beklemyshev V, Vartanov R, et al. Nanocatalysts in fuel for transport. Nano without borders … Nanoindustry. 2007;4:26-28. (In Russ).]
  3. Медицинские лабораторные технологии / Под ред. А.И. Карпищенко. — СПб.: Интермедика, 2002. — Т. 2. — 600 с. [Medical laboratory technology. Ed by А. Karpishchenko. Saint Petersburg: Intermedica; 2002;2:600 р. (In Russ).]
  4. Методические указания МУ 1.2.2520-09. 1.2. Гигиена, Токсикология, Санитария. Токсиколого-гигиеническая оценка безопасности наноматериалов. — М.: Федеральный центр гигиены и эпидемиологии Роспотребнадзора, 2009. [Methodical instructions MU 1.2.2520-09.
  5. 2. Hygiene, Toxicology, Sanitation. Toxicological and hygienic safety evaluation of nanomaterials. Moscow: Federal Center for Hygiene and Epidemiology of Rospotrebnadzor; 2009. (In Russ).]
  6. Методические указания МУ 1.2.2635-10. 1.2. Гигиена, Токсикология, Санитария. Медико-биологическая оценка безопасности наноматериалов. — М.: Федеральный центр гигиены и эпидемиологии Рос¬потребнадзора, 2010. [Methodical instructions MU 1.2.2635-10. 1.2. Hygiene, Toxicology, Sanitation. Medico-biological safety assessment of nanomaterials. Moscow: Federal Center for Hygiene and Epidemiology of Rospotrebnadzor; 2010. (In Russ).]
  7. Общая токсикология: руководство для врачей / Под ред. А.О. Лойта. — СПб.: ЭЛБИ-СПб, 2006. — 224 с. [General toxicology: a guide for physicians. Ed. by A.О. Loit. Saint Petersburg: ELBI Saint Petersburg; 2006. 224 p. (In Russ).]
  8. Петрицкая Е.Н., Рогаткин Д.А., Абаева Л.Ф., и др. К вопросу о влиянии наночастиц диоксида титана на внутренние органы при пероральном введении у экпериментальных животных // Нанотехника. — 2012. — Т. 2. — С. 84–86. [Petritskаyа Е, Rogatkin D, Abaeva L, et al. To the question about the influence of titanium dioxide nanoparticles on the internal organs when oral administration in an experimental animals. Nanotechnics. 2012;2:84-86. (In Russ).]
  9. Прогноз научно-технологического развития России: 2030. Новые материалы и нанотехнологии / Под ред. Л.М. Гохберга, А.Б. Ярославцева. — М.: Министерство образования и науки Российской Федерации, Национальный исследовательский университет «Высшая школа экономики», 2014. — 52 c. [Forecast of scientific and technological development of Russia: 2030. New materials and nanotechnology. Ed by L. Gokhberg, A. Yaroslavtsev. Moscow: The Ministry of education and science of the Russian Federation, National Research University “Higher School of Economics”; 2014. 52 p.
  10. (In Russ).]
  11. Проданчук Н.Г., Балан Г.М. Нанотоксикология: состояние и перспективы исследований // Современные проблемы токсикологии. — 2011. — № 3–4. — С. 11–27.
  12. [Prodanchuk N, Balan G. Nanotoxicology: status and prospects of research. Modern problems of toxicology. 2011;4:11-27. (In Russ).]
  13. Шабанова Н.А., Попов В.В., Саркисов П.Д. Химия и технология нанодисперсных оксидов. — М.: ИКЦ Академкнига, 2007. — 309 с. [Shabanova N, Popov V, Sarkisov PD. Chemistry and technology of nanodispersed oxides. Moscow: Academkniga; 2007: 309 p.
  14. (In Russ).]
  15. Энциклопедия клинических лабораторных тестов / Под ред. Н. Тица. — М.: Лабинформ, 1997. — 960 c. [Encyclopedia of clinical laboratory tests. Ed by N. Tietz. Moscow: Labinform; 1997. 960 р. (In Russ).]
  16. Albanese A, Tang PS, Chan WC. The effect of nanoparticle size, shape, and surface chemistry on biological systems. Annu Rev Biomed Eng. 2012;14:1-16. doi: 10.1146/annurev-bioeng-071811-150124.
  17. A review of the scientific literature on the safety of nanoparticulate titanium dioxide or zinc oxide in sunscreens. Australian government/OTC Medicines Section/Therapeutic Goods Administration. 2009. 32 p. www.tga.gov.au.
  18. Bermudez E, Mangum JB, Asgharian B, et. аl. Long-term pulmonary responses of three laboratory rodent species to subchronic inhalation of pigmentary titanium dioxide. Toxicol Sci. 2002;70(1):86-97.
  19. Brayner R. The toxicological impact of nanoparticles. Nano Today. 2008;3(1-2):48-55. doi: 10.1016/S1748-0132(08)70015-X.
  20. Friends of the Earth, Nanomaterials, Sunscreens and Cosmetics: Small Ingredients, Big Risks/ Soil Association first organisation in the world to ban nanoparticles - potentially toxic beauty products that get right under your skin. Soil Association Press Release. 2008.
  21. Gurr JR, Wang AS, Chen CH, Jan KY. Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells. Toxicology. 2005;213(1-2):66-73.
  22. Hassellöv M, Readman JW, Ranville JF, Tiede K. Nanoparticle Analysis and Characterization Methodologies in Environmental Risk Assessment of Engineered Nanoparticles. Ecotoxicology.2008;17(5):344-361. doi: org/10.1007/s10646-008-0225-x.
  23. Hoet PH, Bruske-Hohlfeld I, Salata OV. Nanoparticles — known and unknown health risks. J Nanobiotechnology. 2004;2(1):12.
  24. Jeng HA, Swanson J. Toxicity of metal oxide nanoparticles in mammalian cells. J of Environmental Science and Health. Part A. 2006;41(12):2699-2711.
  25. Jiang J, Oberdrster G, Elder A, et al. Does nanoparticle activity depend upon size and crystal phase? Nanotoxicology. 2008;2(1):33-42.
  26. Jonaitis TS, Card JW, Magnuson B. Concerns regarding nano-sized titanium dioxide dermal penetration and toxicity study. Toxicology Letters. 2010;192(2):268-269. doi: 10.1016/j.toxlet.2009.10.007.
  27. Kahru A, Dubourguier HC, Blinova I, et al. Biotests and Biosensors for Ecotoxicology of Metal Oxide Nanoparticles: A Minireview. Sensors. 2008;8:5153-5170. doi: 10.3390/s8085153.
  28. Lewinski N, Colvin V, Drezek R. Cytotoxicity of Nanoparticles. Small-journal. 2008;4(1):26-49. doi: 10.1002/smll.200700595.
  29. Oberdörster G, Elder A, Rinderknecht A. Nanoparticles and the Brain: Cause for Concern? J Nanosci Nanotechnol. 2009;9(8):4996-5007. doi: 10.1166/jnn.2009.gr02.
  30. Oberdörster G, Maynard A, Donaldson K, et. аl. Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy. Part. and Fibre Toxicology. 2005;2:8. doi: 10.1186/1743-8977-2-8.
  31. Oberdörster G, Oberdörster E, Oberdörster J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect. 2005;113(7):823-839.
  32. Oberdörster G. Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology. J internal medic. 2010;267(1):89-105.
  33. Ostiguy C, Soucy B, Lapointe G, et al. Health Effects of Nanoparticles-Second Edition, Studies and Research Projects. Report R-589. Montréal, IRSST. 2008.
  34. р.
  35. Panyala N, Pena-Mendez E, Havel J. Silver or silver nanoparticles: a hazardous threat to the environment and human health? J Appl Biomed. 2008;6:117-129.
  36. Park B, Donaldson K, Duffin R, et al. Hazard and risk assessment of a nanoparticulate cerium oxide-based diesel fuel additive — a case study. Inhalation Toxicology: International Forum for Respiratory Research. 2008; 20(6):547-566. doi: 10.1080/08958370801915309.
  37. Patil S, Reshetnikov S, Haldar MK, et al. Surface-derivatized nanoceria with human carbonic anhydrase II inhibitors and fluorophores: a potential drug delivery device. J Phys Chem. 2007;111:8437-8442.
  38. Sahoo SK, Parveen S, Panda JJ. The present and future of nanotechnologyin human health care. Nanomedicine: Nanotechnolog, Biology and Medicine. 2007;3(1):20-31.
  39. Shang L, Nienhaus K, Nienhaus G. Engineered nanoparticles interacting with cells: size matters. J Nanobiotechnology. 2014;12(5):1-11. doi: 10.1186/1477-3155-12-5.
  40. Wang J, Sanderson B, Wang H. Cyto- and genotoxicity of ultrafine TiO2 particles in cultured human lymphoblastoid cells. Mutat Res. 2007;628(2):99-106.
  41. Withdrawal assessment report for Sinerm. Report EMEA. CHMP London. 11527. 2008.
  42. Yoo JW, Irvine DJ, Discher DE, Mitragotri S. Bio-inspired, bioengineered and biomimetic drug delivery carriers. Nat Rev Drug Discov. 2011;10(7):521-535. doi: 10.1038/nrd3499.
  43. http://abercade.ru/research/analysis.
  44. http://www.edobavkam.net/e171.html.
  45. http://www.tallevast.info/pdfs/102006tallevastinfoWEB.pdf.
  46. http://www.ukfoodguide.net/e171.htm.

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Copyright (c) 2016 Zeinalov O.А., Kombarova S.P., Bagrov D.V., Petrosyan M.A., Tolibova G.H., Feofanov A.V., Shaitan K.V.

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