Pharmacokinetic peculiarities of intravenous and oral ciprofloxacin administration in preoperative prophylaxis in patients with benign prostatic hyperplasia


The study of population pharmacokinetics of ciprofloxacin at various ways of administration helps to found that the once usage of 500 mg ciprofloxacin orally 90-120 min before the surgery as preoperative antibiotic prophylaxis with transurethral resection of the prostate gland creates a significantly higher concentration of the drug in blood, urine and prostate parenchyma compared to intravenously administration of 400 mg ciprofloxacin 30-60 min before operation. Thus, the data obtained explain the higher efficacy of oral administration of ciprofloxacin as preoperative antibiotic prophylaxis in patients undergoing transurethral resection of the prostate.

Igor Vladimirovich Sosin

Smolensk regional clinical hospital


Vladimir Vitalevich Rafalskiy

Smolensk State Medical Academy

Dr. Med. Sci. (Pharmacology), Professor, Dept. of Administration and Economic of Pharmacy

Petr Dmitriyevich Shabanov

Kirov Military Medical Academy

Doct. of Med. Sci. (Pharmacology), Professor and Head, Dept. of Pharmacology

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