Influence of metaprot and hypoxen on the inflammatory reaction development in the experiment

Abstract


The dynamics of the acute inflammatory response was observed in the experiment modeling caragenin-induced rat paw inflammation. The changes in the volume of damaged limb (paw edema) and indices of free radical oxidation were registered. Acetylsalicylic acid in the dose of 100 mg/kg was shown to reduce the development of inflammation. Hypoxen and metaprot in the dose of 50 mg/kg have got low anti-inflammatory activity, but potentiated the effect of acetylsalicylic acid. Simultaneous enteral administration of hypoxen and metaprot with the acetylsalicylic acid during the treatment with caragenin the powerful anti-inflammatory effect was marked, it was presented with a significant decrease in the parameters of inflammation recorded and rapid recovery of the damaged limb. The combination of hypoxen with acetylsalicylic acid was the most effective one.

Vasiliy Yegorovich Novikov

Smolensk State Medical Academy

Email: novikov.farm@yandex.ru
Doctor of Medical Sciences, professor, Head of the Department of Pharmacology

Sergey Alekseyevich Ilyukhin

Smolensk State Medical Academy

Email: chemtester@mail.ru
Postgraduate Fellow, Dept. of Pharmacology

Yelena Vasilyevna Pozhilova

Smolensk State Medical Academy

Email: nau@sgma.info
Postgraduate Fellow, Dept. of Pharmacology

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