Prospects for the pharmacological validation of the use of platelets as a “peripheral model” of neurons
- Authors: Urakov A.L.1, Nikitina I.L.2, Klen E.E.2, Wang Y.3, Samorodov A.V.2
-
Affiliations:
- Izhevsk State Medical University
- Bashkir State Medical University
- Hangzhou Normal University
- Issue: Vol 21, No 4 (2023)
- Pages: 307-317
- Section: Reviews
- URL: https://journals.eco-vector.com/RCF/article/view/568907
- DOI: https://doi.org/10.17816/RCF568907
- ID: 568907
Cite item
Abstract
Depressive disorders often occur in patients with cardiovascular pathologies and are a predictor of the development of thrombotic events, such as myocardial infarction, acute ischemic cerebrovascular accident, and pulmonary embolism. These are believed to be caused by the structural and biochemical relationship between platelets and brain neurons, which allows us to consider platelets as a marker of central nervous system (CNS) pathologies. This review aimed to assess the relationship between the hemostasis system and the development of depressive disorders using platelets as a “peripheral model” of neurons and evaluate the effectiveness of drugs for the treatment of depression. The study was conducted in accordance with the recommendations of Preferred Reporting Items for Systematic Reviews and Meta-Analyses. A systematic literature search was conducted using PubMed, Cochrane, and CINAHL databases from 2018 to 2023, according to the following keywords: “hemostasis,” “acute cerebrovascular accident,” “depression,” “depressive disorders,” “platelets,” “cardiovascular diseases.” The data obtained indicate both a clinical link between depressive disorders and vascular events and the commonality of platelets and CNS cells because of the commonality of the following proteins: transporters and receptors of serotonin or 5-hydroxytryptamine, amyloid precursor protein, and brain neurotrophic factor, which were previously considered specific neural proteins. In addition, a relationship exists between hemostasis dynamics and drug therapy for depression. In this review, changes in hemostasis in terms of platelet activation in patients with depression and vascular disease were critically analyzed. The literature presents diverse mechanisms of platelet induction, which require further study. A rational study of the pathways of platelet activation in patients with depressive disorders will provide a comprehensive understanding of the molecular mechanisms underlying the relationship between hemostasis and depression in various vascular pathologies. Platelet activation in patients with depression and the dynamics of changes in hemostasis parameters during the treatment of depressive disorders allow us to consider hemostasis as a peripheral marker of the CNS and pharmacotherapy.
Full Text
About the authors
Aleksandr L. Urakov
Izhevsk State Medical University
Author for correspondence.
Email: urakoval@live.ru
ORCID iD: 0000-0002-9829-9463
SPIN-code: 1613-9660
MD, Dr. Sci. (Medicine)
Russian Federation, IzhevskIrina L. Nikitina
Bashkir State Medical University
Email: irennixleo@gmail.com
ORCID iD: 0000-0002-6283-5762
SPIN-code: 4044-3774
MD, Dr. Sci. (Medicine)
Russian Federation, UfaElena E. Klen
Bashkir State Medical University
Email: klen_elena@yahoo.com
ORCID iD: 0000-0001-7538-6030
SPIN-code: 7520-9021
MD, Dr. Sci. (Pharmacy), Professor
Russian Federation, UfaYi Wang
Hangzhou Normal University
Email: yi.wang1122@wmu.edu.cn
ORCID iD: 0000-0001-9048-0092
Scopus Author ID: 55969091300
MD, Professor
China, HangzhouAleksandr V. Samorodov
Bashkir State Medical University
Email: avsamorodov@gmail.com
ORCID iD: 0000-0001-9302-499X
SPIN-code: 2396-1934
MD, Dr. Sci. (Med.), Assistant Professor
Russian Federation, UfaReferences
- Sama J, Vaidya D, Mukherjee M, Williams M. Effects of clinical depression on left ventricular dysfunction in patients with acute coronary syndrome. J Thromb Thrombolysis. 2021;51(3):693–700. doi: 10.1007/s11239-020-02268-4
- Amadio P, Zarà M, Sandrini L, et al. Depression and cardiovascular disease: the viewpoint of platelet. Int J Mol Sci. 2020;21(20):7560. doi: 10.3390/ijms21207560
- O’Donnell MJ, Xavier D, Liu L, et al. Risk factors for ischemic and intracerebral hemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study. Lancet. 2019;376(9735):112–23. doi: 10.1016/S0140-6736(10)60834-3
- Bucciarelli V, Caterino AL, Bianco F, et al. Depression and cardiovascular disease: The deep blue sea of women’s heart. Trends in Cardiovasc Med. 2020;30(3):170–176. doi: 10.1016/j.tcm.2019.05.001
- Zerriaa O, Moula O, Ben Saadi S, et al. Benefits of antidepressant treatment after a stroke. Eur Psychiatry. 2017;41(S1):S315. doi: 10.1016/j.eurpsy.2017.02.225
- Van Der Kooy K, Van Hout H, Marwijk H, et al. Depression and the risk for cardiovascular diseases: Systematic review and meta-analysis. Int J Geriatr Psychiatry. 2007;22(7):613–626. doi: 10.1002/gps.1723
- Batelaan NM, Seldenrijk A, Bot M, et al. Anxiety and new onset of cardiovascular disease: Critical review and meta-analysis. Br J Psychiatry. 2016;208(3):223–231. doi: 10.1192/bjp.bp.114.156554
- Carney RM, Freedland KE. Depression and coronary heart disease. Nat Rev Cardiol. 2016;14(3):145–155. doi: 10.1038/nrcardio.2016.181
- Gan Y, Gong Y, Tong X, et al. Depression and the risk of coronary heart disease: A meta-analysis of prospective cohort studies. BMC Psychiatry. 2014;14:371. doi: 10.1186/s12888-014-0371-z
- Lichtman JH, Froelicher ES, Blumenthal JA, et al. Depression as a risk factor for poor prognosis among patients with acute coronary syndrome: systematic review and recommendations. Circulation. 2014;129(12):1350–1369. doi: 10.1161/CIR.0000000000000019
- Canobbio I. Blood platelets: Circulating mirrors of neurons? Res Pract Thromb Haemost. 2019;3:564–565. doi: 10.1002/rth2.12254
- Canobbio I, Guidetti GF, Torti M. Platelets in neurological disorders. In: Platelets in Thrombotic and Non-Thrombotic Disorders: Pathophysiology, Pharmacology and Therapeutics: An Update. 2017. P. 1145. doi: 10.1007/978-3-319-47462-5
- Tseng WL, Chen TH, Huang CC, et al. Impaired thrombin generation in Reelin-deficient mice: A potential role of plasma Reelin in hemostasis. J Thromb Haemost. 2014;12(12):2054–2064. doi: 10.1111/jth.12736
- Canobbio I, Visconte C, Momi S, et al. Platelet amyloid precursor protein is a modulator of venous thromboembolism in mice. Blood. 2017;130(4):527–536. doi: 10.1182/blood-2017-01-764910
- Chacón-Fernández P, Säuberli K, Colzani M, et al. Brain-derived neurotrophic factor in megakaryocytes. J Biol Chem. 2016;291(19):9872–9881. doi: 10.1074/jbc.M116.720029
- Serpytis P, Navickas P, Lukaviciute L, et al. Gender-Based differences in anxiety and depression following acute myocardial infarction. Arq Bras Cardiol. 2018;111(5):676–683. doi: 10.5935/abc.20180161
- Malzberg B. Mortality among patients with involution melancholia. Am J Psychiatry. 1937;93(3):1231–1238. doi: 10.1176/ajp.93.5.1231
- Koenig HG, Murberg TA, Bru E, et al. Depression in hospitalized older patients with congestive heart failure. Gen Hosp Psychiatry. 1998;20(1):29–43. doi: 10.1016/S0163-8343(98)80001-7
- Gimeno D, Kivimäki M, Brunner EJ, et al. Associations of C-reactive protein and interleukin-6 with cognitive symptoms of depression: 12-year follow-up of the Whitehall II study. Psychol Med. 2009;39(3):413–423. doi: 10.1017/S0033291708003723
- Kalogeropoulos A, Georgiopoulou V, Psaty BM, et al. Inflammatory markers and incident heart failure risk in older adults. The Health ABC (Health, Aging, and Body Composition) study. 2010;55(19): 2129–2137. doi: 10.1016/j.jacc.2009.12.045
- Williams M.S., Ziegelstein R.C., McCann U.D., et al. Platelet serotonin signaling in patients with cardiovascular disease and comorbid depression. Psychosom Med. 2019;81(4):352–362. doi: 10.1097/PSY.0000000000000689
- Mommersteeg PM, Schoemaker RG, Naudé PJ, et al. Depression and markers of inflammation as predictors of all-cause mortality in heart failure. Brain Behav Immun. 2016;57:144–150. doi: 10.1016/j.bbi.2016.03.012
- Musselman DL, Aaron T, Amita KM, et al. Exaggerated platelet reactivity in major depression. Am J Psychiatry. 1996;153(10): 1313–1317. doi: 10.1176/ajp.153.10.1313
- Koudouovoh-Tripp P, Hüfner K, Egeter J, et al. Platelet activity: the impact of acute and chronic mental stress. J Neuroimmune Pharmacol. 2021;16(2):500–512. doi: 10.1007/s11481-020-09945-4
- Samad Z, Boyle S, Ersboll M, et al. Sex differences in platelet reactivity and cardiovascular and psychological response to mental stress in patients with stable ischemic heart disease: insights from the REMIT study. J Am Coll Cardiol. 2014;64(16):1669–1678. doi: 10.1016/j.jacc.2014.04.087
- Goubau C, Buyse GM, Van Geet C, Freson K. The contribution of platelet studies to the understanding of disease mechanisms in complex and monogenetic neurological disorders. Dev Med Child Neurol. 2014;56(8):724–731. doi: 10.1111/dmcn.12421
- Ponomarev ED. Fresh evidence for platelets as neuronal and innate immune cells: their role in the activation, differentiation, and deactivation of Th1, Th17, and tregs during tissue inflammation. Front Immunol. 2018;9:406. doi: 10.3389/fimmu.2018.00406
- Izzi B, Tirozzi A, Cerletti C, et al. Beyond haemostasis and thrombosis: platelets in depression and its co-morbidities. Int J Mol Sci. 2020;21(22):8817. doi: 10.3390/ijms21228817
- Canobbio I, Guidetti GF, Torti M. Platelets in neurological disorders. In: Platelets in Thrombotic and Non-Thrombotic Disorders. Springer International: Cham, Switzerland. 2017. P. 513–530. doi: 10.1007/978-3-319-47462-5_35
- Canobbio I, Guidetti GF, Oliviero B, et al. Amyloid beta-peptide-dependent activation of human platelets: Essential role for Ca2+ and ADP in aggregation and thrombus formation. Biochem J. 2014;462(3):513–523. doi: 10.1042/BJ20140307
- Yubero-Lahoz S, Robledo P, Farré M, de laTorre R. Platelet SERT as a peripheral biomarker of serotonergic neurotransmission in the central nervous system. Curr Med Chem. 2013;20(11):1382–1396. doi: 10.2174/0929867311320110003
- Holinstat M. Normal platelet function. Cancer Metastasis Rev. 2017;36(2):195–198. doi: 10.1007/s10555-017-9677-x
- Mercado CP, Kilic F. Molecular mechanisms of SERT in platelets: Regulation of plasma serotonin levels. Mol Interv. 2010;10(4):231–241. doi: 10.1124/mi.10.4.6
- Mammadova-Bach E, Mauler M, Braun A, Duerschmied D. Autocrine and paracrine regulatory functions of platelet serotonin. Platelets. 2018;29(6):541–548. doi: 10.1080/09537104.2018.1478072
- Zhuang X, Xu H, Fang Z, et al. Platelet serotonin and serotonin transporter as peripheral surrogates in depression and anxiety patients. Eur J Pharmacol. 2018;834:213–220. doi: 10.1016/j.ejphar.2018.07.033
- Kitazume S, Yoshihisa A, Yamaki T, et al. Soluble amyloid precursor protein 770 is released from inflamed endothelial cells and activated platelets: A novel biomarker for acute coronary syndrome. J Biol Chem. 2012;287(48):40817–40825. doi: 10.1074/jbc.M112.398578
- Stakos DA, Stamatelopoulos K, Bampatsias D, et al. The Alzheimer’s disease amyloid-beta hypothesis in cardiovascular aging and disease: JACC focus seminar. J Am Coll Cardiol. 2020;75(8): 952–967. doi: 10.1016/j.jacc.2019.12.033
- Jarre A, Gowert NS, Donner L, et al. Pre-activated blood platelets and a pro-thrombotic phenotype in APP23 mice modeling Alzheimer’s disease. Cell Signal. 2014;26(9):2040–2050. doi: 10.1016/j.cellsig.2014.05.019
- Visconte C, Canino J, Guidetti GF, et al. Amyloid precursor protein is required for in vitro platelet adhesion to amyloid peptides and potentiation of thrombus formation. Cell Signal. 2018;52:95–102. doi: 10.1016/j.cellsig.2018.08.017
- Mazinani N, Strilchuk AW, Baylis JR, et al. Bleeding is increased in amyloid precursor protein knockout mouse. Res Pract Thromb Haemost. 2020;4(5):823–828. doi: 10.1002/rth2.12375
- Ramos-Cejudo J, Johnson AD, Beiser A, et al. Platelet function is associated with dementia risk in the framingham heart study. J Am Heart Assoc. 2022;11(9):e023918. doi: 10.1161/JAHA.121.023918
- Wang Q, Shi Y, Qi X, et al. Platelet-derived amyloid-β protein precursor as a biomarker of Alzheimer’s disease. J Alzheimers Dis. 2022;88(2):589–599. doi: 10.3233/JAD-220122
- Shi Y, Gu L, Wang Q, Gao L, et al. Platelet amyloid-β protein precursor (AβPP) ratio and phosphorylated tau as promising indicators for early Alzheimer’s disease. J Gerontol A Biol Sci Med Sci. 2020;75(4):664–670. doi: 10.1093/gerona/glz005
- Fu J, Lai X, Huang Y, et al. Meta-analysis and systematic review of peripheral platelet-associated biomarkers to explore the pathophysiology of Alzheimer’s disease. BMC Neurol. 2023;23(1):66. doi: 10.1186/s12883-023-03099-5
- Zagrebelsky M, Korte M. Form follows function: BDNF and its involvement in sculpting the function and structure of synapses. Neuropharmacology. 2014;76:628–638. doi: 10.1016/j.neuropharm.2013.05.029
- Naegelin Y, Dingsdale H, Säuberli K, et al. Measuring and validating the levels of brain-derived neurotrophic factor in human serum. eNeuro. 2018;5(2):ENEURO.0419-17.201
- Amadio P, Zarà M, Sandrini L, et al. Depression and cardiovascular disease: the viewpoint of platelets. Int J Mol Sci. 2020;21(20):7560. doi: 10.3390/ijms21207560
- Chacon-Fernandez P, Sauberli K, Colzani M, et al. Brain-derived neurotrophic factor in megakaryocytes. J Biol Chem. 2016;291(19):9872–9881. doi: 10.1074/jbc.M116.720029
- Serra-Millas M, Lopez-Vilchez I, Navarro V, et al. Changes in plasma and platelet BDNF levels induced by S-citalopram in major depression. Psychopharmacology (Berl). 2011;216(1):1–8. doi: 10.1007/s00213-011-2180-0
- Betti L, Palego L, Unti E, et al. Brain-derived neurotrophic factor (BDNF) and serotonin transporter (sert) in platelets of patients with mild huntington’s disease: relationships with social cognition symptoms. Arch Ital Biol. 2018;156(1–2):27–39. doi: 10.12871/00039829201813
- Falaschi V, Palego L, Marazziti D, et al. Variation of circulating brain-derived neurotrophic factor (BDNF) in depression: relationships with inflammatory indices, metabolic status and patients’ clinical features. Life (Basel). 2023;13(7):1555. doi: 10.3390/life13071555
- Tschorn M, Kuhlmann SL, Rieckmann N, et al. Brain-derived neurotrophic factor, depressive symptoms and somatic comorbidity in patients with coronary heart disease. Acta Neuropsychiatr. 2021;33(1):22–30. doi: 10.1017/neu.2020.31
- Duman RS, Monteggia LM. A neurotrophic model for stress-related mood disorders. Biol Psychiatry. 2006;59(12):1116–1127. doi: 10.1016/j.biopsych.2006.02.013
- Liu CY, Jiang XX, Zhu YH, Wei DN. Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine produces antidepressant effects in rats: Role of brain-derived neurotrophic factor. Neuroscience. 2012;223:219–224. doi: 10.1016/j.neuroscience.2012.08.010
- Karege F, Bondolfi G, Gervasoni N, et al. Low brain-derived neurotrophic factor (BDNF) levels in serum of depressed patients probably results from lowered platelet BDNF release unrelated to platelet reactivity. Biol Psychiatry. 2005;57(9):1068–1072. doi: 10.1016/j.biopsych.2005.01.008
- Saito S, Watanabe K, Hashimoto E, Saito T. Low serum BDNF and food intake regulation: A possible new explanation of the pathophysiology of eating disorders. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33(2):312–316. doi: 10.1016/j.pnpbp.2008.12.009
- Canan F, Dikici S, Kutlucan A, et al. Association of mean platelet volume with DSM-IV major depression in a large community-based population: The MELEN study. J Psychiatr Res. 2012;46(3):298–302. doi: 10.1016/j.jpsychires.2011.11.016
- Cai L, Xu L, Wei L, Chen W. Relationship of mean platelet volume to MDD: a retrospective study. Shanghai Arch Psychiatry. 2017;29(1):21–29. doi: 10.11919/j.issn.1002-0829.216082
- Bondade S, Supriya Seema HS, Shivakumar BK. Mean platelet volume in depression and anxiety disorder — a hospital based case-control study. Int Neuropsychiatr Dis J. 2018;11(4):1–8. doi: 10.9734/INDJ/2018/42988
- Ataoglu A, Canan F. Mean platelet volume in patients with major depression: Effect of escitalopram treatment. J Clin Psychopharmacol. 2009;29(4):368–371. doi: 10.1097/JCP.0b013e3181abdfd7
- Aleksovski B, Neceva V, Vujovic V, et al. SSRI-reduced platelet reactivity in non-responding patients with life-long Recurrent Depressive Disorder: Detection and involved mechanisms. Thromb Res. 2018;165:24–32. doi: 10.1016/j.thromres.2018.03.006
- Gialluisi A, Izzi B, Di Castelnuovo A, et al. Revisiting the link between platelets and depression through genetic epidemiology: New insights from platelet distribution width. Haematologica. 2019;105(5): e246–e248. doi: 10.3324/haematol.2019.222513
- Gialluisi A, Bonaccio M, Di Castelnuovo A, et al. Lifestyle and biological factors influence the relationship between mental health and low-grade inflammation. Brain Behav Immun. 2020;85:4–13. doi: 10.1016/j.bbi.2019.04.041
- Wang JM, Yang KD, Wu SY, et al. Platelet parameters, c-reactive protein, and depression: an association study. Int J Gen Med. 2022;15:243–251. doi: 10.2147/IJGM.S338558