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Vol 2, No 1 (2004)

Genetic mechanisms encoding biological complexity
Suslov V.V., Gunbin K.V., Kolchanov N.A.
Increase in organism complexity is a global trend in evolution. Qualitatively extended complexity in eukaryotes in comparison to prokaryotes is provided by genome organization and genetic program realization. Genetic mechanisms of encoding biological complexity in pro- and eukaryotes are considered: above-triplet codes, combinatorial analysis of genetical blocks and gene network blocks, and their hierarchical interaction
Ecological genetics. 2004;2(1):13-26
Reactive oxygen species regulate gene networks of stress response
Stepanenko I.L.
The GeneNet (gnw/genenet/) accumulate information on reactive oxygen species (ROS) signals and reduction/oxidation (redox) regulation of transcription factors. Redox-regulation gene network is the adaptation to oxidative stress and integrative system of local gene networks via key transcription factors. The cross-talk of signals and the interference of gene networks occur in the integrative gene network
Ecological genetics. 2004;2(1):4-12
DNA metylation as one of the main mechanisms of gene activity regulation
Pendina A.A., Grinkevich V.V., Kuznetsova T.V., Baranov V.S.
 DNA methylation is one of the main mechanisms of epigenetic inheritance in eukaryotes. In this review we looked through the ways of 5-methylcytosin origin, it's distribution in genome, the mechanism of gene repression via hypermetilation, the role of metylation in genomic imprinting and in X-chromosome inactivation, in embryogenesis of mammals, in the processes of oncogenesis and in etiology of some common human inherited diseases
Ecological genetics. 2004;2(1):27-37
The analysis of association between Collal, VDR and CALCR genes and development of osteoporosis
Moskalenko M.V., Aseev M.V., Kotova S.A., Baranov V.S.
The allele rates of VDR, Collal and CALCR genes in 174 non-related individuals Northwest Russian population and in 70 patients with severe osteoporosis (SO) were investigated by PCR-RFLP method. The frequency of functionally abnormal allele t of VDR gene in a group of SO patients was Sl,4±5,9%, and it was significantly higher (p<0,001) than this one in population (32,6±4,9%). Analysis of Collal gene proved significant preponderance (p<0,0001) of functionally abnormal allele s in SO patients (50,0±5,9%) compared to its average frequency in population (17,5±4,9%). No significant differences (p>0,05) between frequencies of functionally abnormal T allele of CALCR gene in SO (84,4±4,9%) patients and its average frequency in population were recorded (73,8±3,9%). Thus, according to our data clear-cut association between functionally abnormal alleles of VDR and Collal genes and osteoporosis   
Ecological genetics. 2004;2(1):38-43
Reproductive characteristics of mouse males are influenced by the mouse female pheromone 2,5-dimethylpyrazine in the C57BL/6 strain
Daev E.V., Dukelskaya A.V.
The influence of the mouse female pheromone 2,5-dimethylpyrazine was studied on significant reproductive characteristics in C57BL/6 males. With this purpose the frequency of pheromonally induced sperm head abnormalities and dominant lethal frequency was analyzed. It is shown, that the level of different sperm head abnormalities increases significantly after exposure with the pheromones. Simultaneously with it the frequency of dominant lethals elevates significantly in the progeny of the treated males. Connection of the revealed effects with the destabilizing influence of the pheromone on the genome of dividing germ and somatic cells at laboratory mice is discussed
Ecological genetics. 2004;2(1):44-49

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