Association of apoprotein A-1 genetic variants with atherosclerosis development in Saint-Petersburg



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Abstract

Apoprotein A-1 is a major protein in antiaterogenic high density lipoproteins and it is one of key proteins regulating reverse cholesterol transport. In this study we have investigated association of APOA1 gene polymorphism with atherosclerosis development among Saint-Petersburg population. Allelic frequencies of polimorphic variants (-75)G/A and 83C/T of APOA1 gene were determined in the group of patients with angiographically proven aterosclerosis and in control group. Allele 83T of the APOA1 gene is associated with lower risk of atherosclerosis development among Saint-Petersburg population.

About the authors

Valentina V Miroshnikova

B.P. Konstantinov Nuclear Physics Institute, Gatchina, Leningrad Oblast, RF

Email: mutantropol@mail.ru

Tatyana I Rodygina

B.P. Konstantinov Nuclear Physics Institute, Gatchina, Leningrad Oblast, RF

Email: t_rodygina@mail.ru

Ekaterina P Demina

B.P. Konstantinov Nuclear Physics Institute, Gatchina, Leningrad Oblast, RF

Email: citritt@gmail.com

Pavel S Kuryanov

I. P. Pavlov First State Medical University, Saint-Petersburg, RF

Email: pkurjanov@gmail.com

Soreya A Urazgildeeva

I.I. Mechnikov State Medical Academy, St. Petersburg, RF

Email: s_urazgildeeva@hotmail.com

Victor S Gurevich

I.I. Mechnikov State Medical Academy, St. Petersburg, RF

Email: ater@med122.com

Alexander L Schwarzman

B.P. Konstantinov Nuclear Physics Institute, Gatchina, Leningrad Oblast, RF

Email: aschwart1@yandex.ru

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Copyright (c) 2010 Miroshnikova V.V., Rodygina T.I., Demina E.P., Kuryanov P.S., Urazgildeeva S.A., Gurevich V.S., Schwarzman A.L.

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