Features of the clinical course of a new coronavirus infection in students who were observed in the observator in the first and second wave of morbidity increasing

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Abstract


INTRODUCTION: The sudden appearance of a new coronavirus infection in the world has posed difficult challenges for science to determine the main clinical manifestations of this disease, as well as to approve standards for diagnosis, treatment and prevention. Research of the symptoms of mild COVID-19 is continuing. The data obtained in such studies are particularly relevant for primary care physicians.

THE AIM: To evaluate the features of the clinical course of COVID-19 among students of the North-Western State Medical University named after I.I. Mechnikov, placed in the observatory, during the first and second waves of rising morbidity.

MATERIALS AND METHODS: The study was conducted on the basis of the observatory of the NWSMU named after I.I. Mechnikov in two stages: in the period from 21.04.2020 to 31.08.2020 (the first wave) and from 16.09.2020 to 31.12.2020 (the second wave). Demographic, epidemiological, and clinical-anamnestic data were recorded in all participants of the study.

RESULTS: The study involved 309 people: 39.8% men (n = 123) and 58.9% women (n = 182). The average age of the respondents was 21.5 ± 2.6 years. The number of participants in the first and second waves was 113 and 196 people, respectively. The average age of participants with COVID-19 in the first wave was 1.5 years less and was 21.2 ± 2.5 years (р < 0.001). There was a significant increase in the frequency of the following symptoms: dry cough, loss of smell, headache, general weakness, increased body temperature to 38.0 °С, nasal congestion (р < 0.05) in students who were monitored in the second wave of increased incidence of COVID-19 compared to the first. The frequency of symptoms such as chest congestion, lower back pain, and fever above 38.0 °С significantly decreased (р < 0.05). There was a significant decrease in the incidence of viral pneumonia in patients who were observed during the second wave, compared with the data obtained during the first wave (р < 0.001).


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About the authors

Olga Yu. Kuznetsova

North-Western State Medical University named after I.I. Mechnikov

Email: oukuznetsova@mail.ru
ORCID iD: 0000-0002-2440-6959
SPIN-code: 7200-8861
Scopus Author ID: 24448739500
ResearcherId: O-4056-2014

Russian Federation, 41 Kirochnaya str., Saint Petersburg, 191015

MD, PhD, DSc, Professor

Anna V. Lubimova

North-Western State Medical University named after I.I. Mechnikov

Email: lubimova@gmail.com
SPIN-code: 8967-4868
ResearcherId: O-9927-2014

Russian Federation, 41 Kirochnaya str., Saint Petersburg, 191015

MD, PhD, DSc, Associate Professor, Professor

Karina V. Ovakimyan

North-Western State Medical University named after I.I. Mechnikov

Author for correspondence.
Email: ursa-alba@yandex.ru
ORCID iD: 0000-0002-5342-3918
SPIN-code: 5900-2849

Russian Federation, 41 Kirochnaya str., Saint Petersburg, 191015

MD, PhD

Olga I. Frolova

North-Western State Medical University named after I.I. Mechnikov

Email: frol13-13@list.ru

Russian Federation, 41 Kirochnaya str., Saint Petersburg, 191015

Resident of the Department of Family Medicine

Olga S. Zamyatina

North-Western State Medical University named after I.I. Mechnikov

Email: olyazamiatina@yandex.ru
ORCID iD: 0000-0001-7011-7157

Russian Federation, 41 Kirochnaya str., Saint Petersburg, 191015

district physician, resident of the Department of Family Medicine

Svyatoslav O. Durkin

North-Western State Medical University named after I.I. Mechnikov

Email: durkin.svyatoslav@mail.ru

Russian Federation, 41 Kirochnaya str., Saint Petersburg, 191015

ординатор кафедры семейной медицины

References

  1. Coronavirus disease 2019. Update April 14, 2020 [Internet]. Available from: https://www.lecturio.com/covid-19-coronavirus-disease-2019. Accessed 24.03.2021.
  2. Perez-Saez J, Lauer S, Kaiser L, et al. Serology-informed estimates of SARS-CoV-2 infection fatality risk in Geneva, Switzerland. Lancet Infect Dis. 2020;21(4):e69–e70. doi: 10.1016/S1473-3099(20)30584-3
  3. Gold MP, Sehayek D, Gabrielli S, et al. COVID-19 and comorbidities: a systematic review and meta-analysis. Postgrad Med. 2020;132(8):749–755. doi: 10.1080/00325481.2020.1786964
  4. Jain V, Yuan J-M. Predictive symptoms and comorbidities for severe COVID-19 and intensive care unit admission: a systematic review and meta-analysis. Int J Public Health. 2020;65(5):533–546. doi: 10.1007/s00038-020-01390-7
  5. Vremennye metodicheskie rekomendatsii. Profilaktika, diagnostika i lechenie novoi koronavirusnoi infektsii (COVID–19) [Internet]. Available from: https://static-0.minzdrav.gov.ru/system/attachments/attaches/000/054/588/original/Временные_МР_COVID-19_%28v.10%29-08.02.2021_%281%29.pdf. Accessed 24.03.2021. (In Russ.)
  6. Chakraborty G, Sharma AR, Sharma G, et al. SARS-CoV-2 causing pneumonia-associated respiratory disorder (COVID-19): diagnostic and proposed therapeutic options. Eur Rev Med Pharmacol Sci. 2020;24(7):4016–4026. doi: 10.26355/eurrev_202004_20871
  7. The epidemiological characteristics of an outbreak of 2019 novel Coronavirus Diseases (COVID-19). China CDC Weekly. 2020;2(8):113–122. doi: 10.46234/ccdcw2020.032
  8. Kuznetsova OYu, Lyubimova AV, Ovakimyan KV, et al. Features of the clinical course of a new coronavirus infection in students who were under observation in the observatory. Russian family doctor. 2020;24(4):5–12. (In Russ.) doi: 10.17816/RFD57155
  9. Iftimie S, López-Azcona AF, Vallverdú I, et al. First and second waves of coronavirus disease-19: A comparative study in hospitalized patients in Reus, Spain [Internet]. Available from: https://doi.org/10.1101/2020.12.10.20246959. Accessed 23.03.2021.
  10. Sayganov SA, Meltser AV, Liubimova AV, et al. Experience in measures development to prevent spread of new coronavirus disease among students of educational organization living in dormitories. Preventive and clinical medicine. 2020;76(3):4–11. (In Russ.)
  11. Klinicheskoe issledovanie preparatov dlya lecheniya COVID-19 “Solidarity”. WHO [Internet]. Available from: https://www.who.int/ru/emergencies/diseases/novel-coronavirus-2019/global-research-on-novel-coronavirus-2019-ncov/solidarity-clinical-trial-for-covid-19-treatments. Accessed 23.03.2021.
  12. EVMS Critical care protocol COVID19 [Internet]. Available from: https://www.evms.edu/media/evms_public/departments/internal_medicine/EVMS_Critical_Care_COVID-19_Protocol.pdf. Accessed 23.03.2021.
  13. Meng X, Deng Ya, Dai Z, Meng Z. COVID-19 and anosmia: A review based on up-to-date knowledge. Am J Otolaryngol. 2020;41(5):102581. doi: 10.1016/j.amjoto.2020.102581
  14. Reinhard A, Ikonomidis Ch, Broome M, Gorostidi F. Anosmia and COVID-19. Rev Med Suisse. 2020;16(691-2):849–851. (In French)
  15. Vaira LA, Salzano G, Fois AG, et al. Potential pathogenesis of ageusia and anosmia in COVID-19 patients. Int Forum Allergy Rhinol. 2020;10(9):1103–1104. doi: 10.1002/alr.22593

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Copyright (c) 2021 Kuznetsova O.Y., Lubimova A.V., Ovakimyan K.V., Frolova O.I., Zamyatina O.S., Durkin S.O.

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