Expediency of application of animals with the spontaneous hypertensia for modelling of the metabolic syndrome

Abstract

When used within 11 weeks of diet “cafeteria diet” in spontaneously-hypertensive animals could lead to an increase in systolic blood pressure by 9%, sustained hyperglycemia, increased blood concentrations of triglycerides and cholesterol, as well as an increase in the relative content of visceral fat. In normotensive animals line Wistar-Kyoto prolonged use of “cafeteria diet” was accompanied only by an increase in blood glucose, cholesterol and triglycerides. Thus, the spontaneously hypertensive animals, the application of high-calorie diet demonstrated by three criteria pathogenesis of the metabolic syndrome: hyperglycemia, hypertension and visceral obesity, which allows you to use the model for the study of drugs aimed at treatment of metabolic syndrome.

About the authors

Maria Alexandrovna Kovaleva

Mechnikov North-West State Medical University

Email: makarov@ipharm.sp.ru
junior researcher

Marina Nikolayevna Makarova

Mechnikov North-West State Medical University

Email: mmn2410@yandex.ru
PhD

A. I. Selezneva

Saint-Petersburg institute of pharmacy

Email: alexs79@mail.ru

Valeriy Gennadyevich Makarov

Mechnikov North-West State Medical University

Email: makarov@ipharm.sp.ru
PhD, ScD, professor.

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Copyright (c) 2012 Kovaleva M.A., Makarova M.N., Selezneva A.I., Makarov V.G.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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