The analysis of association between Collal, VDR and CALCR genes and development of osteoporosis

Abstract


The allele rates of VDR, Collal and CALCR genes in 174 non-related individuals Northwest Russian population and in 70 patients with severe osteoporosis (SO) were investigated by PCR-RFLP method. The frequency of functionally abnormal allele t of VDR gene in a group of SO patients was Sl,4±5,9%, and it was significantly higher (p<0,001) than this one in population (32,6±4,9%). Analysis of Collal gene proved significant preponderance (p<0,0001) of functionally abnormal allele s in SO patients (50,0±5,9%) compared to its average frequency in population (17,5±4,9%). No significant differences (p>0,05) between frequencies of functionally abnormal T allele of CALCR gene in SO (84,4±4,9%) patients and its average frequency in population were recorded (73,8±3,9%). Thus, according to our data clear-cut association between functionally abnormal alleles of VDR and Collal genes and osteoporosis   

Mikhail V Moskalenko

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: mvmos@mail.ru

Mikhail V Aseev

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: micas@mail.ru

Svetlana A Kotova

Centre of Forensic Expertise and Criminalistics, Minsk, Republic of Belarus

Email: expertiza@telegraf.by

Vladislav S Baranov

D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology , Saint-Petersburg, RF

Email: baranov@vb2475.spb.edu

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Copyright (c) 2004 Moskalenko M.V., Aseev M.V., Kotova S.A., Baranov V.S.

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