Preventive and therapeutic strategies of pharmaco-correction gastropathy induced by nonsteroidal anti-inflammatory drugs

Cover Page

Abstract


Today the problem of prevention and treatment of gastropathy associated with nonsteroidal anti-inflammatory drugs has not lost its relevance. In order to reduce the ulcerogenicity of non-steroidal anti-inflammatory drugs, it is classically accepted to supplement the therapy scheme with preparations of other pharmacological groups — antacids, alginates, M-cholinoblockers, gastrin receptor antagonists, H2-histamine blockers, proton pump inhibitors, synthetic analogues of prostaglandins or stimulators of their synthesis, reparants, gastroprotectors. Nowadays, it was suggested I was suggested the use of drugs which have pharmacological properties polyvector (vinboron, thiotriazoline et al.). Also, the scientists started of combined preparations “NSAIDs + drugs other pharmacological groups” — indotril (indomethacin + thiotriazoline) diklokor (diclofenac + quercetin) Artrotek (diclofenac sodium + misoprostol) dueksis (ibuprofen + famotidine) vimovo (naproxen + esomeprazole) aksorid (ketoprofen + omeprazole) tioaspekard (thiotriazoline + ACK) aspifat (ACK + sucralfate), Alka-Zelttser® (ACK + sodium bicarbonate), and others. The second direction is preventing and improving NSAID gastrotoxicity protrudes improving existing non-steroidal drugs – modification of gaseous molecules (NO, H2S, CO), amino acid derivatives, modulators “effector function” of afferent terminals n. vagus (amtolmetina guatsil) то pairing with nanoparticles biometals (Zn-ibuprofen, Zn-naproxen, Zn-indomethacin).


Feydor V. Hladkykh

Grigoriev Institute for medical Radiology, The National Academy of Medical Sciences of Ukraine

Author for correspondence.
Email: fedir.hladkykh@gmail.com
ORCID iD: 0000-0001-7924-4048
SPIN-code: 2126-1563

Ukraine, Kharkiv

  1. Балукова Е.В. НПВП-индуцированная гастропатия: от понимания механизмов развития к разработке стратегии профилактики и лечения // Российский медицинский журнал. – 2017. – № 10. – С. 697–702. [Balukova EV. NSAID-induced gastropathy: from an understanding of the mechanisms of development to the development of a strategy of prevention and treatment. Russian medical journal. 2017;(10):697-702. (In Russ.)]
  2. Булгаков С.А. Гексапептид даларгин в клинической гастроэнтерологии: 30-летний опыт использования препарата // Российский журнал гастроэнтерологии, гепатологии, колопроктологии. – 2016. – № 3. – С. 103–112. [Bulgakov SA. Hexapeptide dalargin in clinical gastroenterology: 30 years of experience using the drug. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2016;(3):103-112. (In Russ.)]
  3. Гладких Ф.В. Характеристика механизмов антиульцерогенного действия агонистов ванилоидных рецепторов (TRPV1) на модели гастропатии, индуцированной ацетилсалициловой кислотой // Фармация и фармакология. – 2017. – Т. 5. – № 3. – С. 283–301. [Hladkykh FV. The characteristics of the mechanisms of anti-ulcerogenic action of vanilloid receptor agonists (TRPV1) on the model of gastropathy induced by acetylsalicylic acid. Pharmacy and pharmacology. 2017;5(3):283-301. (In Russ.)]. doi: 10.19163/2307-9266-2017-5-3-283-301.
  4. Гладких Ф.В., Степанюк Н.Г. Вінборон: перший український гастропротектор — агоніст ванілоїдних рецепторів (TRPV1) // Фармакологія та лікарська токсикологія. – 2016. – 4–5(50). – С. 20–29. [Hladkykh FV, Stepanyuk NH. Vinboron: The first Ukrainian gastroprotector — the vanilloid receptor agonist (TRPV1). Pharmacology and drug toxicology. 2016;4-5(50):20-29. (In Ukr.)]
  5. Гладких Ф.В., Степанюк Н.Г. Сучасні шляхи послаблення ульцерогенності нестероїдних протизапальних засобів: досягнення, невирішені питання та шляхи оптимізації // Запорожский медицинский журнал. – 2014. – № 2 (83). – С. 82–86. [Hladkykh FV, Stepanyuk NH. New approaches to reduce ulcerogenity of nonsteroidal anti-infl ammatory drugs: achievements, unsolved issues and ways to optimize. Zaporozhye Medical Journal. 2014;2(83):82-86. (In Ukr.)]. doi: 10.14739/2310-1210.2014.2.25437.
  6. Голованова Е.В. Защита слизистой оболочки ЖКТ от повреждающего действия нестероидных противовоспалительных препаратов // Клиническая геронтология. – 2017. – № 1–2. – С. 47–51. [Golovanova EV. Protection of the gastrointestinal mucosa from the damaging effects of non-steroidal anti-inflammatory drugs. Clinical gerontology. 2017;(1-2):47-51. (In Russ.)]
  7. Ефимов А.Л., Сигуа Б.В., Филаретова Л.П. Острые язвы и эрозии желудочно-кишечного тракта, индуцированные нестероидными противовоспалительными препаратами: этиология, патогенез, лечебная тактика // Вестник Российской военно-медицинской академии. – 2017. – № 1 (57). – С. 198–204. [Efimov AL, Sigua BV, Filaretova LP. Acute ulcers and erosions of the gastrointestinal tract, induced by non-steroidal anti-inflammatory drugs: etiology, pathogenesis, therapeutic tactics. Bulletin of the Russian Military Medical Academy. 2017;1(57):198-204. (In Russ.)]
  8. Каратеев А.Е. Шесть ножей в спину ингибиторам протонной помпы // Научно-практическая ревматология. – 2013. – № 51 (3). – С. 332–340. [Karateev AE. Six knives in the back of the inhibitors of the proton pump. Scientific and practical rheumatology. 2013;51(3):332-340. (In Russ.)]. doi: 10.14412/1995-4484-2013-1509.
  9. Каратеев А.Е., Насонов Е.Л., Раденска-Лоповок С.Г. Эффективность висмута трикалия дицитрата («Де-нола») при гастропатиях, индуцированных нестероидными противовоспалительными препаратами: открытое контролируемое 4-недельное исследование // Сучасна гастроентерологія. – 2005. – № 77 (2). – С. 46–49. [Karateev AE, Nasonov EL, Radenska-Lopovok SG. The effectiveness of bismuth tricalium dicitrate (“De-nol”) in gastropathies induced by non-steroidal anti-inflammatory drugs: an open controlled 4-week study. Gastroenterology is common. 2005;77(2):46-49. (In Russ.)]
  10. Маев И.В., Андреев Д.Н., Дичева Д.Т. Гастропатии, индуцированные нестероидными противовоспалительными препаратами: патогенетически обоснованные подходы к профилактике и терапии // Фарматека. – 2016. – № 2. – С. 49–54. [Maev IV, Andreev DN, Dicheva DT. Gastropathy, induced by non-steroidal anti-inflammatory drugs: pathogenetically grounded approaches to prevention and therapy. Pharmatec. 2016;(2):49-54. (In Russ.)]
  11. Плотникова Е.Ю. Актуальность антацидов и альгинатов в лечении заболеваний органов пищеварения // Лечащий врач. – 2015. – № 2. – С. 58–64. [Plotnikova EYu. The relevance of antacids and alginates in the treatment of diseases of the digestive system. Therapist. 2015;(2):58-64. (In Russ.)]
  12. Подплетняя Е.А., Кучеренко Л.И., Мамчур В.И., и др. Биохимические аспекты синергизма компонентов препарата «Индотрил» // Запорожский медицинский журнал. – 2008. – № 4. – С. 139–141. [Podpletnyaya EA, Kucherenko LI, Mamchur VI, et al. Biochemical aspects of synergism of the components of the preparation “Indotril”. Zaporozhye Medical Journal. 2008;(4):139-141. (In Russ.)]
  13. Скоромец А.А., Баранцевич Е.Р., Амелин А.В., и др. Протокол совета экспертов Северо-Западного федерального округа Российской Федерации по вопросам рационального подхода в лечении болевого синдрома и воспаления в неврологии // Медицинский совет. – 2015. – № 7. – С. 51–52. [Amelin AV, Afanasiev VV, Starikov PV, et al. Protocol of the Council of Experts of the North-West Federal District of the Russian Federation on the rational approach in the treatment of pain syndrome and inflammation in neurology. Medical advice. 2015;(7):51-052. (In Russ.)]. doi: 10.21518/2079-701X-2015-7-51-53.
  14. Сулаева О.Н., Уоллес Дж.Л. Новая стратегия гастроинтестинальной протекции с использованием газообразных медиаторов // Российский журнал гастроэнтерологии, гепатологии, колопроктологии. – 2016. – № 3. – С. 17–23. [Sulaeva ON, Wallace JL. A new strategy of gastrointestinal protection with the use of gaseous mediators. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2016;(3):17-23. (In Russ.)]
  15. Таран И.В. Модуляция гастротоксичности диклофенака натрия в условиях разного уровня насыщенности организма гидроген сульфидом (экспериментальное исследование): Дис. … канд. мед. наук: спец. 14.03.05 — «Фармакология». – Киев, 2016. [Taran IV. Modulation of diclofenac sodium gastrotoxicity in a different level of saturation of the body with hydrogen sulfide (experimental research). [dissertation] 14.03.05. Pharmacology. Kyiv; 2016. (In Ukr.)]
  16. Томаш О.В., Руденко Н.Н., Юренко Е.А. Антисекреторная терапия в реальной клинической практике: от привычных стереотипов к доказательным стандартам // Український терапевтичний журнал. – 2011. – № 2. – С. 103–114. [Tomash OV, Rudenko NN, Yurenko EA. Antisecretory therapy in real clinical practice: from habitual stereotypes to evidentiary standards. Ukrainian therapeutic journal. 2011;(2):103-114. (In Russ.)]
  17. Ульянина Л.Р., Ильин Д.А., Каримова Д.Р. Экспериментальная оценка гастропротекторной активности L-метионина и лития L-метионината на модели индометациновой язвы желудка / Материалы 88-й Всероссийской научно-практической конференции студентов и молодых ученых, посвященной 200-летию Казанского государственного медицинского университета. – 2014. – С. 175. [Ulyanina LR, Il’in DA, Karimova DR. Experimental evaluation of gastroprotective activity of L-methionine and lithium L-methioninate on the model of indometacin gastric ulcer. (Conference proceedings) Materials of the 88th All-Russian Scientific and Practical Conference of Students and Young Scientists, dedicated to the 200th anniversary of the Kazan State Medical University. 2014:175. (In Russ.)]
  18. Успенский Ю.П., Барышникова Н.В., Орлов О.Ю., Александрова Ю.А. НПВП-ассоциированная патология желудочно-кишечного тракта: выбор препарата, тактика ведения пациентов // Справочник поликлинического врача. – 2014. – № 8. – С. 42–47. [Uspensky YuP, Baryshnikova NV, Orlov OYu, Alexandrova YuA. NSAID-associated pathology of the gastrointestinal tract: the choice of the drug, the tactics of patient management. Reference book of the polyclinic doctor. 2014;(8):42-47. [(In Russ.)]
  19. Фоменко І.С. Вплив нестероїдних протизапальних препаратів на показники систем NO та H2S в слизовій оболонці товстої кишки // Вісник Київського національного університету імені Тараса Шевченка. – 2015. – № 18 (1). – С. 45–47. [Fomenko IS. Influence of nonsteroidal anti-inflammatory drugs on indicators of NO and H2S systems in the mucous membrane of the colon. Bulletin of the Taras Shevchenko National University of Kyiv. 2015;18(1):45-47. (In Russ.)]
  20. Холодов Д.Б., Николаевский В.А., Сулейманов С.М., и др. Фармакологическая коррекция ульцерогенного действия НПВС // Экспериментальная и клиническая фармакология. – 2014. – № 77 (7). – С. 20–22. [Kholodov DB, Nikolaevsky VA, Suleimanov SM, et al. Pharmacological correction of the ulcerogenic effect of NSAIDs. Experimental and clinical pharmacology. 2014;77(7):20-22. (In Russ.)]
  21. Andersen JT, Mastrogiannis D, Andersen NL, et al. Diclofenac/misoprostol during early pregnancy and the risk of miscarriage: a Danish nationwide cohort study. Arch Gynecol Obstet. 2016;294(2):245-250. doi: 10.1007/s00404-015-3966-9.
  22. Barinov E, Sulaieva O, Lyakch Y, et al. Platelet aggregation measurement for assessment of hemostasis failure mechanisms in patients with gastroduodenal ulcer bleeding. Clin Exp Gastroenterol. 2013;6:139-148. doi: 10.2147/CEG.S45685.
  23. Blackler RW, Gemici B, Manko A, Wallace JL. NSAID-gastroenteropathy: new aspects of pathogenesis and prevention. Curr Opin Pharmacol. 2014;11:11-16. doi: 10.1016/j.coph.2014.05.008.
  24. Cot GA, Howden CW. Potential adverse effects of proton pump inhibitors. Curr Gastroenterol Rep. 2008;10(3):208-214. doi: 10.1097/MOG.0b013e328358d5b9.
  25. D’Ayala GG, Malinconico M, Laurienzo P. Marine derived polysaccharides for biomedical applications: chemical modification approaches. Molecules. 2008;13:2069-2106. doi: 10.3390/molecules13092069.
  26. Dillon CT, Hambley TW, Kennedy BJ, et al. Gastrointestinaltoxicity, antiinflammatory activity, and superoxide dismutaseactivity of copper and zinc complexes of the antiinflammatorydrug indomethacin. Chem Res Toxicol. 2003;16:28-37. doi: 10.1021/tx020078o.
  27. Drepper M, Spahr L, Frossard J. Clopidogrel and proton pump inhibitors-where do we stand in 2012? World J Gastroenterol. 2012;18:2161-71. doi: 10.3748/wjg.v18.i18.2161.
  28. Fornai M, Colucci R, Antonioli L. Effects of esomeprazole on healing of nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers in the presence of a continued NSAID treatment: Characterization of molecular mechanisms. Pharmacol Res. 2011;63(1):59-67. doi: 10.1016/j.phrs.2010.10.013.
  29. Garg A, Shoeb A, Subramanya Moodahadu L, et al. Amtolmetin: a reappraisal of NSAID with gastroprotection. Hindawi Publishing Corporation Arthritis. 2016; Article ID7103705:1-5. doi: 10.1155/2016/7103705.
  30. Gemici B, Elsheikh W, Feitosa KB, et al. H2S-releasing drugs: anti-inflammatory, cytoprotective and chemopreventative potential. Nitric Oxide. 2015;46:25-31. doi: 10.1016/j.niox.2014.11.010.
  31. Grosskopf F. Carbenoxolon in treatment of stomach ulcer, duodenal ulcer and ulcerative colitis. Zeitschrift für Allgemeinmedizin. 1972;48(30):1411-4114.
  32. Holzer P. Neural emergency system in the stomach. Gastroenterology. 1998;114:823-839. doi: 10.1016/S0016-5085(98)70597-9.
  33. Jarosz M, Szkaradek N, Marona H, et al. Evaluation of anti-inflammatory and ulcerogenic potential of zinc-ibuprofen and zinc-naproxen complexes in rats. Inflammopharmacology. 2017;25(6):653-663. doi: 10.1007/s10787-017-0361-0.
  34. Magierowski M, Magierowska K, Kwiecien S, Brzozowski T. Gaseous mediators nitric oxide and hydrogen sulfide in the mechanism of gastrointestinal integrity, protection and ulcer healing. Molecules. 2015;20(5):9099-123. doi: 10.3390/molecules20059099.
  35. Malagelada J, De la Serna R, Dammann H. Sucralfate therapy in NSAID bleeding gastropathy. Clin Gastroenterol Hepatol. 2003;1:51-56.
  36. Moncada S, Higgs EA. The discovery of nitric oxide and its role in vascular biology. Br J Pharmacol. 2006;147(Suppl1):193-201.
  37. Motta JP, Flannigan KL, Agbor TA, et al. Hydrogen sulfide protects from colitis and restores intestinal microbiota biofilm and mucus production. Inflamm Bowel Dis. 2015;21(5):1006-17. doi: 10.1097/MIB.0000000000000345.
  38. Mozsik G. Capsaicin as a new orally applicable gastroprotective and therapeutic drug alone or in combination in human healthy subjects and in patients. Prog Drug Res. 2014;68:209-258. doi: 10.1007/978-3-0348-0828-69.
  39. Mozsik G, Omar Abdel-Salam ME, Takeuchi K. Capsaicin – sensitive neural afferentation and the gastrointestinal tract: from bench to bedside. InTech, Croatia. 2014. doi: 10.5772/57289.
  40. Norgard N, Mathews K, Wall G. Drug-drug interaction between clopidogrel and the proton pump inhibitors. Ann Pharmacother. 2009;43:1266-74. doi: 10.1345/aph.1M051.
  41. Perez-Aisa A, Castro M, Munoz M. Risk of upper and lower gastrointestinal bleeding in patients taking nonsteroidal anti-inflammatory drugs, antiplatelet agents, or anticoagulants. Clin Gastroenterol Hepatol. 2015;13:906-912. doi: 10.1016/j.cgh.2014.11.007.
  42. Rasulov MM, Kuznetsov IG, Slutskii LI. Solcoseryl: Ulcerostatic effect and its possible mechanisms. Bull Exp Biol Med. 1993;115(1):52-54. doi: 10.1007/BF00846359.
  43. Sanchez-Fidalgo S, Martin-Lacave I, Illanes M, et al. Administration of L-arginine reduces the delay of the healing process caused by ibuprofen. Implication of COX and growth factors expression. Histol Histopathol. 2005;20(2):437-447. doi: 10.14670/HH-20.437.
  44. Satoh H, Takeuchi K. Management of NSAID/aspirin-induced small intestinal damage by GI-sparing NSAIDs, anti-ulcer drugs and food constituents. Current Medicinal Chemistry. 2012;19(1):82-89.
  45. Scheiman J, Hindley C. Strategies to optimize treatment with NSAIDs in patients at risk for gastrointestinal and cardiovascular adverse events. Clin Ther. 2010. doi: 10.1016/j.clinthera.2010.04.009.
  46. Shaikh Omar OA, Bukhari HM, El Sawy NA. Efficacy of capsicum frutescens in curing the peptic ulcer. International Journal of Pure and Applied Sciences and Technology. 2013;15(1):43-54.
  47. Shih AR, Misdraji J. Drug-induced pathology of the upper gastrointestinal tract. Diagnostic Histopathology. 2017;23(2):84-95. doi: 10.1016/j.mpdhp.2017.03.002.
  48. Sibbing D, Morath T, Stegherr J, et al. Impact of proton pump inhibitors on the antiplatelet effects of clopidogrel. Thromb Haemost. 2009;101:714-19.
  49. Singh DP, Borse SP, Nivsarkar M. Co-administration of quercetin with pantoprazole sodium prevents NSAID-induced severe gastroenteropathic damage efficiently: Evidence from a preclinical study in rats. Exp Toxicol Pathol. 2017;69(1):17-26. doi: 10.1016/j.etp.2016.10.004.
  50. Small D, Farid N, Payne C, et al. Effects of the proton pump inhibitor lansoprazole on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel. J Clin Pharmacol. 2008;48:475-84. doi: 10.1177/0091270008315310.
  51. Sulaieva O, Obraztsova N. Role of vagus nerve in gastroduodenal adaptation and cytoprotection. American Journal of Clinical and Experimental Medicine. 2014;2(2):22-27. doi: 10.11648/j.ajcem.20140202.13.
  52. Sun K, Shi Y, Wang X, & Li Z. Sorption and retention of diclofenac on zeolite in the presence of cationic surfactant. Journal of hazardous materials. 2017;323:584-592. doi: 10.1016/j.jhazmat.2016.08.026.
  53. Tkach S, Onischuk L, Balabantseva A. Efficacy and safety of Rebamipide in prevention of NSAID-gastropathy. International Journal of BioMedicine. 2017;7(1):57-59. doi: 10.21103/Article7(1)_ShC1.
  54. Wallace JL, Caliendo G, Santagada V, Cirino G. Markedly reduced toxicity of a hydrogen sulphide-releasing derivative of naproxen (ATB-346). Br J Pharmacol. 2010;159:1236-46. doi: 10.1111/j.1476-5381.2009.00611.x.
  55. Wallace JL, Caliendo G, Santagada V, et al. Gastrointestinal safety and anti-inflammatory effects of a hydrogen sulfide-releasing diclofenac derivative in the rat. Gastroenterology. 2007;132:261-271.
  56. Wallace JL, Wang R. Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter. Nat Rev Drug Discov. 2015;14:329-345. doi: 10.1038/nrd4433.
  57. Zanardo RC, Brancaleone V, Distrutti E, et al. Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation. FASEB J. 2006;20:2118-2120.
  58. Zanellato I, Bonarrigo I, Ravera M, et al. The hexacarbonyldicobalt derivative of aspirin acts as a CO-releasing NSAID on malignant mesothelioma cells. Metallomics. 2013;5:1604-13. doi: 10.1039/c3mt00117b.
  59. Zayachkivska OS, Konturek SJ, Drozdowicz D, et al. Gastroprotective effects of flavonoids in plant extracts. Journal of Physiology and Pharmacology. Supplement. 2005;56(1):219-231. PMID: 15800396.
  60. Zupanets IA, Shebeko SK, Popov OS, Shalamay AS. Diclocor is superior to diclofenac sodium and quercetin in normalizing biochemical parameters in rats with collagen-induced ostheoarthritis. Inflammopharmacology. 2016;24(1):53-57. doi: 10.1007/s10787-015-0258-8.

Views

Abstract - 762

PDF (Russian) - 138

PlumX


Copyright (c) 2017 Hladkykh F.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.