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Genetics and epigenetics of syntropic diseases
- Authors: Gorbunova V.N1
-
Affiliations:
- Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, RF
- Issue: Vol 8, No 4 (2010)
- Pages: 39-43
- Section: Articles
- URL: https://journals.eco-vector.com/ecolgenet/article/view/5432
- DOI: https://doi.org/10.17816/ecogen8439-43
- ID: 5432
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Abstract
The genetic components are involved in aetiology of the common human diseases. For most of them it is significant the phenomenon of syntropies — nonrandom combination of different diseases in the same patients. Three methodic approaches have been successfully used for the identification of genetic factors predisposed to the common human diseases: linkage analysis, candidate gene association studies (GASs) and genome-wide association scans (GWASs). The structural features of the many genes make a small but significant contribution to the overall risk of common diseases. Syntropy of related diseases is determined of having of share in disease pathogenesis the functional polymorphisms of genes controlling the same metabolic pathways. Nonrandom combination of different diseases in the same patients is determined of common epigenetic mechanisms involved in expression control of different «gene nets» disorder.
About the authors
Viktoriya N Gorbunova
Saint-Petersburg State Pediatric Medical University, Saint-Petersburg, RF
Email: vngor@mail.ru
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