Osteoporosis Prevalence in Women in the Urals Rural Area

Cover Page


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

BACKGROUND: The rural population of the Russian Federation is underrepresented in osteoporosis studies.

AIM: The aim of the study was to evaluate the prevalence of osteoporosis in rural women of the Urals aged ≥ 50 years.

METHODS: A cluster comprehensive observational study was conducted in 2240 residents of a rural settlement in the Urals. Osteoporosis rates were based on fracture data obtained using a FRAX algorithm and dual-energy X-ray absorptiometry (DXA).

RESULTS: A history of fragility fractures was reported in 15% of the study subjects. An additional 4.4% of patients were diagnosed with osteoporosis using DXA. When other clinical data and FRAX scores were analyzed in subjects who declined DXA, the osteoporosis rates in the study population reached 21.2% and showed an increase with age.

CONCLUSION: The prevalence of osteoporosis in rural women aged ≥ 50 years was 21.2%, and osteoporosis rates increased with age, reaching 38.7% in subjects aged ≥ 85 years. FRAX has been shown to be effective in identifying women at intermediate and high risk of fracture in rural areas, in combination with diagnostic and therapeutic intervention thresholds specific to Russia. Low awareness of osteoporosis in patients with fragility fractures requires a coordinated primary care approach, including osteoporosis education programs for rural populations. Clinical decision making for osteoporosis therapy in 11% of rural women was based on a highly specific intervention threshold calculated using FRAX without consideration of DXA data.

Full Text

Restricted Access

About the authors

Vera G. Kondakova

Nevyansk Central District Hospital

Author for correspondence.
Email: KondakovaGP@gmail.com
ORCID iD: 0000-0001-7272-7311
SPIN-code: 8710-8403

MD

Russian Federation, Nevyansk, Sverdlovsk Region

Alla G. Zakroyeva

Ural State Medical University

Email: zakroeva.alla@mail.ru
ORCID iD: 0000-0003-4839-4427
SPIN-code: 8248-6920

MD, Dr. Sci. (Medicine)

Russian Federation, Ekaterinburg

Svyatoslav I. Zverev

Irbit Central Hospital

Email: zverevsv@live.ru
ORCID iD: 0009-0007-5120-0263
SPIN-code: 3299-4259

MD

Russian Federation, Irbit, Sverdlovsk Region

References

  1. Lesnyak OM, Baranova IA, Belova KYu, et al. Osteoporosis in Russian Federation: Epidemiology, socio-medical and economical aspects (review). Traumatology and Orthopedics of Russia. 2018;24(1):155–168. EDN: YVGNSE doi: 10.21823/2311-2905-2018-24-1-155-168
  2. Nguyen ND, Ahlborg HG, Center JR, et al. Residual lifetime risk of fractures in women and men. J Bone Miner Res. 2007;22(6):781–788. doi: 10.1359/jbmr.070315
  3. Dyer SM, Crotty M, Fairhall N, et al. A critical review of the long-term disability outcomes following hip fracture. BMC Geriatr. 2016;16(1):158. doi: 10.1186/s12877-016-0332-0
  4. Ershova OB, Belova KYu, Degtyarev AA, et al. Analysis of mortality in patients with a fracture of the proximal femur. Osteoporosis and Bone Diseases. 2015;18(3):3–8. EDN: XQVYSR doi: 10.14341/osteo201533-8
  5. Lesnyak OM. The new paradigm in diagnosis and treatment of osteoporosis: prediction of a 10-year absolute risk of fracture (calculator FRAX). Osteoporosis and Bone Diseases. 2012;15(1):23–28. EDN: PXBHYJ
  6. Lesnyak OM, Yershova OB, Belova KYu, et al. Epidemiology of osteoporotic fractures in the Russian federation and the Russian model of FRAX. Osteoporosis and Bone Diseases. 2014;17(3):3–8. EDN: RUAQYW doi: 10.14341/osteo201433-8
  7. Larina TN, Yuzaeva Y.R. Analysis of changes in the rural settlement system of Russia (based on census data). Intellect. Innovations. Investments. 2012;(1):48–51. EDN: PUIGMD
  8. Mikhailyuk SF, Mikhailyuk RA. Elderly people in rural areas – a special group of medical and social risk. Clinical Gerontology. 2010;16(9–10):54–55. EDN: MWNCAZ
  9. Rothman KJ, Greenland S, Lash TL. Modern Epidemiology. Fourth edition. Wolters Kluwer; 2021.
  10. Belaya ZhE, Belova KYu, Biryukova EV, et al. Federal clinical guidelines for diagnosis, treatment and prevention of osteoporosis. Osteoporosis and Bone Diseases. 2021;24(2):4–47. EDN: TUONYE doi: 10.14341/osteo12930
  11. Clinical recommendations “Pathologic fractures complicating osteoporosis” (approved by the Ministry of Health of the Russian Federation, 2022). Available from: https://base.garant.ru/404774207/. Accessed: 18 Feb 2025. (In Russ.)
  12. Kanis JA, Oden A, Johnell O, et al. The burden of osteoporotic fractures: a method for setting intervention thresholds. Osteoporos Int. 2001;12(5):417–427. doi: 10.1007/s001980170112
  13. Evstigneeva LP, Kondakova VG, Dubowskoj AV, Avramenkova KG. Approaches to organization of fracture liaison services at the regional level with the involvement of primary care physicians. Osteoporosis and Bone Diseases. 2022;25(4):21–27. EDN: FQQXWU doi: 10.14341/osteo12961
  14. Myagkova MA, Skripnikova IA, Kosmatova OV, et al. Associations of absolute risk of osteoporotic fractures (frax®) and total cardiovascular risk (score) in urban population of the Russian Federation. Cardiovascular Therapy and Prevention. 2019;18(5):108–116. EDN: NDATFV doi: 10.15829/1728-8800-2019-5-108-116
  15. Benevolenskaya LI, editor. Manual on osteoporosis. Moscow: BINOM; 2003. 523 p. (In Russ.)
  16. Nikitinskaya OA, Toroptsova NV. Social program “osteoscreening Russia” at work. Farmateka. 2012;6(239):90–93. EDN: PACXJZ
  17. Gladkova EN, Tanaev VG, Lesnyak OM, et al. The effectiveness of screening to identify patients with osteoporosis/high risk of fractures in primary health care. Osteoporosis and Bone Diseases. 2022;25(1):14–22. EDN: MODYDH doi: 10.14341/osteo12946
  18. Salari N, Darvishi N, Bartina Y, et al. Global prevalence of osteoporosis among the world older adults: a comprehensive systematic review and meta-analysis. J Orthop Surg Res. 2021;16:669. doi: 10.1186/s13018-021-02821-8
  19. Gladkova E, Khodyrev V, Lesnyak O, et al. Analysis of epidemiology of osteoporotic fractures using data from primary care physicians. Osteoporosis and Bone Diseases. 2011;14(1):14–18. EDN: OHKRRT doi: 10.14341/osteo2011114-18
  20. Belova KY, Evstigneeva LP, Lesnyak OM, et al. Organization of a secondary fracture prevention system. Expert group recommendations. Russian Journal of Preventive Medicine. 2024;27(8):26–31. EDN: PCMEEB doi: 10.17116/profmed20242708126

Supplementary files

Supplementary Files
Action
1. JATS XML
Download
2. Fig. 1. Diagnostic algorithm for osteoporosis in rural women aged ≥ 50 years living in Kalinovo village (n = 533).

Download (784KB)
Indexing metadata
3. Fig. 2. Distribution of patients with osteoporosis by 5-year age groups.

Download (106KB)
Indexing metadata

Copyright (c) 2025 Eco-Vector


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 70763 от 21.08.2017 г.