Influence of antihypoxants on the development of acute phormalin-induced edema
- Authors: Novikov V.E.1, Pozhilova E.V.1, Ilyukhin S.A.1
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Affiliations:
- Smolensk State Medical Academy
- Issue: Vol 13, No 1 (2015)
- Pages: 41-44
- Section: Articles
- URL: https://journals.eco-vector.com/RCF/article/view/731
- DOI: https://doi.org/10.17816/RCF13141-44
Cite item
Full Text
Abstract
In the experiment in a model of acute formalin-induced inflammation of rat paw, the changes of size of the affected limbs (paw edema) and parameters of leukogram were registered. The anti-inflammatory effect of antihypoxants (amtizol, hesperidin, hypoxen, metaprot) was investigated. It has been shown that hypoxen 50 mg/kg have weak anti-inflammatory activity, but potentiate the effect of nonsteroid anti-inflammatory drugs. At simultaneous enteral administration of hypoxen with acetylsalicylic acid or diclofenac, evident anti-inflammatory effect was marked, that was manifested by significant reduction in registered inflammation symptoms.
Keywords
About the authors
Vasiliy Egorovich Novikov
Smolensk State Medical Academy
Email: nau@sgma.info
MD, professor, Head of the Department of Pharmacology
Elena Vasil'yevna Pozhilova
Smolensk State Medical Academy
Email: nau@sgma.info
Postgraduate Fellow, Dept. of Normal Physiology
Sergey Alekseevich Ilyukhin
Smolensk State Medical Academy
Email: nau@sgma.info
Cand. Biol. Sci., Postgraduate Fellow, Dep. of Pharmacology
References
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