Measles and rubella are two controlled airborne infections: etiopathogenesis, epidemiology, clinical picture, diagnosis, treatment and prevention. Part 1. Measles

Cover Page


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

The lecture is devoted to two infections controlled by specific means of prevention — measles and rubella, which still pose a danger both to the sphere of child and maternal health, and to healthcare in general.

The first part of the lecture is devoted to measles, one of the most contagious diseases, outbreaks of which can be successfully prevented through vaccination or, conversely, serve as an indicator of gaps in immunization programs and primary health care systems. The lecture covers modern aspects of etiopathogenesis, epidemiology, clinical picture, diagnosis, treatment and prevention of measles. In the context of an increase in the incidence of this infection in our country and a number of foreign countries in 2023, the information presented in the lecture may be useful for practitioners and, first of all, family doctors.

Full Text

Restricted Access

About the authors

Vladimir A. Neverov

North-Western State Medical University named after I.I. Mechnikov

Author for correspondence.
Email: v.neveroff@mail.ru
ORCID iD: 0009-0003-7951-5508
SPIN-code: 1798-2618

MD, Cand. Sci. (Med.), Assistant Professor

Russian Federation, Saint Petersburg

Galina I. Kirpichnikova

North-Western State Medical University named after I.I. Mechnikov

Email: sotnik26@bk.ru
ORCID iD: 0009-0004-8767-2332

Cand. Sci. (Biol.), Assistant Professor

Russian Federation, Saint Petersburg

Vsevolod M. Antonov

North-Western State Medical University named after I.I. Mechnikov

Email: Vsevolod.Antonov@szgmu.ru
ORCID iD: 0009-0002-3172-7926
SPIN-code: 9925-2139

Cand. Sci. (Med.), Assistant Professor

Russian Federation, Saint Petersburg

Galina Yu. Startseva

North-Western State Medical University named after I.I. Mechnikov

Email: star661@rambler.ru
ORCID iD: 0000-0002-3660-2666
SPIN-code: 8392-2950

MD, Cand. Sci. (Med.), Assistant Professor

Russian Federation, Saint Petersburg

Margarita V. Klur

North-Western State Medical University named after I.I. Mechnikov

Email: rita-med@mail.ru
ORCID iD: 0009-0006-6222-2452

MD, Cand. Sci. (Med.), Assistant Professor

Russian Federation, Saint Petersburg

References

  1. WHO EpiBrief: a report on the epidemiology of selected vaccine-preventable diseases in the European Region: N. 2/2023 [Internet]. Available from: https://www.who.int/europe/publications/i/item/WHO-EURO-2023-8231-48003-71091. Accessed: 24 Jan 2024.
  2. WHO EpiData N. 7/2023 [Internet]. Available from: https://www.who.int/europe/publications/m/item/epidata-7-2023. Accessed: 24 Jan 2024.
  3. Operational considerations for planning and implementing catch-up vaccination in the WHO European Region [Internet]. Available from: https://www.who.int/europe/publications/i/item/WHO-EURO-2022-4751-44514-63005. Accessed: 24 Jan 2024.
  4. Measles and rubella strategic framework 2021–2030. WHO. 2020 [Internet]. Available from: https://www.who.int/publications/i/item/measles-and-rubella-strategic-framework-2021-2030. Accessed: 24 Jan 2024.
  5. World Health Organization: Global distribution of measles and rubella genotypes — update. Wkly Epidemiol Rec. 2006;81(51/52):474–479.
  6. Moss WJ. Measles. Lancet. 2017;390(10111):2490–2502. doi: 10.1016/S0140-6736(17)31463-0
  7. Patel MK, Goodson JL, Alexander JP Jr, et al: Progress toward regional measles elimination — worldwide, 2000–2019. MMWR Morb Mortal Wkly Rep. 2020;69(45):1700–1705. doi: 10.15585/mmwr.mm6945a6
  8. De Francesco MA. Measles Resurgence in Europe: an open breakthrough in the field of vaccine-preventable diseases. Pathogens. 2023;12(10):1192. doi: 10.3390/pathogens12101192
  9. Fraser B. Measles outbreak in the Americas. Lancet. 2018;392(10145):373. doi: 10.1016/S0140-6736(18)31727-6
  10. WHO and CDC Joint News Release (5 December 2019) [Internet]. Available from: https://www.who.int/news/item/05-12-2019-more-than-140-000-die-from-measles-as-cases-surge-worldwide. Accessed: 24 Jan 2024.
  11. Buchanan R, Bonthius DJ. Measles virus and associated central nervous system sequelae. Semin Pediatr Neurol. 2012;19(3):107–114. doi: 10.1016/j.spen.2012.02.003
  12. Noyce RS, Bondre DG, Ha MN, et al. Tumor cell marker PVRL4 (nectin 4) is an epithelial cell receptor for measles virus. PLoS Pathog. 2011;7(8):e1002240. doi: 10.1371/journal.ppat.1002240
  13. Jiang Y, Qin Y, Chen M. Host–Pathogen interactions in measles virus replication and anti-viral immunity. Viruses. 2016;8(11):308. doi: 10.3390/v8110308
  14. Rima BK, Duprex WP. New concepts in measles virus replication: getting in and out in vivo and modulating the host cell environment. Virus Res. 2011;162:47–62. doi: 10.1016/j.virusres.2011.09.021
  15. Sakamoto K, Konami M, Satoh Y, et al. Suppression of viral RNA polymerase activity is necessary for persistent infection during the transformation of measles virus into SSPE virus. PLoS Pathog. 2023;19(7):e1011528. doi: 10.1371/journal.ppat.1011528
  16. Clinical recommendations (treatment protocol) for providing medical care to children with measles. 2015 [Internet]. Available from: http://niidi.ru/dotAsset/eed9b132-1dc0-4adc-8833-092e5e36fa66.pdf. Accessed: 06.07.2023. (In Russ.)
  17. Sudfeld CR, Navar AM, Halsey NA. Effectiveness of measles vaccination and vitamin A treatment. Int J Epidemiol. 2010;39 Suppl 1(Suppl 1):i48–55. doi: 10.1093/ije/dyq021

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2024 Eco-Vector

License URL: https://eco-vector.com/for_authors.php#07
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 70763 от 21.08.2017 г.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies