DNA metylation as one of the main mechanisms of gene activity regulation


 DNA methylation is one of the main mechanisms of epigenetic inheritance in eukaryotes. In this review we looked through the ways of 5-methylcytosin origin, it's distribution in genome, the mechanism of gene repression via hypermetilation, the role of metylation in genomic imprinting and in X-chromosome inactivation, in embryogenesis of mammals, in the processes of oncogenesis and in etiology of some common human inherited diseases

About the authors

Anna A Pendina

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: pendina@mail.ru

Vera V Grinkevich

Saint-Petersburg State University., Saint-Petersburg, RF

Tatyana V Kuznetsova

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: tkuznetzova@mail.ru

Vladislav S Baranov

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: baranov@vb2475.spb.edu


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CrossRef: 1

  1. Tsymbal O, Isubakova D, Bronikovskaya E, Milto I, Khalyuzova M, Litviakov N, et al. The Role of Bak1 Methylation in the Induction of Chromosomal Aberrations under Chronic Low-Intensity External Radiation. Medical Radiology and radiation safety. 2021;65(5):29. doi: 10.12737/1024-6177-2020-65-5-29-34


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