THE ROLE OF TRANSCRIPTION FACTORS DFOXO, DSIR2 AND HSP70 IN LIFESPAN ALTERATION OF DROSOPHILA MELANOGASTER IN DIFFERENT LIGHT CONDITIONS



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Abstract

It was investigated the role of stress-response genes (dFOXO, dSir2, Hsp70) in regulation of life span of Drosophila in response to light regime alteration. It was revealed the FOXO-dependant mechanism of lifespan increasing at darkness conditions. The distance of lifespan of FOXO homozygous mutants at different light conditions were absent 3 times from 4 times. It was shown, that homozygotes with deletion of dSir2 have more significant difference between lifespan at standard light and darkness conditions with comparing to wild type and heterozygous strain. The same tendency was also detected the in the strains with Hsp70 deletions. It was produced the evidences of two mechanisms of light regime influence on lifespan: metabolism intensification at light conditions and neuroendocrine-determinated lifespan increasing at darkness conditions.

About the authors

Aleksey A Moskalev

Science Institute of Biology of the Komi Ural Branhc RAS, Syktyvkar, Komi Republic, RF

Email: amoskalev@list.ru

Olga A Malysheva

Science Institute of Biology of the Komi Ural Branhc RAS, Syktyvkar, Komi Republic, RF

Email: amoskalev@list.ru

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Copyright (c) 2010 Moskalev A.A., Malysheva O.A.

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