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Influence of metaprot and hypoxen on the inflammatory reaction development in the experiment
- Authors: Novikov V.Y.1, Ilyukhin S.A.1, Pozhilova Y.V.1
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Affiliations:
- Smolensk State Medical Academy
- Issue: Vol 10, No 4 (2012)
- Pages: 63-66
- Section: Articles
- URL: https://journals.eco-vector.com/RCF/article/view/752
- DOI: https://doi.org/10.17816/RCF10463-66
- ID: 752
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Abstract
The dynamics of the acute inflammatory response was observed in the experiment modeling caragenin-induced rat paw inflammation. The changes in the volume of damaged limb (paw edema) and indices of free radical oxidation were registered. Acetylsalicylic acid in the dose of 100 mg/kg was shown to reduce the development of inflammation. Hypoxen and metaprot in the dose of 50 mg/kg have got low anti-inflammatory activity, but potentiated the effect of acetylsalicylic acid. Simultaneous enteral administration of hypoxen and metaprot with the acetylsalicylic acid during the treatment with caragenin the powerful anti-inflammatory effect was marked, it was presented with a significant decrease in the parameters of inflammation recorded and rapid recovery of the damaged limb. The combination of hypoxen with acetylsalicylic acid was the most effective one.
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About the authors
Vasiliy Yegorovich Novikov
Smolensk State Medical Academy
Email: novikov.farm@yandex.ru
Doctor of Medical Sciences, professor, Head of the Department of Pharmacology
Sergey Alekseyevich Ilyukhin
Smolensk State Medical Academy
Email: chemtester@mail.ru
Postgraduate Fellow, Dept. of Pharmacology
Yelena Vasilyevna Pozhilova
Smolensk State Medical Academy
Email: nau@sgma.info
Postgraduate Fellow, Dept. of Pharmacology
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