QUALITY OF LIFE OF PATIENTS WITH ASTHMA: THE EFFECTS OF OVERWEIGHT, OBESITY AND MULTIMORBIDITY



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Abstract

Aim. To assess the effect of personalizing features (obesity and multimorbidity) on the quality of life of patients with different levels of asthma control.

Materials and methods. patients with asthma (n=237) were divided into 3 groups depending on BMI. Multimorbid pathology was analyzed by pathology scale (CIRS), asthma control - ACQ-5; quality of life - AQLQ(S) questionnaire. Statistical analysis: MS Excel, Statistica 12.0, Statgraphics XVIII.

Results. Patients with obesity and asthma had more comorbidities (p<0.05). Quality of life in patients with high and normal body weight depended on the level of control and the number of diseases (p<0.05), with getting worse disease control these differences became insignificant. In the group with obesity, activity limitation (p=0.0150) and overall quality of life (p<0.005) increased significantly with increasing  number of diseases. Anxiety levels increased with increasing number of illnesses (p<0.0001). quality of life of patients according to AQLQ(S) has inverse correlation with BMI (r=-0.5135), age (r=-0.2034) with CIRS scores (r=-0.4905) with anxiety (r=-0.5078) and depression (r=-0.4820) level.

Conclusion. Body weight, level of asthma control, depression and anxiety, and the number of comorbid multimorbid conditions affect the quality of life of patients with asthma. Obesity makes a significant negative contribution to worsening asthma control and patients' quality of life, in this group patients have the highest level of multimorbidity and they have a prevalence of anxiety. To improve asthma control, patients need a complex examination including assessment of quality of life, depression and anxiety, and comorbidities in order to develop personalization of therapeutic approaches to patient management

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Ludmila Tribuntceva

Voronezh State Medical University named after N.N. Burdenko

编辑信件的主要联系方式.
Email: tribunzewa@yandex.ru
ORCID iD: 0000-0002-3617-8578
SPIN 代码: 1115-1877
Scopus 作者 ID: 57204948114

доцент, заведующая кафедрой терапевтических дисциплин ИДПО

俄罗斯联邦

Andrey Budnevsky

N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of Russia

Email: budnev@list.ru
ORCID iD: 0000-0002-1171-2746
SPIN 代码: 7381-0612
Researcher ID: L-7459-2016

MD, Professor, Head of the Department of Faculty Therapy, Vice-Rector for Scientific and Innovation Activities 

俄罗斯联邦, Voronezh

Galina Prozorova

N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of Russia

Email: prozorovagg@gmail.com
ORCID iD: 0000-0001-8675-1590
Researcher ID: GWV-5007-2022

MD, Associate Professor, Professor of the Department of Therapeutic Disciplines of the Institute of Additional Professional Education

俄罗斯联邦, Voronezh

Irina Olysheva

N.N. Burdenko Voronezh State Medical University of the Ministry of Healthcare of Russia

Email: irina.olysheva@gmail.com
ORCID iD: 0000-0002-9125-1969

PhD in Medical Sciences, Assistant at the Department of Therapeutic Disciplines of the Institute of Additional Professional Education

俄罗斯联邦, Voronezh

Roman Khokhlov

Voronezh State Medical University named after N.N. Burdenko; Voronezh Regional Clinical Consulting and Diagnostic Center

Email: visartis@yandex.ru
ORCID iD: 0000-0002-3539-026X
SPIN 代码: 7249-2667

MD, Dr. Sci. (Med.), Assistant Professor

俄罗斯联邦, 10, st. Studencheskaya, 394036, Voronezh; 5А Lenina Square, Voronezh, 394018

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