The human brain is working in the system of dual coding: a hypothesis



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Abstract

How the human brain is working is up to now unclear. Using singular neuron as an object, and pharmacological agents as a tool the neuron activity in general in the mammalian CNS has been described. The basis of all investigations was the study of dimmer (heteromer) structures associated with G-coupled receptor proteins on the surfaces of neuron membranes isolated from the own usual circle. We can organize the recombinant movement by means of physiological concentrations of pharmacological reagents if these processes were lasting in the network neurons native brain. That is, the ideal conditions for the processes generation in the neural impulse were reconstructed.

About the authors

Anna Aleksandrovna Bukinich

Institute of Experimental Medicine, NWB RAMS

Email: abukinich@yahoo.com
PhD (Biochemistry), researcher, Anichkov Dept. of NeuroPharmacology

Petr Dmitriyevich Shabanov

Institute of Experimental Medicine, NWB RAMS

Email: pdshabanov@mail.ru
Dr. Med. Sci. (Pharmacology), Professor and Head, Anichkov Dept. of NeuroPharmacology

References

  1. Alexander S. P. H., Mathie A., Peter J. A. Guide to receptors and channels // Brit. J. Pharmacol. — 2006. — Vol. 147, N 3. — P. S32–36.
  2. Barreiro-Iglesias A., Villar-Cerviño V., Anadón R. et al. Descending brain-spinal cord projections in a primitive vertebrate, the lamprey: cerebrospinal fluid-contacting and dopaminergic neurons // J. Comp. Neurol. — 2008. — Vol. 511, N 6. — P. 711–723.
  3. Casadó V., Cortés A., Ciruela F. et al. Old and new ways to calculate the affinity of agonists and antagonists interacting with G-protein-coupled monomeric and dimeric receptors: the receptor-dimer cooperativity index // Pharmacol. Ther. — 2007. — Vol. 116, N 3. — P. 343–354.
  4. Casadó V., Ferrada C., Bonaventura J. at al. Useful pharmacological parameters for G-protein-coupled receptor homodimers obtained from competition experiments. Agonist-antagonist binding modulation // Biochem. Pharmacol. — 2009. — Vol. 78, N 12. — P. 1456–1463.
  5. Franco R., Casado V., Cortes A. at al. G-protein-coupled receptor heteromers: function and ligand pharmacology // Brit. J. Pharmacol. — 2008. — Vol. 153. — P. S90–S98.
  6. Seeman P. The Patent Description and Claims data below is from USPTO Patent Application 20080181848. Method to detect dopamine receptors in the functional d2 high state.
  7. Watson S., Arkinstall S. The G-protein linked receptor. Facts Book. — London: Academic Press, 1994. — P. 96–110.

Copyright (c) 2013 Bukinich A.A., Shabanov P.D.

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