Cholinergic modulation and neurochemical aspects of rat behavior after action of infraslow acoustic waves



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Abstract

The purpose of the paper was to study the role of cholinergic neurotransmitter system in neurochemical mechanisms of behavioral disorders in rats exposed to infraslow acoustic action (ISAA). The first group of rats was treated with a single exposure of ISAA 150 dBell. The second group (A) was treated with atropine 1 h before testing. The thrird group (ISAA + A) was pretreated with atropine 10 mg/kg 1 h prior to ISAA. The central functions were assessed in open field with preliminary typing of rats and by means of HPLC biochemical measure of dopamine, norepinephrine and serotonin and their turnover in hypothalamus and hippocampus. ISAA decreased locomotor, explorative and investigative behavior in open field, passive forms of behavior being increased. Atropine reduced emotional signs of behavior and recovered locomotor activity in rats. In 24 h after ISAA the investigative, explorative and locomotor activity of rats was recovered up to background level. ISAA decreased norepinephrine level, did not change serotonin concentration and increased dopamine level in hypothalamus. Pretreatment of atropine recovered dopamine level in hypothalamus but not in hippocampus. The mechanisms of cholinergic effects on monoamine turnover in the brain and emotional behavior are discussed.

About the authors

Ol'ga Vladimirovna Torkunova

Institute of Experimental Medicine

Email: abukinich@yahoo.com
Fellow, Dept. of NeuroPharmacology

Alekber Azizovich Bayramov

Institute of Experimental Medicine

Email: alekber@mail.ru
Dr. Med. Sci. (Pharmacology), senior researcher, Dept. of NeuroPharmacology

Petr Dmitriyevich Shabanov

Kirov Military Medical Academy

Email: pdshabanov@mail.ru
Doct. of Med. Sci. (Pharmacology), Professor and Head, Dept. of Pharmacology

References

  1. Минасян С. М. Интегративные структуры мозга при вибрации. - Ереван, 1990. - 272 с.
  2. Свидовый В. И. Инфразвук как фактор окружающей и производственной среды. СПб., 2002. - 140 с.
  3. Свидовый В. И. Сочетанное воздействие шума и инфразвука на организм, проблемы гигиенического нормирования и профілактики: Автореф. дис… д-ра мед. наук, 1994.
  4. Алексеев С. В., Мозжухина Н. А. К вопросу о механизмах действия инфразвука на организм человека и животных (обзор литературы) // Гигиена труда и проф. забол. - 1983. - № 9. - С. 35-37.
  5. Суворов Г. А. Фармакологическая регуляция жизнедеятельности организма через холинергические системы. Тез. докл. к конф. - Л., 1970. - С. 18-23.
  6. Зинкин В. Н., Богомолов А. В., Драган С. П., Ахметзянов И. М. Кумулятивные медико-экологические эффекты сочетанного действия шума и инфразвука // Экология и промышленность России. - 2012. - № 3. - С. 46-49.
  7. Байрамов А. А., Шабанов П. Д., Юкина Г. Ю. Влияние пренатального шумового стресса на содержание дофамина и серотонина в головном мозге 2,5-недельных плодов крыс // Обз. по клин. фармакол. и лек. терапии. - 2010. - Т. 8, № 1. - С. 57-58.
  8. Байрамов А. А., Жарова Л. Т., Полетаева А. О., Прошин С. Н., Изменение врожденного поведения в «открытом поле» у самцов крыс с пренатально модифицированной активностью холинергической системы//Психофармакол. и биол. наркология. - 2008. - Т. 8, № 1-2.
  9. Шабанов П. Д. Психофармакология. СПб.: Элби-СПб, 2008. - 416 с.
  10. De’Souza E. B., Van Loon G. R. Brain serotonin and catecholamine responses to repeated stress in rats // Brain Res. - 1986. - Vol. 367. - P. 77-86.
  11. Anisman H. Neurochemical changes elicited by stress: behavioral correlates // Psychopharmacology of aversively motivated behavior/Ed. by H. Anisman, G. Bignami. New York: Plenum press, 1978. - P. 119-171.
  12. Bliss E. L. Effects of behavioral manipulations upon brain serotonin and dopamine // Serotonin and behavior/Ed. by J. D. Barchas, E. Usdin. New York: Academic press, 1973. - P. 315-324.
  13. Goldstein M., Sauter A., Ueta K., Fuxe K. Effect of stress on central catecholamine levels // Catecholamines and stress: Recent advances/E. Usdin, R. Kvetnansky, I. J. Kopin. New York: Elsevier/North-Holland, 1980. - P. 47-52.
  14. Roth K. A., Mefford I. M., Barchas J. D. Epinephrine, norepinephrine, dopamine and serotonin: differential effects of acute and chronic stress on regional brain amines // Brain Res. - 1982. - Vol. 239. - P. 417-424.
  15. Corrodi H., Fuxe K., Lidbrink P., Olson L. Minor trasquilizers, stress, and catecholamine neurons // Brain Res. - 1971. - Vol. 29. - P. 1-16.
  16. Lidbrink P., Corrodi H., Fuxe K., Olson L. Barbiturates and meprobamate: decrease in catecholamine turnover on central dopamine and noradrenaline neuronal systems and the influence of immobilization stress // Brain Res. - 1972. - Vol. 45. - P. 507-524.
  17. Thierry A. M., Javoy F., Glowinski J., Kety S. S. Effects of stress on the metabolism of norepinephrine, dopamine and serotonin in the central nervous system of the rat. I. Modifications of norepinephrine turnover // J. Pharmacol. Exp. Ther. - 1968. - Vol. 163. - P. 163-171.
  18. Acosta G. B., Otero Losada M. E., Rubio M. C. Area dependent changes in GABAergic function after acute and chronic cold stress // Neurosci. Lett. 1993. - Vol. 154. - P. 175-178.
  19. Otero Losada M. E. Acute stress and GABAergic function in the rat brain // Brit. J. Pharmacol. - 1989. - Vol. 96. - P. 507-512.
  20. Gilad G. M., Mohan B. D., Finkelstein Y., Koffler B., Gilad V. H. Stress-induced activation of the hippocampal cholinergic system and the pituitary-adrenocortical axis // Brain Res. - 1985. - Vol. 347. - P. 404-408.
  21. Carlson J. N., Fitzgerald L. W., Keller R. W., Glick S. D. Lateralized changes in prefrontal cortical dopamine activity induced by controllable and uncontrollable stress in the rat // Brain Res. - 1993. - Vol. 630. - P. 178-187.
  22. Deutch A. Y., Roth R. H. The determinants of stress-induced activation of the prefrontal cortical dopamine system // Prog. Brain Res. - 1990. - Vol. 85. - P. 367-402.
  23. Dunn A. J. Changes in plasma and brain tryptophan, and brain serotonin and 5-hydroxyindoleacetic acid after foot shock stress // Life Sci. - 1988. - Vol. 42. - P. 1847-1853.
  24. Anisman H., Kokkinidis I., Sklar L. S. Contribution of neurochemical change to stress-induced behavioral deficits // Theory in psychopharmacology / Ed. by S. J. Cooper. London: Academic press, 1981. - P. 65-102.
  25. Miura H., Naoi M., Nakamura D., Ohta T., Nagatsu T. Changes in monoamine levels in mouse brain elicited by forced swimming stress and the protective effect of a new monoamine oxidase inhibitor // J. Neural Trans. - 1993. - Vol. 94. - P. 175-189.
  26. Weiss J. M., Goodman P. A., Losito B. G., Corrigan S., Charry J. M., Bailey W. H. Behavioral depression produced by an uncontrollable stressors: relationships to norepinephrine, dopamine and serotonin levels in various regions in the rat brain // Brain Res. Rev. - 1981. - Vol. 3. - P. 43-49.
  27. Nakamura S. Axonal sprouting of noradrenergic locus coeruleus neurons following repeated stress and antidepressant treatment // Prog. Brain Res. - 1991. - Vol. 88. - P. 587-598.
  28. Sunanda B. S. Shankaranarayana Rao, Raju T. R. Restraint Stress-Induced Alterations in the Levels of Biogenic Amines, Amino Acids, and AChE Activity in the Hippocampus // Neurochem. Res. - 2000. - Vol. 25, N 12. - P. 1547-1552.

Copyright (c) 2015 Torkunova O.V., Bayramov A.A., Shabanov P.D.

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