Expediency of application of animals with the spontaneous hypertensia for modelling of the metabolic syndrome
- Authors: Kovaleva M.A.1, Makarova M.N.1, Selezneva A.I.2, Makarov V.G.1
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Affiliations:
- Mechnikov North-West State Medical University
- Saint-Petersburg institute of pharmacy
- Issue: Vol 10, No 4 (2012)
- Pages: 91-94
- Section: Articles
- Submitted: 21.10.2015
- Published: 15.12.2012
- URL: https://journals.eco-vector.com/RCF/article/view/757
- DOI: https://doi.org/10.17816/RCF10491-94
- ID: 757
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Abstract
When used within 11 weeks of diet “cafeteria diet” in spontaneously-hypertensive animals could lead to an increase in systolic blood pressure by 9%, sustained hyperglycemia, increased blood concentrations of triglycerides and cholesterol, as well as an increase in the relative content of visceral fat. In normotensive animals line Wistar-Kyoto prolonged use of “cafeteria diet” was accompanied only by an increase in blood glucose, cholesterol and triglycerides. Thus, the spontaneously hypertensive animals, the application of high-calorie diet demonstrated by three criteria pathogenesis of the metabolic syndrome: hyperglycemia, hypertension and visceral obesity, which allows you to use the model for the study of drugs aimed at treatment of metabolic syndrome.
About the authors
Maria Alexandrovna Kovaleva
Mechnikov North-West State Medical University
Email: makarov@ipharm.sp.ru
junior researcher
Marina Nikolayevna Makarova
Mechnikov North-West State Medical University
Email: mmn2410@yandex.ru
PhD
A. I. Selezneva
Saint-Petersburg institute of pharmacy
Email: alexs79@mail.ru
Valeriy Gennadyevich Makarov
Mechnikov North-West State Medical University
Email: makarov@ipharm.sp.ru
PhD, ScD, professor.