Email this article Prevalence of polymorphism of АDRВ1, AGT, SOD2, CAT genes and their combinations to assess the risk of developing cardiovascular disease
- Authors: Golovanova N.E.1,2, Astratenkova I.V.1, Lukyanova I.Y.1,2, Basanko A.V.3
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Affiliations:
- Saint Petersburg State University
- North-Western State Medical University named after I.I. Меchnikov
- Thumbay University Hospital
- Issue: Vol 28, No 1 (2024)
- Pages: 35-41
- Section: Original studies
- URL: https://journals.eco-vector.com/RFD/article/view/624814
- DOI: https://doi.org/10.17816/RFD624814
- ID: 624814
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Abstract
BACKGROUND: Cardiovascular disease remains a major public health problem associated with high mortality. The development of these diseases is associated with many genetic and cardiovascular risk factors, so the study of a person’s genetic predisposition to the development of cardiovascular disease based on gene polymorphism remains actual. The aim of research was to study the combination of polymorphisms of the ADRB1 rs1801253, AGT rs4762, SOD2 rs4880 and CAT rs1001179 genes in healthy young people to assess individual genetic predisposition to the development of cardiovascular disease.
MATERIALS AND METHODS: The study involved 33 people aged 19 to 21 years who currently had no pathology of the cardiovascular system. DNA was isolated from oral epithelial cells. Genotyping of DNA samples was determined using real-time polymerase chain reaction.
RESULTS: Among those examined, 39.4% had one or two unfavorable alleles for the ADRB1, AGT genes, suggesting a genetic predisposition to the development of cardiovascular disease. Unfavorable alleles of the ADRB1 gene were more common compared to the AGT gene. Each of those examined at risk of developing cardiovascular disease had one or two alleles associated with a decrease in the functioning of enzymes of the antioxidant system. Of the 33 people, only four (12.1%) do not have an unfavorable allele for the SOD2 and CAT genes.
CONCLUSIONS: We believe that the determination of polymorphisms in genes for enzymes of the antioxidant system will be an important additional criterion for earlier and more active prevention of cardiovascular disease.
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About the authors
Natalya E. Golovanova
Saint Petersburg State University; North-Western State Medical University named after I.I. Меchnikov
Email: nesh1764@mail.ru
ORCID iD: 0000-0001-9286-8787
SPIN-code: 9598-4184
Cand. Sci. (Biol.), Assistant Professor
Russian Federation, Saint Petersburg; Saint PetersburgIrina V. Astratenkova
Saint Petersburg State University
Email: astratenkova@mail.ru
ORCID iD: 0000-0003-0533-1098
SPIN-code: 5045-2305
Cand. Sci. (Biol.), Assistant Professor
Russian Federation, Saint PetersburgIrina Yu. Lukyanova
Saint Petersburg State University; North-Western State Medical University named after I.I. Меchnikov
Email: irina.loukianova@yahoo.com
ORCID iD: 0000-0001-5124-1953
SPIN-code: 5325-8354
MD, Dr. Sci. (Med.), Professor
Russian Federation, Saint Petersburg; Saint PetersburgAleksandra V. Basanko
Thumbay University Hospital
Author for correspondence.
Email: aleksandra.basanko@gmail.ru
ORCID iD: 0009-0002-1213-5861
SPIN-code: 2738-5341
MD
United Arab Emirates, AjmanReferences
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