Melatonin influence on Drosophila melanogaster life span at different light regimes

Abstract


It was investigated the combined effects of different light regimes (round-the-clock lighting or darkening) and antioxidant melatonin on Drosophila melanogaster life span of wild type strain Canton-S,mutant strain with defect of red-ox system (Sod) and mu tant strain with disturbance of excision DNA repair (mus210). It was revealed, that maintenance of Drosophila imago at round-the-clock lighting leads to decrease of mean and/or maximum life span with compare to being at darkening. Adding of melatonin to Drosophila meal induces the geroprotector effects, mainly, in dark conditions. The effects mentioned above were most expressed in strain with mutation of Sod. All effects have revealed in both sexes. The data analysis has shown that mechanisms of different light regimes and melatonin influ ence on life span are rather different.

Aleksey A Moskalev

Science Institute of Biology of the Komi Ural Branhc RAS, Syktyvkar, Komi Republic, RF

Email: amoskalev@list.ru

Anna V Krementsova

N.M.Emanuel Institute of Biochemical Physics RAS, Moscow, RF

Olga A Malysheva

Science Institute of Biology of the Komi Ural Branhc RAS, Syktyvkar, Komi Republic, RF

Email: amoskalev@list.ru

  1. Анисимов В. Н., Мыльников С. В., Опарина Т. И., Хавинсон В. X., 1997. Влияние мелатонина и эпита-ломина на продолжительность жизни и перекисное окисление липидов у Drosophila melanogaster//Доклады АН. Т. 352. №5. С. 704-707.
  2. Анисимов В. Н., 2003. Молекулярные и физиологические механизмы старения. -СПб.: Наука, 468 с.
  3. Измайлов Д. М., Обухова Л. К., 1999. Мелатонин, как геропротектор: эксперименты с Drosophila melanogaster//Бюллетень экспериментальной биологии и медицины. Т. 27. №2. С. 205-207.
  4. Кременцова А. В., 2004. Сходство и различие в закономерности смертности людей и животных//Успехи геронтологии. Т. 15. С. 7-13.
  5. Москалев А. А., Шосталь О. А., Зайнуллин В. Г., 2006. Генетические аспекты влияния различных режимов освещения на продолжительность жизни дрозофилы//Успехи геронтологии. Т. 18. С. 55-58.
  6. Anisimov V. N., 2003. Effects of exogenous melatonin -a review//Toxicol. Pathol. Vol. 31. N 6. P. 589-603.
  7. Anisimov V. N., Mylnikov S. V., Oparina T. I., Khavinson V. K., 1997. Effect of melatonin and pineal peptide preparation epithalamin on life span and free radical oxidation in Drosophila melanogaster/'/Mech Ageing Dev.Vol.97 . N2. P. 81-91
  8. Anisimov V. N., Alimova I. N., Baturin D. A. et at, 2003. Dose-dependent effect of melatonin on life span and spontaneous tumor incidence in female SHR mice//Exp. Gerontol. Vol. 38. N 4. P. 449-461.
  9. Anisimov V. N., Baturin D. A., Popovich I. G., Za-bezhinski M. A., Manton K. G., Semenchenko A. V., Yashin A. I., 2004. Effect of exposure to light-at-night on life span and spontaneous carcinogenesis in female CBA mice//Int. J. Cancer. Vol. 111. P. 475-479.
  10. Anisimov V. N., Popovich I. G., Zabezhinski M. A. et at., 2006. Melatonin as antioxidant, geroprotector and anticarcinogen//Biochim. Biophys. Acta. Vol. 1757. N 5-6. P. 573-589.
  11. Armstrong S. M., Redman J. R., 1991. Melatonin: a chronobiotic with anti-aging properties?//Hypotheses. Vol. 34. P. 300-309.
  12. Bonilla E., Medina-Leendertz S., Diaz S., 2002 Extension of life span and stress resistance of Drosophila melanogaster by long-term supplementation with melatonin//Experimental Gerontology. Vol. 37. P. 629-638.
  13. Bonilla E., Medina-Leendertz S., Villalobos V.et al, 2006 Paraquat-induced oxidative stress in Drosophila melanogaster. effects of melatonin, glutathione, serotonin, minocycline, lipoic acid and ascorbic acid//Neurochem Res. Vol. 31. N 12. P. 1425-1432.
  14. Coto-Montes A, Hardeland R., 1999. Antioxidative effects of melatonin in Drosophila melanogaster: antagonization of damage induced by the inhibition of catalase.//J. Pineal Res. Vol. 27. N 3. P. 154-158.
  15. De HaanG., GelmanR., WatsonA. et al, 1998. APu-tative Gene Causes Variability in Lifespan Among Genotypically Identical Mice//Nature Genetics. Vol. 19. P. 114-116.
  16. Gompertz В., 1825. On the nature of the function expressive of the law of human mortality and on a new mode determining life contingencies//Philosophical Transactions of the Royal Society of London Ser A. V 115. P. 513-585.
  17. Hardeland R., 2005 Antioxidative protection by melatonin: multiplicity of mechanisms from radical detoxification to radical avoidance//Endocrine. Vol. 27. P. 119-130.
  18. Hardeland R., Coto-Montes A., Poeggeler B., 2003. Circadian rhythms, oxidative stress and antioxidative defense mechanisms//Chronobiol. Int. Vol. 20. P. 921-962.
  19. Hirsch H. R., 1995. Do intersections of mortality-rate and survival functions have significance?//Experimental Gerontology. Vol. 30. N 2. P. 147-167.
  20. Izmaylov D. M. Obukhova L. K., 1999. Geroprotector effectiveness of melatonin: investigation of lifespan of Drosophila melanogaster.//Mechanisms of Ageing and Development. Vol. 106. P. 233-240.
  21. Izmaylov D. M., Obukhova L. K., 2003. Life span variations in 128 successive generations of D. melanogaster. I. Evidence that the phenomenon exists and analysis of the variations mode.//Mech Ageing Dev. Vol. 124. N 5. P. 589-97.
  22. Le Bourg E., 2001. Oxidative stress, aging and longevity in Drosophila melanogaster//FEBS Letters. Vol.498. P. 183-186.
  23. Majercak J. M., 2002. The effects of light and temperature on the Drosophila circadian clock//Dissertation Abstracts International. Vol. 62. N 1. R 98.
  24. Massie H.R, Whitney S.J., 1991. Preliminary evidence for photochemical ageing in Drosophila//Mech. Ageing Dev. Vol. 58. N 1. P. 37-48.
  25. Massie H R., Aiello V. R., Williams T. R., 1993. Influence of photosensitizers and light on the life span of Drosophila//Mech. Ageing Dev. Vol. 68. N 1-3. P. 175-182.
  26. Oakninbendahan S., Anis Y., Nirl., Zisapel N., 1995. Effects of long-term administration of melatonin and a putative antagonist on the aging rat.//Neuroreport. Vol. 6. P. 785-788.
  27. Orr W. C., Sohal R. S., 2003. Does overexpression of Cu, Zn-SOD extend life span in Drosophila melanogaster?//Experimental gerontology. Vol. 38. P. 227-230.
  28. Pappolla M. A., Sos M., Omar R. A. et al., 1997. Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide//J. Neurosci. Vol. 17. N 5. P. 1683-1690.
  29. Phillips J. P., Tainer J. A., Getzoff E. D. et al., 1995. Subunit-destabilizing mutations in Drosophila copper/zinc superoxide dismutase: Neuropathology and a model of dimer dysequilibrium//Proc. Natl. Acad. Sci. USA. Vol. 92. P. 8574-8578.
  30. Pieri C., Moroni F., Marra M. et al., 1995. Melatonin is an efficient antioxidant.//Arch. Gerontol. Geriatr. Vol. 20. P. 159-165.
  31. Pierpaoli W., Regelson W., 1994. Pineal control of aging: effect of melatonin and pineal grafting in aging mice//Proc. Natl Acad. Sci. U.S.A. Vol.91. P. 787-791.
  32. Provinciali M., Di Stefano G., Bulian D. et al., 1996. Effect of melatonin and pineal grafting on thymocyte apoptosis in aging mice//Mech. Ageing Dev. Vol. 90. N 1.P. 1-19.
  33. Sainz R.M.,Mayo J. C, Uria H. et al., 1995. The pineal neurohormone melatonin prevents in vivo and in vitro apoptosis in thymocytes//J. Pineal. Res. Vol. 19. N 4. P. 178-188.
  34. Schelettwein-Gsell D., 1970. Survival curves of an old age rat colony//Gerontologia. Vol. 16. P. 111 -115
  35. Sekelsky J. J., Hollis K. J., Eimerl A. I. et al., 2000. Nucleotide excision repair endonuclease genes in Drosophila melanogaster//Mutat. Res. Vol. 459. N 3. P. 219-228.
  36. Sheeba V., Sharma V. K., Shubha K et al., 2000 The effect of different light regimes on adult life span in Drosophila melanogaster is partly mediated through reproductive output//J. Biol. Rhythms. Vol. 15. N5. P. 380-392.
  37. Sheeba V., Chandrashekaran M. K., Joshi A., Sharma V. K., 2002. Developmental plasticity of the locomotor activity rhythm of Drosophila melanogaster//J. Insect Physiol. Vol. 48. N1. P. 25-32.
  38. Strehler B. L., Mildvan A. S., 1960. General theory of mortality aging//Science. Vol. 132. P. 14-21.
  39. Yi C., Pan X., Yan H., Quo M., Pierpaoli W., 2005. Effects of melatonin in age-related macular degeneration//Ann N-Y Acad Sci. Vol. 1057. P. 384-392.

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